c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation (original) (raw)

• Weiss, A. & Littman, D.R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263–274 (1994).
  Article CAS Google Scholar
• Lanzavecchia, A. & Sallusto, F. From synapses to immunological memory: the role of sustained T cell stimulation. Curr. Opin. Immunol. 12, 92–98 (2000).
  Article CAS Google Scholar
• Lanzavecchia, A. & Sallusto, F. Antigen decoding by T lymphocytes: from synapses to fate determination. Nature Immunol. 2, 487–492 (2001).
  Article CAS Google Scholar
• Clements, J.L., Boerth, N.J., Lee, J.R. & Koretzky, G.A. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu. Rev. Immunol. 17, 89–108 (1999).
  Article CAS Google Scholar
• Tomlinson, M.G., Lin, J. & Weiss, A. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunol. Today 21, 584–591 (2000).
  Article CAS Google Scholar
• Clements, J.L. et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281, 416–419 (1998).
  Article CAS Google Scholar
• Pivniouk, V. et al. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94, 229–238 (1998).
  Article CAS Google Scholar
• Zhang, W. et al. Essential role of LAT in T cell development. Immunity 10, 323–332 (1999).
  Article CAS Google Scholar
• Yoder, J. et al. Requirement for the SLP-76 adaptor GADS in T cell development. Science 291, 1987–1991 (2001).
  Article CAS Google Scholar
• Gong, Q. et al. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nature Immunol. 2, 29–36 (2001).
  Article CAS Google Scholar
• Lupher, M.L. Jr., Rao, N., Eck, M.J. & Band, H. The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol. Today 20, 375–382 (1999).
  Article CAS Google Scholar
• Thien, C.B. & Langdon, W.Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nature Rev. Mol. Cell Biol. 2, 294–307 (2001).
  Article CAS Google Scholar
• Waterman, H. & Yarden, Y. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett. 490, 142–152 (2001).
  Article CAS Google Scholar
• Meng, W., Sawasdikosol, S., Burakoff, S.J. & Eck, M.J. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature 398, 84–90 (1999).
  Article CAS Google Scholar
• Joazeiro, C.A. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286, 309–312 (1999).
  Article CAS Google Scholar
• Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4, 1029–1040 (1999).
  Article CAS Google Scholar
• Yokouchi, M. et al. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J. Biol. Chem. 274, 31707–31712 (1999).
  Article CAS Google Scholar
• Zheng, N., Wang, P., Jeffrey, P.D. & Pavletich, N.P. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102, 533–539 (2000).
  Article CAS Google Scholar
• Murphy, M.A. et al. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl–deficient mice. Mol. Cell. Biol. 18, 4872–4882 (1998).
  Article CAS Google Scholar
• Naramura, M., Kole, H.K., Hu, R.J. & Gu, H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl. Acad. Sci. USA 95, 15547–15552 (1998).
  Article CAS Google Scholar
• Bachmaier, K. et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211–216 (2000).
  Article CAS Google Scholar
• Chiang, Y.J. et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403, 216–220 (2000).
  Article CAS Google Scholar
• Fang, D. & Liu, Y.C. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nature Immunol. 2, 870–875 (2001).
  Article CAS Google Scholar
• Swain, S.L. et al. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123, 115–144 (1991).
  Article CAS Google Scholar
• Timmerman, L.A., Clipstone, N.A., Ho, S.N., Northrop, J.P. & Crabtree, G.R. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 383, 837–40 (1996).
  Article CAS Google Scholar
• Liu, H., Rhodes, M., Wiest, D.L. & Vignali, D.A. On the dynamics of TCR:CD3 complex cell surface expression and down-modulation. Immunity 13, 665–675 (2000).
  Article CAS Google Scholar
• Valitutti, S., Muller, S., Salio, M. & Lanzavecchia, A. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185, 1859–1864 (1997).
  Article CAS Google Scholar
• Lippincott-Schwartz, J. et al. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67, 601–616 (1991).
  Article CAS Google Scholar
• Lee, K.-H. et al. T cell receptor signaling precedes immunological synapse formation. Science 295, 1539–1542 (2002).
  Article CAS Google Scholar
• Zerial, M. & McBride, H. Rab proteins as membrane organizers. Nature Rev. Mol. Cell Biol. 2, 107–117 (2001).
  Article CAS Google Scholar
• Corvera, S. & Czech, M.P. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol. 8, 442–446 (1998).
  Article CAS Google Scholar
• Miyake, S. et al. The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. Crit. Rev. Oncog. 8, 189–218 (1997).
  Article CAS Google Scholar
• Fang, D. et al. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3- kinase for ubiquitination in T cells. J. Biol. Chem. 276, 4872–4878 (2001).
  Article CAS Google Scholar
• Babst, M., Odorizzi, G., Estepa, E.J. & Emr, S.D. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 1, 248–258 (2000).
  Article CAS Google Scholar
• Wang, H.-Y. et al. Cbl Promotes Ubiquitination of the T cell receptor ζ through an adaptor function of Zap-70. J. Biol. Chem. 276, 26004–26011 (2001).
  Article CAS Google Scholar
• Petrelli, A. et al. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature 416, 187–90 (2002).
  Article CAS Google Scholar
• Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W.Y. & Dikic, I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 416, 183–187 (2002).
  Article CAS Google Scholar
• Baker, J.E., Majeti, R., Tangye, S.G. & Weiss, A. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase C-γ1 Phosphorylation. Mol. Cell. Biol. 21, 2393–2403 (2001).
  Article CAS Google Scholar
• Takahama, Y. et al. Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell- specific disruption of the Pig-a gene. Eur. J. Immunol. 28, 2159–2166 (1998).
  Article CAS Google Scholar
• Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. & Strober, W. Current Protocols in Immunology (ed. Coico, R.) (John Wiley & Sons, New York, 1992).
  Google Scholar