The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells (original) (raw)

• Mosmann, T.R. & Coffman, R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145–173 (1989).
  Article CAS Google Scholar
• Glimcher, L.H. & Murphy, K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14, 1693–1711 (2000).
  CAS PubMed Google Scholar
• Murphy, K.M. et al. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18, 451–494 (2000).
  Article CAS Google Scholar
• Harrington, L.E. et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123–1132 (2005).
  Article CAS Google Scholar
• Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133–1141 (2005).
  Article CAS Google Scholar
• Weaver, C.T., Hatton, R.D., Mangan, P.R. & Harrington, L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821–852 (2007).
  Article CAS Google Scholar
• Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233–240 (2005).
  Article CAS Google Scholar
• Murphy, C.A. et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951–1957 (2003).
  Article CAS Google Scholar
• Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744–748 (2003).
  Article CAS Google Scholar
• Szabo, S.J., Sullivan, B.M., Peng, S.L. & Glimcher, L.H. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713–758 (2003).
  Article CAS Google Scholar
• Lighvani, A.A. et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98, 15137–15142 (2001).
  Article CAS Google Scholar
• Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol. 3, 549–557 (2002).
  Article CAS Google Scholar
• Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655–669 (2000).
  Article CAS Google Scholar
• Mullen, A.C. et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292, 1907–1910 (2001).
  Article CAS Google Scholar
• Murphy, K.M. et al. T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases. Curr. Top. Microbiol. Immunol. 238, 13–26 (1999).
  CAS PubMed Google Scholar
• Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817–824 (1997).
  Article CAS Google Scholar
• Mullen, A.C. et al. Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction. Nat. Immunol. 3, 652–658 (2002).
  Article CAS Google Scholar
• Usui, T., Nishikomori, R., Kitani, A. & Strober, W. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet. Immunity 18, 415–428 (2003).
  Article CAS Google Scholar
• Usui, T. et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J. Exp. Med. 203, 755–766 (2006).
  Article CAS Google Scholar
• Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179–189 (2006).
  Article CAS Google Scholar
• Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715–725 (2000).
  Article CAS Google Scholar
• Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644–658 (2006).
  Article CAS Google Scholar
• Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623–655 (2001).
  Article CAS Google Scholar
• Taki, S. et al. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6, 673–679 (1997).
  Article CAS Google Scholar
• Lohoff, M. et al. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 6, 681–689 (1997).
  Article CAS Google Scholar
• Liu, J., Cao, S., Herman, L.M. & Ma, X. Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-γ-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198, 1265–1276 (2003).
  Article CAS Google Scholar
• Maruyama, S. et al. Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter. J. Immunol. 170, 997–1001 (2003).
  Article CAS Google Scholar
• McElligott, D.L. et al. CD4+ T cells from IRF-1-deficient mice exhibit altered patterns of cytokine expression and cell subset homeostasis. J. Immunol. 159, 4180–4186 (1997).
  CAS PubMed Google Scholar
• Elser, B. et al. IFN-γ represses IL-4 expression via IRF-1 and IRF-2. Immunity 17, 703–712 (2002).
  Article CAS Google Scholar
• Hwang, E.S., Szabo, S.J., Schwartzberg, P.L. & Glimcher, L.H. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307, 430–433 (2005).
  Article CAS Google Scholar
• Yamane, H., Igarashi, O., Kato, T. & Nariuchi, H. Positive and negative regulation of IL-12 receptor expression of naive CD4+ T cells by CD28/CD152 co-stimulation. Eur. J. Immunol. 30, 3171–3180 (2000).
  Article CAS Google Scholar
• Szabo, S.J. et al. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295, 338–342 (2002).
  Article CAS Google Scholar
• Aggarwal, S., Ghilardi, N., Xie, M.H., de Sauvage, F.J. & Gurney, A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910–1914 (2003).
  Article CAS Google Scholar
• Mangan, P.R. et al. Transforming growth factor-beta induces development of the TH17 lineage. Nature 441, 231–234 (2006).
  Article CAS Google Scholar
• Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1, 553–562 (1994).
  Article CAS Google Scholar
• Wenner, C.A., Guler, M.L., Macatonia, S.E., O'Garra, A. & Murphy, K.M. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J. Immunol. 156, 1442–1447 (1996).
  CAS PubMed Google Scholar
• Musikacharoen, T. et al. Interleukin-15 induces IL-12 receptor β1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling. Blood 105, 711–720 (2005).
  Article CAS Google Scholar
• Zhang, F. & Boothby, M. T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-γ promoter are Stat4 dependent. J. Exp. Med. 203, 1493–1505 (2006).
  Article CAS Google Scholar
• Avni, O. et al. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3, 643–651 (2002).
  Article CAS Google Scholar
• te Velde, A.A. et al. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease. Inflamm. Bowel Dis. 13, 325–330 (2007).
  Article Google Scholar
• Silverberg, M.S. et al. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. Eur. J. Hum. Genet. 15, 328–335 (2007).
  Article CAS Google Scholar
• Clavell, M. et al. Detection of interferon regulatory factor-1 in lamina propria mononuclear cells in Crohn's disease. J. Pediatr. Gastroenterol. Nutr. 30, 43–47 (2000).
  Article CAS Google Scholar
• Matsuyama, T. et al. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75, 83–97 (1993).
  Article CAS Google Scholar
• Meraz, M.A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431–442 (1996).
  Article CAS Google Scholar
• Huang, S. et al. Immune response in mice that lack the interferon-γ receptor. Science 259, 1742–1745 (1993).
  Article CAS Google Scholar
• Wu, C., Ferrante, J., Gately, M.K. & Magram, J. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J. Immunol. 159, 1658–1665 (1997).
  CAS PubMed Google Scholar
• Honda, K. et al. Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. USA 100, 10872–10877 (2003).
  Article CAS Google Scholar
• Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9, 745–755 (1998).
  Article CAS Google Scholar
• Takayanagi, H. et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889–901 (2002).
  Article CAS Google Scholar
• Martin-Fontecha, A. et al. Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming. Nat. Immunol. 5, 1260–1265 (2004).
  Article CAS Google Scholar