Crohn's disease-associated Nod2 mutants reduce IL10 transcription (original) (raw)

Nature Immunology volume 10, pages 455–457 (2009)Cite this article

The 3020insC mutation in Nod2 is associated with Crohn's disease, but how it influences disease pathogenesis is unknown. A new study shows that the 3020insC mutant protein fails to activate a key transcription factor that drives interleukin 10 expression, resulting in reduced production of this anti-inflammatory cytokine.

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Figure 1: Reduced production of IL-10 in cells expressing Crohn's disease–associated mutations in Nod2.

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Authors and Affiliations

  1. Dana J. Philpott is in the Department of Immunology and Stephen E. Girardin is in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Toronto, Ontario, Canada. dana.philpott@utoronto.ca,
    Dana J Philpott & Stephen E Girardin

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  1. Dana J Philpott
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  2. Stephen E Girardin
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Philpott, D., Girardin, S. Crohn's disease-associated Nod2 mutants reduce IL10 transcription.Nat Immunol 10, 455–457 (2009). https://doi.org/10.1038/ni0509-455

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