FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity (original) (raw)

References

  1. Sebat, J. et al. Science 305, 525–528 (2004).
    Article CAS Google Scholar
  2. Iafrate, A.J. et al. Nat. Genet. 36, 949–951 (2004).
    Article CAS Google Scholar
  3. Tuzun, E. et al. Nat. Genet. 37, 727–732 (2005).
    Article CAS Google Scholar
  4. Redon, R. et al. Nature 444, 444–454 (2006).
    Article CAS Google Scholar
  5. Stankiewicz, P. et al. Trends Genet. 18, 74–82 (2002).
    Article CAS Google Scholar
  6. Lupski, J.R. Nat. Genet. 38, 974–976 (2006).
    Article CAS Google Scholar
  7. Aitman, T.J. et al. Nature 439, 851–855 (2006).
    Article CAS Google Scholar
  8. Salmon, J.E. et al. Arthritis Rheum. 44, 739–750 (2001).
    Article CAS Google Scholar
  9. Takai, T. J. Clin. Immunol. 25, 1–18 (2005).
    Article CAS Google Scholar
  10. Nimmerjahn, F. et al. Immunity 24, 19–28 (2006).
    Article CAS Google Scholar
  11. de Haas, M. et al. Blood 86, 2403–2413 (1995).
    CAS PubMed Google Scholar
  12. Clark, M.R. et al. J. Clin. Invest. 86, 341–346 (1990).
    Article CAS Google Scholar
  13. Coxon, A. et al. Immunity 14, 693–704 (2001).
    Article CAS Google Scholar
  14. Harper, L. et al. J. Pathol. 190, 349–359 (2000).
    Article CAS Google Scholar
  15. Gonzalez, E. et al. Science 307, 1434–1440 (2005).
    Article CAS Google Scholar

Download references

Acknowledgements

We thank C. Neuwirth and Y. Tan (Clinical Sciences Centre); A. Wong (Imperial College); J. Cedric and M. Delpech (INSERM U567); M. Marre (INSERM U695) and B. Balkau (INSERM U780-IFR69) for their role in collecting patients and controls. We thank A. Tsalenko, A. Scheffer, N. Sampas, P. Tsang and L. Bruhn from Agilent Laboratories for contributions to the array comparative genomic hybridization results. We acknowledge intramural funding from the Clinical Sciences Centre (to T.J.A.) and support from the Wellcome Trust Cardiovascular Functional Genomics award (T.J.A.), from the FP6 EURATools (European Union contract number LSHG-CT-2005-019015) award (T.J.A.), from the UK MRC (T.J.A., H.T.C.) and from a Wellcome Trust Senior Fellowship (T.J.V.). We acknowledge use of genotype data from the British 1958 Birth Cohort DNA collection, funded by the UK Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02.

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Author notes

  1. Manuela Fanciulli, Penny J Norsworthy and Enrico Petretto: These authors contributed equally to this work.

Authors and Affiliations

  1. Physiological Genomics and Medicine Group, UK Medical Research Council (MRC) Clinical Sciences Centre, Imperial College, London, W12 0NN, UK
    Manuela Fanciulli, Penny J Norsworthy, Enrico Petretto, Rong Dong & Timothy J Aitman
  2. Division of Immunity and Infection, Renal Immunobiology, Medical School, University of Birmingham, Birmingham, B15 277, UK
    Lorraine Harper & Lavanya Kamesh
  3. Division of Medical Sciences, Medical School, University of Birmingham, Birmingham, B15 277, UK
    Joanne M Heward & Stephen C L Gough
  4. Division of Medicine, Section of Genomic Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Adam de Smith, Alexandra I F Blakemore & Philippe Froguel
  5. Centre National de la Recherche Scientifique (CNRS), UMR 8090-Institute of Biology, Pasteur Institute, Lille, 59800, France
    Philippe Froguel
  6. Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Catherine J Owen & Simon H S Pearce
  7. Department of Internal Medicine, Reference Center for Vasculitis and Systemic Sclerosis, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Descartes University 27, rue du Faubourg Saint-Jacques, Paris Cedex 14, 75679, France
    Luis Teixeira & Loic Guillevin
  8. Section of Molecular Genetics and Rheumatology, Imperial College London, London, W12 0NN, UK
    Deborah S Cunninghame Graham, Timothy J Vyse & Timothy J Aitman
  9. Renal Medicine, Imperial College London, London, W12 0NN, UK
    Charles D Pusey
  10. Department of Histopathology, Imperial College London, London, W12 0NN, UK
    H Terence Cook

Authors

  1. Manuela Fanciulli
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  2. Penny J Norsworthy
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  3. Enrico Petretto
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  4. Rong Dong
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  5. Lorraine Harper
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  6. Lavanya Kamesh
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  7. Joanne M Heward
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  8. Stephen C L Gough
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  9. Adam de Smith
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  10. Alexandra I F Blakemore
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  11. Philippe Froguel
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  12. Catherine J Owen
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  13. Simon H S Pearce
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  14. Luis Teixeira
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  15. Loic Guillevin
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  16. Deborah S Cunninghame Graham
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  17. Charles D Pusey
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  18. H Terence Cook
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  19. Timothy J Vyse
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  20. Timothy J Aitman
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Contributions

M.F., E.P., H.T.C., T.J.V. and T.J.A. designed the study. M.F., P.J.N. and R.D. performed PCR-based experiments. A.d.S., A.I.F.B. and P.F. performed oligonucleotide array comparative genomic hybridization analysis. M.F. and E.P. performed statistical and data analysis. L.H., L.K., J.M.H., S.C.L.G., P.F., C.J.O., S.H.S.P., L.T., L.G., D.S.G.G., C.D.P. and T.J.V. provided material and contributed to the collection of the case-control studies. The manuscript was written by M.F., E.P., H.T.C., T.J.V. and T.J.A.

Corresponding author

Correspondence toTimothy J Aitman.

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The authors declare no competing financial interests.

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Fanciulli, M., Norsworthy, P., Petretto, E. et al. FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.Nat Genet 39, 721–723 (2007). https://doi.org/10.1038/ng2046

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