Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function (original) (raw)
Martin, F., Oliver, A.M. & Kearney, J.F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity14, 617–629 (2001). ArticleCAS Google Scholar
Berland, R. & Wortis, H.H. Origins and functions of B-1 cells with notes on the role of CD5. Annu. Rev. Immunol.20, 253–300 (2002). ArticleCAS Google Scholar
Fruman, D.A., Satterthwaite, A.B. & Witte, O.N. Xid-like phenotypes: a B cell signalosome takes shape. Immunity13, 1–3 (2000). ArticleCAS Google Scholar
Turner, M. & Billadeau, D.D. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat. Rev. Immunol.2, 476–486 (2002). ArticleCAS Google Scholar
Anderson, K.E., Coadwell, J., Stephens, L.R. & Hawkins, P.T. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr. Biol.8, 684–691 (1998). ArticleCAS Google Scholar
Fruman, D.A. & Cantley, L.C. Phosphoinositide 3-kinase in immunological systems. Semin. Immunol.14, 7–18 (2002). ArticleCAS Google Scholar
Fruman, D.A. et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science283, 393–397 (1999). ArticleCAS Google Scholar
Suzuki, H. et al. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science283, 390–392 (1999). ArticleCAS Google Scholar
Okkenhaug, K. et al. Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice. Science297, 1031–1034 (2002). CAS Google Scholar
Clayton, E. et al. A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med.196, 753–763 (2002). ArticleCAS Google Scholar
Tuveson, D.A., Carter, R.H., Soltoff, S.P. & Fearon, D.T. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science260, 986–989 (1993). ArticleCAS Google Scholar
Wang, Y. et al. The physiologic role of CD19 cytoplasmic tyrosines. Immunity17, 501–514 (2002). ArticleCAS Google Scholar
Buhl, A.M., Pleiman, C.M., Rickert, R.C. & Cambier, J.C. Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J. Exp. Med.186, 1897–1910 (1997). ArticleCAS Google Scholar
Buhl, A.M. & Cambier, J.C. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J. Immunol.162, 4438–4446 (1999). CASPubMed Google Scholar
Otero, D.C., Omori, S.A. & Rickert, R.C. CD19-dependent activation of Akt kinase in B-lymphocytes. J. Biol. Chem.276, 1474–1478 (2001). ArticleCAS Google Scholar
Fujimoto, M. et al. Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. J. Immunol.168, 5465–5476 (2002). ArticleCAS Google Scholar
Engel, P. et al. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity3, 39–50 (1995). ArticleCAS Google Scholar
Rickert, R.C., Rajewsky, K. & Roes, J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature376, 352–355 (1995). ArticleCAS Google Scholar
Martin, F. & Kearney, J.F. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity12, 39–49 (2000). ArticleCAS Google Scholar
Rameh, L.E. & Cantley, L.C. The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem.274, 8347–8350 (1999). ArticleCAS Google Scholar
Leslie, N.R. & Downes, C.P. PTEN: the down side of PI 3-kinase signalling. Cell. Signal.14, 285–295 (2002). ArticleCAS Google Scholar
Stambolic, V. et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell95, 29–39 (1998). ArticleCAS Google Scholar
Groszer, M. et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science294, 2186–2189 (2001). ArticleCAS Google Scholar
Lesche, R. et al. Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis32, 148–149 (2002). ArticleCAS Google Scholar
Rickert, R.C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res.25, 1317–1318 (1997). ArticleCAS Google Scholar
Rickert, P., Weiner, O.D., Wang, F., Bourne, H.R. & Servant, G. Leukocytes navigate by compass: roles of PI3Kγ and its lipid products. Trends Cell. Biol.10, 466–473 (2000). ArticleCAS Google Scholar
Cariappa, A. et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity14, 603–615 (2001). ArticleCAS Google Scholar
Lu, T.T. & Cyster, J.G. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science297, 409–412 (2002). ArticleCAS Google Scholar
Oliver, A.M., Martin, F., Gartland, G.L., Carter, R.H. & Kearney, J.F. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol.27, 2366–2374 (1997). ArticleCAS Google Scholar
Jones, S.M. & Kazlauskas, A. Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat. Cell Biol.3, 165–172 (2001). ArticleCAS Google Scholar
Fearon, D.T. & Carroll, M.C. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu. Rev. Immunol.18, 393–422 (2000). ArticleCAS Google Scholar
Beitz, L.O., Fruman, D.A., Kurosaki, T., Cantley, L.C. & Scharenberg, A.M. SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J. Biol. Chem.274, 32662–32666 (1999). ArticleCAS Google Scholar
Kurosaki, T. Regulation of B-cell signal transduction by adaptor proteins. Nat. Rev. Immunol.2, 354–363 (2002). ArticleCAS Google Scholar
Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K. & Kurosaki, T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity13, 817–827 (2000). ArticleCAS Google Scholar
Yamazaki, T. et al. Essential immunoregulatory role for BCAP in B cell development and function. J. Exp. Med.195, 535–545 (2002). ArticleCAS Google Scholar
Funamoto, S., Meili, R., Lee, S., Parry, L. & Firtel, R.A. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell109, 611–623 (2002). ArticleCAS Google Scholar
Iijima, M. & Devreotes, P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell109, 599–610 (2002). ArticleCAS Google Scholar
Giancotti, F.G. & Ruoslahti, E. Integrin signaling. Science285, 1028–1032 (1999). ArticleCAS Google Scholar
Reiske, H.R. et al. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J. Biol. Chem.274, 12361–12366 (1999). ArticleCAS Google Scholar
Klingbeil, C.K. et al. Targeting Pyk2 to β 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J. Cell. Biol.152, 97–110 (2001). ArticleCAS Google Scholar
Guinamard, R., Okigaki, M., Schlessinger, J. & Ravetch, J.V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat. Immunol.1, 31–36 (2000). ArticleCAS Google Scholar
Lam, E.W. et al. Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J. Biol. Chem.275, 3479–3484 (2000). ArticleCAS Google Scholar
Solvason, N. et al. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. Int. Immunol.12, 631–638 (2000). ArticleCAS Google Scholar
Glassford, J. et al. Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen receptor. J. Biol. Chem.276, 41040–41048 (2001). ArticleCAS Google Scholar
Su, T.T. & Rawlings, D.J. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J. Immunol.168, 2101–2110 (2002). ArticleCAS Google Scholar
Schwartz, M.A. & Assoian, R.K. Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J. Cell. Sci.114, 2553–2560 (2001). CASPubMed Google Scholar
Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell96, 857–868 (1999). ArticleCAS Google Scholar
Kops, G.J. et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature398, 630–634 (1999). ArticleCAS Google Scholar
Medema, R.H., Kops, G.J., Bos, J.L. & Burgering, B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature404, 782–787 (2000). ArticleCAS Google Scholar
Blain, S.W. & Massague, J. Breast cancer banishes p27 from nucleus. Nat. Med.8, 1076–1078 (2002). ArticleCAS Google Scholar
del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science278, 687–689 (1997). ArticleCAS Google Scholar
Helgason, C.D. et al. A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of B lymphocytes in SHIP−/− mice. J. Exp. Med.191, 781–794 (2000). ArticleCAS Google Scholar
Brauweiler, A. et al. Differential regulation of B cell development, activation, and death by the Src homology 2 domain-containing 5′ inositol phosphatase (SHIP). J. Exp. Med.191, 1545–1554 (2000). ArticleCAS Google Scholar