Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein (original) (raw)

• Tsukada, S., Rawlings, D. J. & Witte, O. N. Role of Bruton's tyrosine kinase in immunodeficiency. Curr. Opin. Immunol. 6, 623–630 (1994).
  Article CAS Google Scholar
• Yamada, N. et al. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem. Biophys. Res. Commun. 192, 231–240 (1993).
  Article CAS Google Scholar
• Tsukada, S. et al. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72, 279–290 (1993).
  Article CAS Google Scholar
• de Weers, M., Mensink, R. G., Kraakman, M. E., Schuurman, R. K. & Hendriks, R. W. Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. Hum. Mol. Genet. 3, 161–166 (1994).
  Article CAS Google Scholar
• Bruton, C. Agammaglogulinemia. Pediatrics 9, 722–731 (1952).
  CAS PubMed Google Scholar
• Vetrie, D. et al. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361, 226–233 (1993).
  Article CAS Google Scholar
• Rawlings, D. J. et al. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 261, 358–361 (1993).
  Article CAS Google Scholar
• Thomas, J. D. et al. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 261, 355–358 (1993).
  Article CAS Google Scholar
• Uckun, F. M. et al. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science 273, 1096–1100 (1996).
  Article CAS Google Scholar
• Scharenberg, A. M. & Kinet, J. P. PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell 94, 5–8 (1998).
  Article CAS Google Scholar
• Bajpai, U. D., Zhang, K., Teutsch, M., Sen, R. & Wortis, H. H. Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation. J. Exp. Med. 191, 1735–1744 (2000).
  Article CAS Google Scholar
• Petro, J. B., Rahman, S. M., Ballard, D. W. & Khan, W. N. Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor κB in response to B cell receptor engagement. J. Exp. Med. 191, 1745–1754 (2000).
  Article CAS Google Scholar
• Yang, W. & Desiderio, S. BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc. Natl. Acad. Sci. USA 94, 604–609 (1997).
  Article CAS Google Scholar
• Novina, C. D. et al. Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. Mol. Cell. Biol. 19, 5014–5024 (1999).
  Article CAS Google Scholar
• Fruman, D. A., Satterthwaite, A. B. & Witte, O. N. Xid-like phenotypes: a B cell signalosome takes shape. Immunity 13, 1–3 (2000).
  Article CAS Google Scholar
• Hendriks, R. W. et al. Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J. 15, 4862–4872 (1996).
  Article CAS Google Scholar
• Kerner, J. D. et al. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3, 301–312 (1995).
  Article CAS Google Scholar
• Langhans-Rajasekaran, S. A., Wan, Y. & Huang, X. Y. Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits. Proc. Natl. Acad. Sci. USA 92, 8601–8605 (1995).
  Article CAS Google Scholar
• Jiang, Y. et al. The G protein G α12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature 395, 808–813 (1998).
  Article CAS Google Scholar
• Mao, J. et al. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13. EMBO J 17, 5638–5646 (1998).
  Article CAS Google Scholar
• Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805–816 (1993).
  Article CAS Google Scholar
• Vihinen, M., Nilsson, L. & Smith, C. I. Tec homology (TH) adjacent to the PH domain. FEBS Lett. 350, 263–265 (1994).
  Article CAS Google Scholar
• Schaeffer, E. M. et al. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284, 638–641. (1999).
  Article CAS Google Scholar
• Bolland, S., Pearse, R. N., Kurosaki, T. & Ravetch, J. V. SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity 8, 509–516 (1998).
  Article CAS Google Scholar
• Satterthwaite, A. B., Li, Z. & Witte, O. N. Btk function in B cell development and response. Semin. Immunol. 10, 309–316 (1998).
  Article CAS Google Scholar
• Andreotti, A. H., Bunnell, S. C., Feng, S., Berg, L. J. & Schreiber, S. L. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature 385, 93–97 (1997).
  Article CAS Google Scholar
• Morrogh, L. M., Hinshelwood, S., Costello, P., Cory, G. O. & Kinnon, C. The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. Eur. J. Immunol. 29, 2269–2279 (1999).
  Article CAS Google Scholar
• Park, H. et al. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4, 515–525 (1996).
