Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 (original) (raw)

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Acknowledgements

We thank the family of individual EUFA1341 for contributing to this study, M. Makiya and C. de Leon Lucero for help in the collection of clinical data and J. Steltenpool and A. Oostra for expert technical assistance. The members of the Livingston laboratory are grateful to A. D'Andrea and his colleagues at the Dana Farber Cancer Institute for a number of useful discussions and for Fanconi anemia-related reagents. This study was financially supported by the Netherlands Organization for Health Research and Development (J.P.d.W. and N.A.); by grants, including a breast cancer SPORE, from the National Cancer Institute (D.M.L.); by the Breast Cancer Program of US Army Medical Research and Materiel Command (B.X.); by the Intramural Research Program of the National Institute on Aging, US National Institutes of Health (W.W.) and by the Fanconi Anemia Research Fund (H.J.)

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Author notes

  1. Bing Xia and Josephine C Dorsman: These authors contributed equally to this work.

Authors and Affiliations

  1. Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, 02115, Massachusetts, USA
    Bing Xia, Qing Sheng & David M Livingston
  2. Department of Clinical Genetics, VU Medical Center, Van der Boechorststraat 7, Amsterdam, The Netherlands, 1081 BT
    Josephine C Dorsman, Najim Ameziane, Yne de Vries, Martin A Rooimans, Gerard Pals, Hans Joenje & Johan P de Winter
  3. MRC-Holland BV, Hudsonstraat 68, Amsterdam, 1057, SN, The Netherlands
    Abdellatif Errami
  4. Bone Marrow Transplant Unit, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Eliane Gluckman
  5. Departamento de Pediatria, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    Julian Llera
  6. Laboratory of Genetics, National Institute on Aging, US National Institutes of Health, 333 Cassell Drive, Baltimore, 21224, Maryland, USA
    Weidong Wang

Authors

  1. Bing Xia
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  2. Josephine C Dorsman
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  3. Najim Ameziane
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  4. Yne de Vries
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  5. Martin A Rooimans
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  6. Qing Sheng
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  7. Gerard Pals
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  8. Abdellatif Errami
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  9. Eliane Gluckman
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  10. Julian Llera
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  11. Weidong Wang
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  12. David M Livingston
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  13. Hans Joenje
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  14. Johan P de Winter
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Corresponding authors

Correspondence toDavid M Livingston or Johan P de Winter.

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Competing interests

D.M.L is a scientific consultant to and recipient of a research grant from Novartis AG. A.E. is an employee of MRC-Holland BV.

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Xia, B., Dorsman, J., Ameziane, N. et al. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.Nat Genet 39, 159–161 (2007). https://doi.org/10.1038/ng1942

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