Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance (original) (raw)
Janeway, C.A., Jr. & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol.20, 197–216 (2002). ArticleCAS Google Scholar
Girardi, M. et al. Regulation of cutaneous malignancy by γδ T cells. Science294, 605–609 (2001). ArticleCAS Google Scholar
Cerwenka, A. et al. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity12, 721–727 (2000). ArticleCAS Google Scholar
Diefenbach, A., Jamieson, A.M., Liu, S.D., Shastri, N. & Raulet, D.H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol.1, 119–126 (2000). ArticleCAS Google Scholar
Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science285, 727–729 (1999). ArticleCAS Google Scholar
Jamieson, A.M. et al. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity17, 19–29 (2002). ArticleCAS Google Scholar
Pende, D. et al. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res.62, 6178–6186 (2002). CASPubMed Google Scholar
Groh, V. et al. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proc. Natl. Acad. Sci. USA96, 6879–6884 (1999). ArticleCAS Google Scholar
Vetter, C.S. et al. Expression of stress-induced MHC class I related chain molecules on human melanoma. J. Invest. Dermatol.118, 600–605 (2002). ArticleCAS Google Scholar
Cerwenka, A., Baron, J.L. & Lanier, L.L. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA98, 11521–11526 (2001). ArticleCAS Google Scholar
Diefenbach, A., Jensen, E.R., Jamieson, A.M. & Raulet, D.H. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature413, 165–171 (2001). ArticleCAS Google Scholar
Tieng, V. et al. Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl. Acad. Sci. USA99, 2977–2982 (2002). ArticleCAS Google Scholar
Groh, V. et al. Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol.2, 255–260 (2001). ArticleCAS Google Scholar
Cosman, D. et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity14, 123–133 (2001). ArticleCAS Google Scholar
Groh, V., Bruhl, A., El Gabalawy, H., Nelson, J.L. & Spies, T. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA100, 9452–9457 (2003). ArticleCAS Google Scholar
Ogasawara, K. et al. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity18, 41–51 (2003). ArticleCAS Google Scholar
Hue, S. et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity21, 367–377 (2004). Article Google Scholar
Meresse, B. et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity21, 357–366 (2004). ArticleCAS Google Scholar
Ogasawara, K. et al. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity20, 757–767 (2004). ArticleCAS Google Scholar
Groh, V., Wu, J., Yee, C. & Spies, T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature419, 734–738 (2002). ArticleCAS Google Scholar
Salih, H.R. et al. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood102, 1389–1396 (2003). ArticleCAS Google Scholar
Doubrovina, E.S. et al. Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J. Immunol.171, 6891–6899 (2003). ArticleCAS Google Scholar
Derynck, R., Akhurst, R.J. & Balmain, A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet.29, 117–129 (2001). ArticleCAS Google Scholar
Castriconi, R. et al. Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. USA100, 4120–4125 (2003). ArticleCAS Google Scholar
Lee, J.C., Lee, K.M., Kim, D.W. & Heo, D.S. Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J. Immunol.172, 7335–7340 (2004). ArticleCAS Google Scholar
Carroll, J.M., Albers, K.M., Garlick, J.A., Harrington, R. & Taichman, L.B. Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proc. Natl. Acad. Sci. USA90, 10270–10274 (1993). ArticleCAS Google Scholar
Kim, S. et al. In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol.3, 523–528 (2002). Article Google Scholar
Diebold, S.S. et al. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature424, 324–328 (2003). ArticleCAS Google Scholar
Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature413, 732–738 (2001). ArticleCAS Google Scholar
Johansson, S.E., Hall, H., Bjorklund, J. & Hoglund, P. Broadly impaired NK cell function in non-obese diabetic mice is partially restored by NK cell activation in vivo and by IL-12/IL-18 in vitro. Int. Immunol.16, 1–11 (2004). ArticleCAS Google Scholar
Karre, K. NK cells, MHC class I molecules and the missing self. Scand. J. Immunol.55, 221–228 (2002). ArticleCAS Google Scholar
Koller, B.H., Marrack, P., Kappler, J.W. & Smithies, O. Normal development of mice deficient in β2M, MHC class I proteins, and CD8+ T cells. Science248, 1227–1230 (1990). ArticleCAS Google Scholar
Kelly, A. et al. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature355, 641–644 (1992). ArticleCAS Google Scholar
Millrain, M. et al. Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis. J. Immunol.167, 3756–3764 (2001). ArticleCAS Google Scholar
Girardi, M. et al. Characterizing the protective component of the αβ T cell response to transplantable squamous cell carcinoma. J. Invest. Dermatol.122, 699–706 (2004). ArticleCAS Google Scholar
Salih, H.R., Rammensee, H.G. & Steinle, A. Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding. J. Immunol.169, 4098–4102 (2002). ArticleCAS Google Scholar
Smyth, M.J., Crowe, N.Y. & Godfrey, D.I. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int. Immunol.13, 459–463 (2001). ArticleCAS Google Scholar
Kiessling, R. & Haller, O. Natural killer cells in the mouse: an alternative immune surveillance mechanism? Contemp. Top. Immunobiol.8, 171–201 (1978). ArticleCAS Google Scholar
Martin-Fontecha, A. et al. Induced recruitment of NK cells to lymph nodes provides IFN-γ for T(H)1 priming. Nat. Immunol.5, 1260–1265 (2004). ArticleCAS Google Scholar
Girardi, M. et al. The distinct contributions of murine T cell receptor (TCR)γδ+ and TCRαβ+ T cells to different stages of chemically induced skin cancer. J. Exp. Med.198, 747–755 (2003). ArticleCAS Google Scholar
Gao, Y. et al. γδ T cells provide an early source of interferon γ in tumor immunity. J. Exp. Med.198, 433–442 (2003). ArticleCAS Google Scholar
Zuany-Amorim, C., Hastewell, J. & Walker, C. Toll-like receptors as potential therapeutic targets for multiple diseases. Nat. Rev. Drug Discov.1, 797–807 (2002). ArticleCAS Google Scholar
Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCRγδ+ and TCRαβ+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity15, 419–434 (2001). ArticleCAS Google Scholar
Carayannopoulos, L.N., Naidenko, O.V., Fremont, D.H. & Yokoyama, W.M. Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D. J. Immunol.169, 4079–4083 (2002). ArticleCAS Google Scholar
Stephens, H.A. MICA and MICB genes: can the enigma of their polymorphism be resolved? Trends Immunol.22, 378–385 (2001). ArticleCAS Google Scholar
Niwa, H., Yamamura, K. & Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene108, 193–199 (1991). ArticleCAS Google Scholar
Mallick-Wood, C.A. et al. Conservation of T cell receptor conformation in epidermal γδ cells with disrupted primary V-γ gene usage. Science279, 1729–1733 (1998). ArticleCAS Google Scholar
Findly, R.C., Roberts, S.J. & Hayday, A.C. Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria. Eur. J. Immunol.23, 2557–2564 (1993). ArticleCAS Google Scholar
Masuda, H. et al. High levels of RAE-1 isoforms on mouse tumor cell lines assessed by anti-”pan” RAE-1 antibody confer tumor susceptibility to NK cells. Biochem. Biophys. Res. Commun.290, 140–145 (2002). ArticleCAS Google Scholar
Coles, R.M., Mueller, S.N., Heath, W.R., Carbone, F.R. & Brooks, A.G. Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. J. Immunol.168, 834–838 (2002). ArticleCAS Google Scholar