Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells (original) (raw)
Moore, K.W., de Waal Malefyt, R., Coffman, R.L. & O'Garra, A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol.19, 683–765 (2001). ArticleCASPubMed Google Scholar
Gazzinelli, R.T. et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J. Immunol.157, 798–805 (1996). CASPubMed Google Scholar
O'Garra, A. & Vieira, P. TH1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol.7, 425–428 (2007). ArticleCASPubMed Google Scholar
Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell75, 263–274 (1993). ArticleCASPubMed Google Scholar
Franke, A. et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat. Genet.40, 1319–1323 (2008). ArticleCASPubMed Google Scholar
Hunter, C.A. et al. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J. Immunol.158, 3311–3316 (1997). CASPubMed Google Scholar
Groux, H. et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature389, 737–742 (1997). ArticleCASPubMed Google Scholar
Murphy, K.M. et al. Signaling and transcription in T helper development. Annu. Rev. Immunol.18, 451–494 (2000). ArticleCASPubMed Google Scholar
Sakaguchi, S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol.6, 345–352 (2005). ArticleCASPubMed Google Scholar
McGeachy, M.J. et al. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology. Nat. Immunol.8, 1390–1397 (2007). ArticleCASPubMed Google Scholar
Del Prete, G. et al. Human IL-10 is produced by both type 1 helper (TH1) and type 2 helper (TH2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol.150, 353–360 (1993). CASPubMed Google Scholar
Assenmacher, M., Schmitz, J. & Radbruch, A. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur. J. Immunol.24, 1097–1101 (1994). ArticleCASPubMed Google Scholar
Windhagen, A., Anderson, D.E., Carrizosa, A., Williams, R.E. & Hafler, D.A. IL-12 induces human T cells secreting IL-10 with IFN-γ. J. Immunol.157, 1127–1131 (1996). CASPubMed Google Scholar
Gerosa, F. et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med.183, 2559–2569 (1996). ArticleCASPubMed Google Scholar
Gerosa, F. et al. CD4+ T cell clones producing both interferon-γ and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients. Clin. Immunol.92, 224–234 (1999). ArticleCASPubMed Google Scholar
Anderson, C.F., Oukka, M., Kuchroo, V.J. & Sacks, D. CD4+CD25−Foxp3− TH1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med.204, 285–297 (2007). ArticleCASPubMedPubMed Central Google Scholar
Jankovic, D. et al. Conventional T-bet+Foxp3− TH1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med.204, 273–283 (2007). ArticleCASPubMedPubMed Central Google Scholar
Gabrysova, L. et al. Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting TH1 cells. J. Exp. Med.206, 1755–1767 (2009). ArticleCASPubMedPubMed Central Google Scholar
Kemper, C. et al. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature421, 388–392 (2003). ArticleCASPubMed Google Scholar
Kemper, C. & Atkinson, J.P. T-cell regulation: with complements from innate immunity. Nat. Rev. Immunol.7, 9–18 (2007). ArticleCASPubMed Google Scholar
Caudy, A.A., Reddy, S.T., Chatila, T., Atkinson, J.P. & Verbsky, J.W. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J. Allergy Clin. Immunol.119, 482–487 (2007). ArticleCASPubMed Google Scholar
Seya, T., Turner, J.R. & Atkinson, J.P. Purification and characterization of a membrane protein (gp45–70) that is a cofactor for cleavage of C3b and C4b. J. Exp. Med.163, 837–855 (1986). ArticleCASPubMed Google Scholar
Astier, A., Trescol-Biemont, M.C., Azocar, O., Lamouille, B. & Rabourdin-Combe, C. Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. J. Immunol.164, 6091–6095 (2000). ArticleCASPubMed Google Scholar
Zaffran, Y. et al. CD46/CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-regulated kinase mitogen-activated protein kinase. J. Immunol.167, 6780–6785 (2001). ArticleCASPubMed Google Scholar
