Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene (original) (raw)

• Spangrude, G. J., Heimfeld, S. & Weissman, I. L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58–62 (1988).
  Article CAS Google Scholar
• Morrison, S. J. & Weissman, I. L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1, 661–673 (1994).
  Article CAS Google Scholar
• Weissman, I. L., Anderson, D. J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387–403 (2001).
  Article CAS Google Scholar
• Adolfsson, J. et al. Upregulation of Flt3 expression within the bone marrow Lin−Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15, 659–669 (2001).
  Article CAS Google Scholar
• Kondo, M., Weissman, I. L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661–672 (1997).
  Article CAS Google Scholar
• Fisher, R. C. & Scott, E. W. Role of PU.1 in hematopoiesis. Stem Cells 16, 25–37 (1998).
  Article CAS Google Scholar
• Urbanek, P., Wang, Z. Q., Fetka, I., Wagner, E. F. & Busslinger, M. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901–912 (1994).
  Article CAS Google Scholar
• O'Riordan, M. & Grosschedl, R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 11, 21–31 (1999).
  Article CAS Google Scholar
• Wilson, A., MacDonald, H. R. & Radtke, F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194, 1003–1012 (2001).
  Article CAS Google Scholar
• Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547–558 (1999).
  Article CAS Google Scholar
• Allman, D. et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med. 194, 99–106 (2001).
  Article CAS Google Scholar
• Pui, J. C. et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11, 299–308 (1999).
  Article CAS Google Scholar
• Jaleco, A. C. et al. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 194, 991–1002 (2001).
  Article CAS Google Scholar
• Groettrup, M. et al. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 75, 283–294 (1993).
  Article CAS Google Scholar
• Saint-Ruf, C. et al. Analysis and expression of a cloned pre-T cell receptor gene. Science 266, 1208–1212 (1994).
  Article CAS Google Scholar
• Deftos, M. L., Huang, E., Ojala, E. W., Forbush, K. A. & Bevan, M. J. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13, 73–84 (2000).
  Article CAS Google Scholar
• Reizis, B. & Leder, P. Direct induction of T lymphocyte specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16, 295–300 (2002).
  Article CAS Google Scholar
• Bruno, L., Rocha, B., Rolink, A., von Boehmer, H. & Rodewald, H. R. Intra- and extra-thymic expression of the pre-T cell receptor α gene. Eur. J. Immunol. 25, 1877–1882 (1995).
  Article CAS Google Scholar
• Martensson, I. L., Melchers, F. & Winkler, T. H. A transgenic marker for mouse B lymphoid precursors. J. Exp. Med. 185, 653–661 (1997).
  Article CAS Google Scholar
• Monroe, R. J. et al. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity 11, 201–212 (1999).
  Article CAS Google Scholar
• Yu, W. et al. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400, 682–687 (1999).
  Article CAS Google Scholar
• Reizis, B. & Leder, P. The upstream enhancer is necessary and sufficient for the expression of the Pre-T cell receptor α gene in immature T lymphocytes. J. Exp. Med. 194, 979–990 (2001).
  Article CAS Google Scholar
• Reizis, B. & Leder, P. Expression of the mouse pre-T cell receptor α gene is controlled by an upstream region containing a transcriptional enhancer. J. Exp. Med. 189, 1669–1678 (1999).
  Article CAS Google Scholar
• Nishi, M., Ishida, Y. & Honjo, T. Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice. Nature 331, 267–269 (1988).
  Article CAS Google Scholar
• Shortman, K. & Wu, L. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14, 29–47 (1996).
  Article CAS Google Scholar
• Wu, L., Antica, M., Johnson, G. R., Scollay, R. & Shortman, K. Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med. 174, 1617–1627 (1991).
  Article CAS Google Scholar
• Matsuzaki, Y. et al. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation. J. Exp. Med. 178, 1283–1292 (1993).
  Article CAS Google Scholar
• Aifantis, I. et al. On the role of the pre-T cell receptor in αβ versus γδ T lineage commitment. Immunity 9, 649–655 (1998).
  Article CAS Google Scholar
• Yu, W. et al. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2. Science 285, 1080–1084 (1999).
  Article CAS Google Scholar
• Hardy, R. R. & Hayakawa, K. B cell development pathways. Annu. Rev. Immunol. 19, 595–621 (2001).
  Article CAS Google Scholar
• Rolink, A. et al. A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183, 187–194 (1996).
  Article CAS Google Scholar
• Res, P. C., Couwenberg, F., Vyth-Dreese, F. A. & Spits, H. Expression of pTα mRNA in a committed dendritic cell precursor in the human thymus. Blood 94, 2647–2657 (1999).
  CAS PubMed Google Scholar
• Ikawa, T., Kawamoto, H., Fujimoto, S. & Katsura, Y. Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay. J. Exp. Med. 190, 1617–1626 (1999).
  Article CAS Google Scholar
• Kawamoto, H., Ohmura, K., Fujimoto, S. & Katsura, Y. Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver. J. Immunol. 162, 2725–2731 (1999).
  CAS PubMed Google Scholar
• Tudor, K. S., Payne, K. J., Yamashita, Y. & Kincade, P. W. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events. Immunity 12, 335–345 (2000).
  Article CAS Google Scholar
• Bruno, L., Seidl, T. & Lanzavecchia, A. Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8a+ and CD8a- dendritic cells. Eur. J. Immunol. 31, 3403–3412 (2001).
  Article CAS Google Scholar
• Asselin-Paturel, C. et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nature Immunol. 2, 1144–1150 (2001).
  Article CAS Google Scholar
• Wu, L. et al. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349, 71–74 (1991).
  Article CAS Google Scholar
• Bruno, L., Res, P., Dessing, M., Cella, M. & Spits, H. Identification of a committed T cell precursor population in adult human peripheral blood. J. Exp. Med. 185, 875–884 (1997).
  Article CAS Google Scholar
• Georgopoulos, K. Haematopoietic cell fate decisions, chromatin regulation and Ikaros. Nature Rev. Immunol. 2, 162–174 (2002).
  Article CAS Google Scholar
• Dejbakhsh-Jones, S., Jerabek, L., Weissman, I. L. & Strober, S. Extrathymic maturation of β T cells from hemopoietic stem cells. J. Immunol. 155, 3338–3344 (1995).
  CAS PubMed Google Scholar
• Douagi, I. I., Andre, I. I., Ferraz, J. C. & Cumano, A. Characterization of T cell precursor activity in the murine fetal thymus: evidence for an input of T cell precursors between days 12 and 14 of gestation. Eur. J. Immunol. 30, 2201–2210 (2000).
  Article CAS Google Scholar