Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 (original) (raw)

• Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446–458 (2005).
  Article CAS Google Scholar
• Iwami, K.I. et al. Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J. Immunol. 165, 6682–6686 (2000).
  Article CAS Google Scholar
• Janssens, S., Burns, K., Vercammen, E., Tschopp, J. & Beyaert, R. MyD88S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression. FEBS Lett. 548, 103–107 (2003).
  Article CAS Google Scholar
• Kobayashi, K. et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191–202 (2002).
  Article CAS Google Scholar
• Palsson-McDermott, E.M. et al. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat. Immunol. 10, 579–586 (2009).
  Article CAS Google Scholar
• Sun, S.C., Ganchi, P.A., Ballard, D.W. & Greene, W.C. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259, 1912–1915 (1993).
  Article CAS Google Scholar
• Murray, P.J. STAT3-mediated anti-inflammatory signalling. Biochem. Soc. Trans. 34, 1028–1031 (2006).
  Article CAS Google Scholar
• Taganov, K.D., Boldin, M.P., Chang, K.J. & Baltimore, D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103, 12481–12486 (2006).
  Article CAS Google Scholar
• Shibahara, K. et al. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene 166, 297–301 (1995).
  Article CAS Google Scholar
• Yang, H.S., Knies, J.L., Stark, C. & Colburn, N.H. Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene 22, 3712–3720 (2003).
  Article CAS Google Scholar
• Onishi, Y., Hashimoto, S. & Kizaki, H. Cloning of the TIS gene suppressed by topoisomerase inhibitors. Gene 215, 453–459 (1998).
  Article CAS Google Scholar
• Yang, H.S. et al. A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-κB or ODC transactivation. Oncogene 20, 669–676 (2001).
  Article CAS Google Scholar
• Yang, H.S. et al. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol. Cell. Biol. 23, 26–37 (2003).
  Article Google Scholar
• Loh, P.G. et al. Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J. 28, 274–285 (2009).
  Article CAS Google Scholar
• Hilliard, A. et al. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J. Immunol. 177, 8095–8102 (2006).
  Article CAS Google Scholar
• Dorrello, N.V. et al. S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314, 467–471 (2006).
  Article CAS Google Scholar
• Schmid, T. et al. Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res. 68, 1254–1260 (2008).
  Article CAS Google Scholar
• Asangani, I.A. et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27, 2128–2136 (2008).
  Article CAS Google Scholar
• Frankel, L.B. et al. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J. Biol. Chem. 283, 1026–1033 (2008).
  Article CAS Google Scholar
• Lu, Z. et al. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27, 4373–4379 (2008).
  Article CAS Google Scholar
• Cmarik, J.L. et al. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc. Natl. Acad. Sci. USA 96, 14037–14042 (1999).
  Article CAS Google Scholar
• Rousseau, D., Kaspar, R., Rosenwald, I., Gehrke, L. & Sonenberg, N. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc. Natl. Acad. Sci. USA 93, 1065–1070 (1996).
  Article CAS Google Scholar
• Graff, J.R. et al. Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E. Biochem. Biophys. Res. Commun. 240, 15–20 (1997).
  Article CAS Google Scholar
• Talotta, F. et al. An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. Oncogene 28, 73–84 (2009).
  Article CAS Google Scholar
• Fujita, S. et al. miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 378, 492–504 (2008).
  Article CAS Google Scholar
• Loffler, D. et al. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood 110, 1330–1333 (2007).
  Article Google Scholar
• Calin, G.A. & Croce, C.M. MicroRNA signatures in human cancers. Nat. Rev. Cancer 6, 857–866 (2006).
  Article CAS Google Scholar
• Cho, W.C. OncomiRs: the discovery and progress of microRNAs in cancers. Mol. Cancer 6, 60 (2007).
  Article Google Scholar
• Moschos, S.A. et al. Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics 8, 240 (2007).
  Article Google Scholar
• Lu, T.X., Munitz, A. & Rothenberg, M.E. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J. Immunol. 182, 4994–5002 (2009).
  Article CAS Google Scholar
• Iliopoulos, D., Malizos, K.N., Oikonomou, P. & Tsezou, A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS ONE 3, e3740 (2008).
  Article Google Scholar
• Sonkoly, E. et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS ONE 2, e610 (2007).
  Article Google Scholar
• Wu, F. et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2α. Gastroenterology 135, 1624–1635 (2008).
  Article CAS Google Scholar
• Zhang, Z. et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab. Invest. 88, 1358–1366 (2008).
  Article CAS Google Scholar
• Ji, R. et al. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ. Res. 100, 1579–1588 (2007).
  Article CAS Google Scholar
• Cheng, Y. et al. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am. J. Pathol. 170, 1831–1840 (2007).
  Article CAS Google Scholar
• O'Connell, R.M., Taganov, K.D., Boldin, M.P., Cheng, G. & Baltimore, D. MicroRNA-155 is induced during the macrophage inflammatory response. Proc. Natl. Acad. Sci. USA 104, 1604–1609 (2007).
  Article CAS Google Scholar
• Ceppi, M. et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc. Natl. Acad. Sci. USA 106, 2735–2740 (2009).
  Article CAS Google Scholar
• Thai, T.H. et al. Regulation of the germinal center response by microRNA-155. Science 316, 604–608 (2007).
  Article CAS Google Scholar
• Rodriguez, A. et al. Requirement of bic/microRNA-155 for normal immune function. Science 316, 608–611 (2007).
  Article CAS Google Scholar
• Bazzoni, F. et al. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc. Natl. Acad. Sci. USA 106, 5282–5287 (2009).
  Article CAS Google Scholar
• Liu, G. et al. miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc. Natl. Acad. Sci. USA (2009).
• Alsaleh, G. et al. Bruton's tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes. J. Immunol. 182, 5088–5097 (2009).
  Article CAS Google Scholar
• Chen, X.M., Splinter, P.L., O'Hara, S.P. & LaRusso, N.F. A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J. Biol. Chem. 282, 28929–28938 (2007).
  Article CAS Google Scholar
• Tili, E. et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock. J. Immunol. 179, 5082–5089 (2007).
  Article CAS Google Scholar
• Naora, H., Altin, J.G. & Young, I.G. TCR-dependent and -independent signaling mechanisms differentially regulate lymphokine gene expression in the murine T helper clone D10.G4.1. J. Immunol. 152, 5691–5702 (1994).
  CAS PubMed Google Scholar
• Nemeth, Z.H. et al. Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J. Immunol. 175, 8260–8270 (2005).
  Article CAS Google Scholar
• Sharma, A. et al. Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc. Natl. Acad. Sci. USA 106, 5761–5766 (2009).
  Article CAS Google Scholar
• van Duin, D., Medzhitov, R. & Shaw, A.C. Triggering TLR signaling in vaccination. Trends Immunol. 27, 49–55 (2006).
  Article CAS Google Scholar
• Cook, D.N., Pisetsky, D.S. & Schwartz, D.A. Toll-like receptors in the pathogenesis of human disease. Nat. Immunol. 5, 975–979 (2004).
  Article CAS Google Scholar
• Bowie, A. et al. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 97, 10162–10167 (2000).
  Article CAS Google Scholar