STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression (original) (raw)
Klein, U. et al. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA100, 2639–2644 (2003). ArticleCAS Google Scholar
Calame, K.L., Lin, K.I. & Tunyaplin, C. Regulatory mechanisms that determine the development and function of plasma cells. Annu. Rev. Immunol.21, 205–230 (2003). ArticleCAS Google Scholar
Tarlinton, D.M. & Smith, K.G. Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre. Immunol. Today21, 436–441 (2000). ArticleCAS Google Scholar
Stuber, E. & Strober, W. The T cell-B cell interaction via OX40–OX40L is necessary for the T cell-dependent humoral immune response. J. Exp. Med.183, 979–989 (1996). ArticleCAS Google Scholar
Turner, C.A., Jr., Mack, D.H. & Davis, M.M. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell77, 297–306 (1994). ArticleCAS Google Scholar
Reljic, R., Wagner, S.D., Peakman, L.J. & Fearon, D.T. Suppression of signal transducer and activator of transcription 3- dependent B lymphocyte terminal differentiation by BCL-6. J. Exp. Med.192, 1841–1848 (2000). ArticleCAS Google Scholar
Shaffer, A.L. et al. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity13, 199–212 (2000). ArticleCAS Google Scholar
Shaffer, A.L. et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity17, 51–62 (2002). ArticleCAS Google Scholar
Reimold, A.M. et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature412, 300–307 (2001). ArticleCAS Google Scholar
Arpin, C. et al. Generation of memory B cells and plasma cells in vitro. Science268, 720–722 (1995). ArticleCAS Google Scholar
Arpin, C., Banchereau, J. & Liu, Y.J. Memory B cells are biased towards terminal differentiation: a strategy that may prevent repertoire freezing. J. Exp. Med.186, 931–940 (1997). ArticleCAS Google Scholar
Shvarts, A. et al. A senescence rescue screen identifies BCL6 as an inhibitor of anti- proliferative p19(ARF)-p53 signaling. Genes Dev.16, 681–686 (2002). ArticleCAS Google Scholar
Fearon, D.T., Manders, P. & Wagner, S.D. Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. Science293, 248–250 (2001). ArticleCAS Google Scholar
Lischke, A. et al. The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain. J. Biol. Chem.273, 31222–31229 (1998). ArticleCAS Google Scholar
Rolling, C., Treton, D., Pellegrini, S., Galanaud, P. & Richard, Y. IL4 and IL13 receptors share the γ c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells. FEBS Lett.393, 53–56 (1996). ArticleCAS Google Scholar
Leonard, W.J. & O'Shea, J.J. Jaks and STATs: biological implications. Annu. Rev. Immunol.16, 293–322 (1998). ArticleCAS Google Scholar
Shimoda, K. et al. Lack of IL-4-induced TH2 response and IgE class switching in mice with disrupted Stat6 gene. Nature380, 630–633 (1996). ArticleCAS Google Scholar
Kaplan, M.H., Schindler, U., Smiley, S.T. & Grusby, M.J. STAT6 is required for mediating responses to IL-4 and for development of TH2 cells. Immunity4, 313–319 (1996). ArticleCAS Google Scholar
Teglund, S. et al. STAT5a and STAT5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell93, 841–850 (1998). ArticleCAS Google Scholar
Bunting, K.D. et al. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood99, 479–487 (2002). ArticleCAS Google Scholar
Sexl, V. et al. STAT5a/b contribute to interleukin 7-induced B-cell precursor expansion, but _abl_- and _bcr/abl_-induced transformation are independent of stat5. Blood96, 2277–2283 (2000). CASPubMed Google Scholar
Burchill, M.A. et al. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J. Immunol.171, 5853–5864 (2003). ArticleCAS Google Scholar
Lord, J.D., McIntosh, B.C., Greenberg, P.D. & Nelson, B.H. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of STAT5. J. Immunol.164, 2533–2541 (2000). ArticleCAS Google Scholar
John, S., Robbins, C.M. & Leonard, W.J. An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds STAT5, Elf-1, HMG-I(Y) and a GATA family protein. EMBO J.15, 5627–5635 (1996). ArticleCAS Google Scholar
Martinez-Valdez, H. et al. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J. Exp. Med.183, 971–977 (1996). ArticleCAS Google Scholar
