Glycolytic reprogramming by TLRs in dendritic cells (original) (raw)

• News & Views
• Published: 19 March 2014

Nature Immunology volume 15, pages 314–315 (2014)Cite this article

• 6512 Accesses
• 45 Citations
• 2 Altmetric
• Metrics details

Subjects

The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

• Purchase on SpringerLink
• Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

• Log in
• Learn about institutional subscriptions
• Read our FAQs
• Contact customer support

Figure 1: Citrate and DC activation.

The alternative text for this image may have been generated using AI.

References

1. Krawczyk, C.M. et al. Blood 115, 4742–4749 (2010).
   Article CAS Google Scholar
2. Tannahill, G.M. et al. Nature 496, 238–242 (2013).
   Article CAS Google Scholar
3. Infantino, V. et al. Biochem. J. 438, 433–436 (2011).
   Article CAS Google Scholar
4. Everts, B. et al. Blood 120, 1422–1431 (2012).
   Article CAS Google Scholar
5. Everts, B. et al. Nat. Immunol. 15, 323–332 (2014).
   Article CAS Google Scholar
6. Hardie, D.G. & O'Neill, L.A.J. Nature 493, 346–355 (2013).
   Article Google Scholar
7. Ibrahim, J. et al. Gastroenterology 143, 1061–1072 (2012).
   Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

1. Luke A.J. O'Neill is with the Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.,
   Luke A J O'Neill

Corresponding author

Correspondence toLuke A J O'Neill.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

About this article

Cite this article

O'Neill, L. Glycolytic reprogramming by TLRs in dendritic cells.Nat Immunol 15, 314–315 (2014). https://doi.org/10.1038/ni.2852

Download citation

• Published: 19 March 2014
• Issue date: April 2014
• DOI: https://doi.org/10.1038/ni.2852

This article is cited by