Common variants in WFS1 confer risk of type 2 diabetes (original) (raw)

References

1. Gloyn, A.L. et al. Diabetes 52, 568–572 (2003).
   Article CAS Google Scholar
2. Nielsen, E.M. et al. Diabetes 52, 573–577 (2003).
   Article CAS Google Scholar
3. Silander, K. et al. Diabetes 53, 1141–1149 (2004).
   Article CAS Google Scholar
4. Love-Gregory, L.D. et al. Diabetes 53, 1134–1140 (2004).
   Article CAS Google Scholar
5. Grant, S.F. et al. Nat. Genet. 38, 320–323 (2006).
   Article CAS Google Scholar
6. Minton, J.A. et al. Diabetes 51, 1287–1290 (2002).
   Article CAS Google Scholar
7. Inoue, H. et al. Nat. Genet. 20, 143–148 (1998).
   Article CAS Google Scholar
8. Strom, T.M. et al. Hum. Mol. Genet. 7, 2021–2028 (1998).
   Article CAS Google Scholar
9. Riggs, A.C. et al. Diabetologia 48, 2313–2321 (2005).
   Article CAS Google Scholar
10. Ishihara, H. et al. Hum. Mol. Genet. 13, 1159–1170 (2004).
    Article CAS Google Scholar
11. Karasik, A. et al. Diabetes Care 12, 135–138 (1989).
    Article CAS Google Scholar
12. Yamada, T. et al. Hum. Mol. Genet. 15, 1600–1609 (2006).
    Article CAS Google Scholar
13. Ozcan, U. et al. Science. 313, 1137–1140 (2006).
    Article Google Scholar
14. Altshuler, D. et al. Nat. Genet. 26, 76–80 (2000).
    Article CAS Google Scholar

Download references

Acknowledgements

We thank all study participants. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the UK Medical Research Council (MRC) grant G0000934 and the Wellcome Trust grant 068545/Z/02. The Ashkenazi population was collected by the Israeli Diabetes Research Group, funded by the Russell Berrie Foundation, D-Cure, Diabetes Care in Israel, Israel Ministry of Health and an unrestricted research grant from Novo-Nordisk. The Wellcome Trust and Diabetes UK funded the Warren 2 study. The work on the Cambridgeshire case-control, Ely, ADDITION and EPIC-Norfolk studies was funded by support from the Wellcome Trust and MRC. We are grateful to S. Griffin, MRC Epidemiology Unit for assistance with the ADDITION study and to S. O'Rahilly and M. Sampson for their contribution to the Warren 2 study. The UK type 2 diabetes case/control collection (Go-DARTS2) was funded by the Wellcome Trust. C.N.A.P. and A.D.M. are supported by the Scottish Executive Chief Scientist's Office as part of the Generation Scotland initiative. Illumina genotyping was done by P. Deloukas's laboratory at the Wellcome Trust Sanger Institute. I. Blech. and K.A.F. are funded by the Wellcome Trust. I.B. acknowledges support from EU FP6 funding (contract number LSHM-CT-2003-503041). A.T.H. is a Wellcome Trust Research Leave Fellow. M.N.W. is a Vandervell Foundation Research Fellow. S.L.D. is funded by the British Heart Foundation. None of the sponsors or funders had any role in the design and conduct of the study, in the collection, analysis and interpretation of the data or in the preparation, review or approval of the manuscript.