Liszewski, M.K., Post, T.W. & Atkinson, J.P. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol.9, 431–455 (1991). ArticleCASPubMed Google Scholar
Wang, G., Liszewski, M.K., Chan, A.C. & Atkinson, J.P. Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J. Immunol.164, 1839–1846 (2000). ArticleCASPubMed Google Scholar
Astier, A.L. et al. RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. J. Immunol.184, 685–693 (2010). ArticleCASPubMed Google Scholar
Strainic, M.G. et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity28, 425–435 (2008). ArticleCASPubMedPubMed Central Google Scholar
Price, J.D. et al. Induction of a regulatory phenotype in human CD4+ T cells by streptococcal M protein. J. Immunol.175, 677–684 (2005). ArticleCASPubMed Google Scholar
Sanchez, A., Feito, M.J. & Rojo, J.M. CD46-mediated costimulation induces a TH1-biased response and enhances early TCR/CD3 signaling in human CD4+ T lymphocytes. Eur. J. Immunol.34, 2439–2448 (2004). ArticleCASPubMed Google Scholar
Pennington, D.J. et al. Early events in the thymus affect the balance of effector and regulatory T cells. Nature444, 1073–1077 (2006). ArticleCASPubMed Google Scholar
Glimcher, L.H. & Murphy, K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev.14, 1693–1711 (2000). CASPubMed Google Scholar
Stockinger, B. & Veldhoen, M. Differentiation and function of TH17 T cells. Curr. Opin. Immunol.19, 281–286 (2007). ArticleCASPubMed Google Scholar
Saraiva, M. et al. Interleukin-10 production by TH1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity31, 209–219 (2009). ArticleCASPubMedPubMed Central Google Scholar
Powell, J.D., Lerner, C.G., Ewoldt, G.R. & Schwartz, R.H. The −180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy. J. Immunol.163, 6631–6639 (1999). CASPubMed Google Scholar
Li, Y. et al. SPAK kinase is a substrate and target of PKCθ in T-cell receptor-induced AP-1 activation pathway. EMBO J.23, 1112–1122 (2004). ArticleCASPubMedPubMed Central Google Scholar
Delpire, E. & Gagnon, K.B. SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem. J.409, 321–331 (2008). ArticleCASPubMed Google Scholar
Chen, J. & Liu, X.S. Development and function of IL-10 IFN-γ-secreting CD4+ T cells. J. Leukoc. Biol.86, 1305–1310 (2009). ArticleCASPubMed Google Scholar
Carroll, M.C. The complement system in regulation of adaptive immunity. Nat. Immunol.5, 981–986 (2004). ArticleCASPubMed Google Scholar
Morgan, B.P., Marchbank, K.J., Longhi, M.P., Harris, C.L. & Gallimore, A.M. Complement: central to innate immunity and bridging to adaptive responses. Immunol. Lett.97, 171–179 (2005). ArticleCASPubMed Google Scholar
Friec, G.L. & Kemper, C. Complement: coming full circle. Arch. Immunol. Ther. Exp. (Warsz.)57, 393–407 (2009). Article Google Scholar
Kerekes, K., Prechl, J., Bajtay, Z., Jozsi, M. & Erdei, A. A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells. Int. Immunol.10, 1923–1930 (1998). ArticleCASPubMed Google Scholar
Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. & Enk, A.H. Induction of interleukin 10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med.192, 1213–1222 (2000). ArticleCASPubMedPubMed Central Google Scholar
Astier, A.L., Meiffren, G., Freeman, S. & Hafler, D.A. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J. Clin. Invest.116, 3252–3257 (2006). ArticleCASPubMedPubMed Central Google Scholar
Meiler, F. et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J. Exp. Med.205, 2887–2898 (2008). ArticleCASPubMedPubMed Central Google Scholar
Rubtsov, Y.P. et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity28, 546–558 (2008). ArticleCASPubMed Google Scholar
White, J. et al. Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli. Protein Sci.13, 2406–2415 (2004). ArticleCASPubMedPubMed Central Google Scholar