Angelin-Duclos, C., Cattoretti, G., Lin, K.I. & Calame, K. Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. J. Immunol.165, 5462–5471 (2000). ArticleCAS Google Scholar
Tunyaplin, C. et al. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol.173, 1158–1165 (2004). ArticleCAS Google Scholar
Banchereau, J., de Paoli, P., Valle, A., Garcia, E. & Rousset, F. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science251, 70–72 (1991). ArticleCAS Google Scholar
Kurata, H., Lee, H.J., O'Garra, A. & Arai, N. Ectopic expression of activated Stat6 induces the expression of TH2- specific cytokines and transcription factors in developing TH1 cells. Immunity11, 677–688 (1999). ArticleCAS Google Scholar
Ohashi, K., Miki, T., Hirosawa, S. & Aoki, N. Characterization of the promoter region of human BCL-6 gene. Biochem. Biophys. Res. Commun.214, 461–467 (1995). ArticleCAS Google Scholar
Wolf, J. et al. Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells. Blood87, 3418–3428 (1996). CASPubMed Google Scholar
Hinz, M. et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J. Exp. Med.196, 605–617 (2002). ArticleCAS Google Scholar
Raman, V.S., Akondy, R.S., Rath, S., Bal, V. & George, A. Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responses. J. Immunol.171, 5876–5881 (2003). ArticleCAS Google Scholar
Raman, V.S., Bal, V., Rath, S. & George, A. Ligation of CD27 on murine B cells responding to T-dependent and T-independent stimuli inhibits the generation of plasma cells. J. Immunol.165, 6809–6815 (2000). ArticleCAS Google Scholar
Andjelic, S. et al. Phosphatidylinositol 3-kinase and NF-κB/Rel are at the divergence of CD40-mediated proliferation and survival pathways. J. Immunol.165, 3860–3867 (2000). ArticleCAS Google Scholar
Dadgostar, H. et al. Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc. Natl. Acad. Sci. USA99, 1497–1502 (2002). ArticleCAS Google Scholar
Ehret, G.B. et al. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J. Biol. Chem.276, 6675–6688 (2001). ArticleCAS Google Scholar
Lin, Y., Wong, K. & Calame, K. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science276, 596–599 (1997). ArticleCAS Google Scholar
Usui, T. et al. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J. Immunol.158, 3197–3204 (1997). CASPubMed Google Scholar
Reimold, A.M. et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature412, 300–307 (2001). ArticleCAS Google Scholar
Karras, J.G., Wang, Z., Coniglio, S.J., Frank, D.A. & Rothstein, T.L. Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-γ activation site. J. Immunol.157, 39–47 (1996). CASPubMed Google Scholar
Dent, A.L., Shaffer, A.L., Yu, X., Allman, D. & Staudt, L.M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science276, 589–592 (1997). ArticleCAS Google Scholar
Ye, B.H. et al. The bcl-6 proto-oncogene controls germinal-centre formation and TH2- type inflammation. Nat. Genet.16, 161–170 (1997). ArticleCAS Google Scholar
Fukuda, T. et al. Disruption of the bcl-6 gene results in an impaired germinal center formation. J. Exp. Med.186, 439–448 (1997). ArticleCAS Google Scholar
Toyama, H. et al. Memory B cells without somatic hypermutation are generated from _bcl-6_-deficient B cells. Immunity17, 329–339 (2002). ArticleCAS Google Scholar
Ariyoshi, K. et al. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem.275, 24407–24413 (2000). ArticleCAS Google Scholar
Heemskerk, M.H. et al. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J. Exp. Med.186, 1597–1602 (1997). ArticleCAS Google Scholar
Brummelkamp, T.R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science296, 550–553 (2002). ArticleCAS Google Scholar
Vyth-Dreese, F.A., Dellemijn, T.A., Majoor, D. & de Jong, D. Localization in situ of the co-stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue. Eur. J. Immunol.25, 3023–3029 (1995). ArticleCAS Google Scholar
Guikema, J.E. et al. Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantation. Br. J. Haematol.104, 748–754 (1999). ArticleCAS Google Scholar