  Article CAS Google Scholar
• Bence, K., Ma, W., Kozasa, T. & Huang, X. Y. Direct stimulation of Bruton's tyrosine kinase by G(q)-protein α-subunit. Nature 389, 296–299 (1997).
  Article CAS Google Scholar
• Fluckiger, A. C. et al. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J. 17, 1973–1985 (1998).
  Article CAS Google Scholar
• Wahl, M. I. et al. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc. Natl. Acad. Sci. USA 94, 11526–11533 (1997).
  Article CAS Google Scholar
• Rigley, K. P., Harnett, M. M., Phillips, R. J. & Klaus, G. G. Analysis of signaling via surface immunoglobulin receptors on B cells from CBA/N mice. Eur. J. Immunol. 19, 2081–2086 (1989).
  Article CAS Google Scholar
• Schaeffer, E. M. et al. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284, 638–641 (1999).
  Article CAS Google Scholar
• Rosen, F. S., Cooper, M. D. & Wedgwood, R. J. The primary immunodeficiencies. N. Engl. J. Med. 333, 431–440 (1995).
  Article CAS Google Scholar
• Vihinen, M. et al. BTKbase, mutation database for X-linked agammaglobulinemia (XLA). Nucleic Acids Res. 26, 242–247 (1998).
  Article CAS Google Scholar
• Bykowsky, M. J. et al. Discordant phenotype in siblings with X-linked agammaglobulinemia. Am. J. Hum. Genet. 58, 477–483 (1996).
  CAS PubMed PubMed Central Google Scholar
• Kornfeld, S. J. et al. A novel mutation (Cys145→Stop) in Bruton's tyrosine kinase is associated with newly diagnosed X-linked agammaglobulinemia in a 51-year-old male. Mol. Med. 2, 619–623 (1996).
  Article CAS Google Scholar
• Yao, L., Kawakami, Y. & Kawakami, T. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA 91, 9175–9179 (1994).
  Article CAS Google Scholar
• Salim, K. et al. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J. 15, 6241–6250 (1996).
  Article CAS Google Scholar
• Endo, T. A. et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921–924 (1997).
  Article CAS Google Scholar
• Starr, R. et al. A family of cytokine-inducible inhibitors of signalling. Nature 387, 917–921 (1997).
  Article CAS Google Scholar
• Vassilev, A., Ozer, Z., Navara, C., Mahajan, S. & Uckun, F. M. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J. Biol. Chem. 274, 1646–1656 (1999).
  Article CAS Google Scholar
• Futatani, T. et al. Deficient expression of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection. Blood 91, 595–602 (1998).
  CAS PubMed Google Scholar
• Hata, D. et al. Involvement of Bruton's tyrosine kinase in FcɛRI-dependent mast cell degranulation and cytokine production. J. Exp. Med. 187, 1235–1247 (1998).
  Article CAS Google Scholar
• Oda, A. et al. Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking. Blood 95, 1663–1670 (2000).
  CAS PubMed Google Scholar
• Guinamard, R., Aspenstrom, P., Fougereau, M., Chavrier, P. & Guillemot, J. C. Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42. FEBS Lett. 434, 431–436. (1998).
  Article CAS Google Scholar
• Ambrosino, C. et al. HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer–binding protein β (NF-IL6) transcription factors. J. Biol. Chem. 272, 14883–14892 (1997).
  Article CAS Google Scholar
• Stewart, D. M., Notarangelo, L. D., Kurman, C. C., Staudt, L. M. & Nelson, D. L. Molecular genetic analysis of X-linked hypogammaglobulinemia and isolated growth hormone deficiency. J. Immunol. 155, 2770–2774 (1995).
  CAS PubMed Google Scholar
• Giordano, V. et al. Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J. Immunol. 158, 4097–4103 (1997).
  CAS PubMed Google Scholar
• Rabin, R. L. et al. Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. J. Immunol. 162, 3840–3850 (1999).
  CAS PubMed Google Scholar
• Pine, R., Canova, A. & Schindler, C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN α and IFN γ, and is likely to autoregulate the p91 gene. EMBO J. 13, 158–167. (1994).
  Article CAS Google Scholar
• Chen, X. et al. Impaired generation of bone marrow B lymphocytes in mice deficient in C/EBPβ. Blood 90, 156–164. (1997).
  CAS PubMed Google Scholar
• Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245–2262. (1998).
  Article CAS Google Scholar