Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry (original) (raw)

• Mizushima, N., Levine, B., Cuervo, A.M. & Klionsky, D.J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069–1075 (2008).
  CAS PubMed PubMed Central Google Scholar
• Reggiori, F. & Klionsky, D.J. Autophagosomes: biogenesis from scratch? Curr. Opin. Cell Biol. 17, 415–422 (2005).
  Article CAS PubMed Google Scholar
• Hussey, S., Travassos, L.H. & Jones, N.L. Autophagy as an emerging dimension to adaptive and innate immunity. Semin. Immunol. 21, 233–241 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Marx, J. Autophagy: is it cancer's friend or foe? Science 312, 1160–1161 (2006).
  Article CAS PubMed Google Scholar
• Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885–889 (2006).
  Article CAS PubMed Google Scholar
• Nakagawa, I. et al. Autophagy defends cells against invading group A Streptococcus. Science 306, 1037–1040 (2004).
  Article CAS PubMed Google Scholar
• Birmingham, C.L. et al. Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy 3, 442–451 (2007).
  Article CAS PubMed Google Scholar
• Ogawa, M. et al. Escape of intracellular Shigella from autophagy. Science 307, 727–731 (2005).
  Article CAS PubMed Google Scholar
• Gutierrez, M.G. et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119, 753–766 (2004).
  Article CAS PubMed Google Scholar
• Birmingham, C.L. & Brumell, J.H. Autophagy recognizes intracellular Salmonella enterica serovar Typhimurium in damaged vacuoles. Autophagy 2, 156–158 (2006).
  Article CAS PubMed Google Scholar
• Carneiro, L., Magalhaes, J., Tattoli, I., Philpott, D. & Travassos, L. Nod-like proteins in inflammation and disease. J. Pathol. 214, 136–148 (2008).
  Article CAS PubMed Google Scholar
• Martinon, F. & Tschopp, J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26, 447–454 (2005).
  Article CAS PubMed Google Scholar
• Meylan, E., Tschopp, J. & Karin, M. Intracellular pattern recognition receptors in the host response. Nature 442, 39–44 (2006).
  Article CAS PubMed Google Scholar
• Chamaillard, M. et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 4, 702–707 (2003).
  Article CAS PubMed Google Scholar
• Girardin, S.E. et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300, 1584–1587 (2003).
  Article CAS PubMed Google Scholar
• Girardin, S.E. et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869–8872 (2003).
  Article CAS PubMed Google Scholar
• Girardin, S.E. et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J. Biol. Chem. 278, 41702–41708 (2003).
  Article CAS PubMed Google Scholar
• Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278, 5509–5512 (2003).
  Article CAS PubMed Google Scholar
• Inohara, N. et al. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem. 275, 27823–27831 (2000).
  CAS PubMed Google Scholar
• Abbott, D.W., Wilkins, A., Asara, J.M. & Cantley, L.C. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14, 2217–2227 (2004).
  Article CAS PubMed Google Scholar
• Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599–603 (2001).
  Article CAS PubMed Google Scholar
• Rioux, J.D. et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 39, 596–604 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207–211 (2007).
  Article CAS PubMed Google Scholar
• Fritz, J.H. et al. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 26, 445–459 (2007).
  Article CAS PubMed Google Scholar
• Magalhaes, J.G. et al. Nod2-dependent Th2 polarization of antigen-specific immunity. J. Immunol. 181, 7925–7935 (2008).
  Article CAS PubMed Google Scholar
• Delgado, M.A., Elmaoued, R.A., Davis, A.S., Kyei, G. & Deretic, V. Toll-like receptors control autophagy. EMBO J. 27, 1110–1121 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Klionsky, D.J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151–175 (2008).
  Article CAS PubMed Google Scholar
• Mizushima, N., Ohsumi, Y. & Yoshimori, T. Autophagosome formation in mammalian cells. Cell Struct. Funct. 27, 421–429 (2002).
  Article PubMed Google Scholar
• Magalhaes, J.G. et al. Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep. 6, 1201–1207 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Opitz, B. et al. Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J. Immunol. 176, 484–490 (2006).
  Article CAS PubMed Google Scholar
• Travassos, L.H. et al. Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J. Biol. Chem. 280, 36714–36718 (2005).
  Article CAS PubMed Google Scholar
• Viala, J. et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat. Immunol. 5, 1166–1174 (2004).
  Article CAS PubMed Google Scholar
• Carneiro, L.A. et al. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 5, 123–136 (2009).
  Article CAS PubMed Google Scholar
• Opitz, B. et al. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ. Res. 96, 319–326 (2005).
  Article CAS PubMed Google Scholar
• Kim, S., La Motte-Mohs, R.N., Rudolph, D., Zuniga-Pflucker, J.C. & Mak, T.W. The role of nuclear factor-κB essential modulator (NEMO) in B cell development and survival. Proc. Natl. Acad. Sci. USA 100, 1203–1208 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Barnich, N., Aguirre, J.E., Reinecker, H.C., Xavier, R. & Podolsky, D.K. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-κB activation in muramyl dipeptide recognition. J. Cell Biol. 170, 21–26 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Lecine, P. et al. The NOD2-RICK complex signals from the plasma membrane. J. Biol. Chem. 282, 15197–15207 (2007).
  Article CAS PubMed Google Scholar
• Till, A. et al. A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion. J. Cell Sci. 121, 487–495 (2008).
  Article CAS PubMed Google Scholar
• Fujita, N. et al. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol. Biol. Cell 19, 2092–2100 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Kuballa, P., Huett, A., Rioux, J.D., Daly, M.J. & Xavier, R.J. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE 3, e3391 (2008).
  Article PubMed PubMed Central Google Scholar
• Xu, Y. et al. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27, 135–144 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Kaneko, T. et al. PGRP-LC and PGRP-LE have essential yet distinct functions in the Drosophila immune response to monomeric DAP-type peptidoglycan. Nat. Immunol. 7, 715–723 (2006).
  Article CAS PubMed Google Scholar
• Zaidman-Remy, A. et al. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity 24, 463–473 (2006).
  Article CAS PubMed Google Scholar
• Yano, T. et al. Autophagic control of listeria through intracellular innate immune recognition in Drosophila. Nat. Immunol. 9, 908–916 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Hofius, D. et al. Autophagic components contribute to hypersensitive cell death in Arabidopsis. Cell 137, 773–783 (2009).
  Article CAS PubMed Google Scholar
• Allaoui, A., Mounier, J., Prevost, M.C., Sansonetti, P.J. & Parsot, C. icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread. Mol. Microbiol. 6, 1605–1616 (1992).
  Article CAS PubMed Google Scholar
• Jounai, N. et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc. Natl. Acad. Sci. USA 104, 14050–14055 (2007).
  Article CAS PubMed PubMed Central Google Scholar