Author information

Author notes

1. Manjinder S Sandhu and Michael N Weedon: These authors contributed equally to this work.

Authors and Affiliations

1. UK Medical Research Council (MRC) Epidemiology Unit, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK
   Manjinder S Sandhu & Nicholas J Wareham
2. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK
   Manjinder S Sandhu & Sally L Debenham
3. Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, EX1 2LU, UK
   Michael N Weedon, Hana Lango, Timothy M Frayling & Andrew T Hattersley
4. Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
   Katherine A Fawcett, Allan Daly & Inês Barroso
5. Washington University School of Medicine, St. Louis, 63110, Missouri, USA
   Jon Wasson, Rosalind J Neumann, Richard Sherva & M Alan Permutt
6. Endocrine and Metabolism Service, The Hadassah Hebrew University Medical Center, Jerusalem, 91120, Israel
   Ilana Blech & Benjamin Glaser
7. Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK
   Paul D Pharoah
8. Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Dundee, DD1 9SY, UK
   Colin N A Palmer, Charlotte Kimber & Roger Tavendale
9. Division of Medicine and Therapeutics, Diabetes Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
   Andrew D Morris
10. Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, OX3 7LJ, UK
    Mark I McCarthy
11. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Mark I McCarthy
12. Diabetes Research Group, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Mark Walker
13. Centre for Diabetes and Metabolic Medicine, Barts and the London, Queen Mary's School of Medicine and Dentistry, University of London, London, E1 1BB, UK
    Graham Hitman

Authors

1. Manjinder S Sandhu
   You can also search for this author inPubMed Google Scholar
2. Michael N Weedon
   You can also search for this author inPubMed Google Scholar
3. Katherine A Fawcett
   You can also search for this author inPubMed Google Scholar
4. Jon Wasson
   You can also search for this author inPubMed Google Scholar
5. Sally L Debenham
   You can also search for this author inPubMed Google Scholar
6. Allan Daly
   You can also search for this author inPubMed Google Scholar
7. Hana Lango
   You can also search for this author inPubMed Google Scholar
8. Timothy M Frayling
   You can also search for this author inPubMed Google Scholar
9. Rosalind J Neumann
   You can also search for this author inPubMed Google Scholar
10. Richard Sherva
    You can also search for this author inPubMed Google Scholar
11. Ilana Blech
    You can also search for this author inPubMed Google Scholar
12. Paul D Pharoah
    You can also search for this author inPubMed Google Scholar
13. Colin N A Palmer
    You can also search for this author inPubMed Google Scholar
14. Charlotte Kimber
    You can also search for this author inPubMed Google Scholar
15. Roger Tavendale
    You can also search for this author inPubMed Google Scholar
16. Andrew D Morris
    You can also search for this author inPubMed Google Scholar
17. Mark I McCarthy
    You can also search for this author inPubMed Google Scholar
18. Mark Walker
    You can also search for this author inPubMed Google Scholar
19. Graham Hitman
    You can also search for this author inPubMed Google Scholar
20. Benjamin Glaser
    You can also search for this author inPubMed Google Scholar
21. M Alan Permutt
    You can also search for this author inPubMed Google Scholar
22. Andrew T Hattersley
    You can also search for this author inPubMed Google Scholar
23. Nicholas J Wareham
    You can also search for this author inPubMed Google Scholar
24. Inês Barroso
    You can also search for this author inPubMed Google Scholar

Contributions

I. Barroso, A.T.H., M.A.P., N.J.W. and M.S.S. designed this study; M.S.S. did the statistical analysis, supported by I. Barroso, A.D., S.L.D., K.A.F., H.L., R.J.N., P.D.P., R.S. and M.N.W. M.S.S. wrote the manuscript with I. Barroso, S.L.D. and K.A.F.; A.D. conducted the bioinformatic analysis; I. Blech., S.L.D., K.A.F. and C.K. arrayed and genotyped the replication studies; B.G., A.T.H., G.H., C.K., A.D.M., M.I.M., C.N.A.P., M.W., R.T., J.W. and N.J.W. provided study samples and all authors contributed to data interpretation and commented on the final manuscript.

Corresponding authors

Correspondence toManjinder S Sandhu or Inês Barroso.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

About this article

Cite this article

Sandhu, M., Weedon, M., Fawcett, K. et al. Common variants in WFS1 confer risk of type 2 diabetes.Nat Genet 39, 951–953 (2007). https://doi.org/10.1038/ng2067

Download citation

• Received: 07 February 2007
• Accepted: 17 May 2007
• Published: 01 July 2007
• Issue Date: August 2007
• DOI: https://doi.org/10.1038/ng2067