Loss of adenomatous polyposis coli gene function disrupts thymic development (original) (raw)

• van de Wetering, M., de Lau, W. & Clevers, H. WNT signaling and lymphocyte development. Cell 109, S13–S19 (2002).
  Article CAS PubMed Google Scholar
• Morin, P.J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or Apc. Science 275, 1787–1790 (1997).
  Article CAS PubMed Google Scholar
• Smits, R. et al. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114, 275–283 (1998).
  Article CAS PubMed Google Scholar
• Sparks, A.B., Morin, P.J., Vogelstein, B. & Kinzler, K.W. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer. Cancer Res. 58, 1130–1134 (1998).
  CAS PubMed Google Scholar
• Miyoshi, Y. et al. Germ-line mutations of the Apc gene in 53 familial adenomatous polyposis patients. Proc. Natl. Acad. Sci. USA 89, 4452–4456 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Powell, S.M. et al. Molecular diagnosis of familial adenomatous polyposis. N. Engl. J. Med. 329, 1982–1987 (1993).
  Article CAS PubMed Google Scholar
• Miyaki, M. et al. Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis. Cancer Res. 53, 5079–5082 (1993).
  CAS PubMed Google Scholar
• Korinek, V. et al. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma. Science 275, 1784–1787 (1997).
  Article CAS PubMed Google Scholar
• Shih, I.M. et al. Top-down morphogenesis of colorectal tumors. Proc. Natl. Acad. Sci. USA 98, 2640–2645 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Kaplan, K.B. et al. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3, 429–432 (2001).
  Article CAS PubMed Google Scholar
• Fodde, R. et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell Biol. 3, 433–438 (2001).
  Article CAS PubMed Google Scholar
• Martin, C.H. et al. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat. Immunol. 4, 866–873 (2003).
  Article CAS PubMed Google Scholar
• Shortman, K. & Wu, L. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14, 29–47 (1996).
  Article CAS PubMed Google Scholar
• Allman, D. et al. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4, 168–174 (2003).
  Article CAS PubMed Google Scholar
• Schwarz, B.A. & Bhandoola, A. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5, 953–960 (2004).
  Article CAS PubMed Google Scholar
• Kondo, M., Weissman, I.L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661–672 (1997).
  Article CAS PubMed Google Scholar
• Porritt, H.E. et al. Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity 20, 735–745 (2004).
  Article CAS PubMed Google Scholar
• Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547–558 (1999).
  Article CAS PubMed Google Scholar
• Schmitt, T.M. & Zuniga-Pflucker, J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17, 749–756 (2002).
  Article CAS PubMed Google Scholar
• von Boehmer, H. Aspects of lymphocyte developmental biology. Immunol. Today 18, 260–262 (1997).
  Article CAS PubMed Google Scholar
• Wolfer, A., Wilson, A., Nemir, M., MacDonald, H.R. & Radtke, F. Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ Lineage Thymocytes. Immunity 16, 869–879 (2002).
  Article CAS PubMed Google Scholar
• Schilham, M.W. et al. Critical involvement of Tcf-1 in expansion of thymocytes. J. Immunol. 161, 3984–3991 (1998).
  CAS PubMed Google Scholar
• Ioannidis, V., Beermann, F., Clevers, H. & Held, W. The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival. Nat. Immunol. 2, 691–697 (2001).
  Article CAS PubMed Google Scholar
• Okamura, R.M. et al. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8, 11–20 (1998).
  Article CAS PubMed Google Scholar
• Xu, Y., Banerjee, D., Huelsken, J., Birchmeier, W. & Sen, J.M. Deletion of β-catenin impairs T cell development. Nat. Immunol. 4, 1177–1182 (2003).
  Article CAS PubMed Google Scholar
• Gounari, F. et al. Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development. Nat. Immunol. 2, 863–869 (2001).
  Article CAS PubMed Google Scholar
• Fodde, R. et al. A targeted chain-termination mutation in the mouse APC gene results in multiple intestinal tumors. Proc. Natl. Acad. Sci. USA 91, 8969–8973 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Moser, A.R., Pitot, H.C. & Dove, W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322–324 (1990).
  Article CAS PubMed Google Scholar
• Oshima, M. et al. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA 92, 4482–4486 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Harada, N. et al. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene. EMBO J. 18, 5931–5942 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Lee, P.P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763–774 (2001).
  Article CAS PubMed Google Scholar
• Moore, N.C., Anderson, G., Williams, G.T., Owen, J.J. & Jenkinson, E.J. Developmental regulation of bcl-2 expression in the thymus. Immunology 81, 115–119 (1994).
  CAS PubMed PubMed Central Google Scholar
• Anderson, S.J., Abraham, K.M., Nakayama, T., Singer, A. & Perlmutter, R.M. Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J. 11, 4877–4886 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Duncan, A.W. et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat. Immunol. 6, 314–322 (2005).
  Article CAS PubMed Google Scholar
• Galceran, J., Sustmann, C., Hsu, S.C., Folberth, S. & Grosschedl, R. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 18, 2718–2723 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Nicolas, M. et al. Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 33, 416–421 (2003).
  Article CAS PubMed Google Scholar
• Martinez Arias, A. Interactions between Wingless and Notch during the assignment of cell fates in Drosophila. Int. J. Dev. Biol. 42, 325–333 (1998).
  CAS PubMed Google Scholar
• Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451–461 (2003).
  Article CAS PubMed Google Scholar
• Aoki, K., Tamai, Y., Horiike, S., Oshima, M. & Taketo, M.M. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716_Cdx_2+/− compound mutant mice. Nat. Genet. 35, 323–330 (2003).
  Article CAS PubMed Google Scholar
• McDougall, S., Peterson, C.L. & Calame, K. A transcriptional enhancer 3′ of C β 2 in the T cell receptor β locus. Science 241, 205–208 (1988).
  Article CAS PubMed Google Scholar
• Su, L.K. et al. APC binds to the novel protein EB1. Cancer Res. 55, 2972–2977 (1995).
  CAS PubMed Google Scholar
• Zumbrunn, J., Kinoshita, K., Hyman, A.A. & Nathke, I.S. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 β phosphorylation. Curr. Biol. 11, 44–49 (2001).
  Article CAS PubMed Google Scholar
• Cleveland, D.W., Mao, Y. & Sullivan, K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112, 407–421 (2003).
  Article CAS PubMed Google Scholar
• Rieder, C.L., Schultz, A., Cole, R. & Sluder, G. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127, 1301–1310 (1994).
  Article CAS PubMed Google Scholar
• Li, X. & Nicklas, R.B. Mitotic forces control a cell-cycle checkpoint. Nature 373, 630–632 (1995).
  Article CAS PubMed Google Scholar
• Fehling, H.J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375, 795–798 (1995).
  Article CAS PubMed Google Scholar
• Hoffman, E.S. et al. Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10, 948–962 (1996).
  Article CAS PubMed Google Scholar
• Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172, 5230–5239 (2004).
  Article CAS PubMed Google Scholar
• Gounari, F. et al. Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene. Nat. Immunol. 3, 489–496 (2002).
  Article CAS PubMed Google Scholar
• Hodgkin, P.D. et al. The importance of efficacy and partial agonism in evaluating models of B lymphocyte activation. Int. Rev. Immunol. 15, 101–127 (1997).
  Article CAS PubMed Google Scholar