TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways (original) (raw)

• Germain, R.N. & Margulies, D.H. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11, 403–450 (1993).
  Article CAS PubMed Google Scholar
• McKeithan, T.W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92, 5042–5046 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Jameson, S.C. & Bevan, M.J. T cell receptor antagonists and partial agonists. Immunity 2, 1–11 (1995).
  Article CAS PubMed Google Scholar
• Madrenas, J. & Germain, R.N. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin. Immunol. 8, 83–101 (1996).
  Article CAS PubMed Google Scholar
• Sloan-Lancaster, J., Shaw, A.S., Rothbard, J.B. & Allen, P.M. Partial T cell signaling: altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79, 913–922 (1994).
  Article CAS PubMed Google Scholar
• Madrenas, J. et al. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267, 515–518 (1995).
  Article CAS PubMed Google Scholar
• Reis e Sousa, C., Levine, E.H. & Germain, R.N. Partial signaling by CD8+ T cells in response to antagonist ligands. J. Exp. Med. 184, 149–157 (1996).
  Article CAS PubMed Google Scholar
• Hemmer, B., Štefanová, I., Vergelli, M., Germain, R.N. & Martin, R. Relationships among T cell receptor ligand potency, thresholds for effector function, and the quality of early signaling events in human T cells. J. Immunol. 160, 5807–5814 (1998).
  CAS PubMed Google Scholar
• Kersh, E.N., Shaw, A.S. & Allen, P.M. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281, 572–575 (1998).
  Article CAS PubMed Google Scholar
• De Magistris, M.T. et al. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68, 625–634 (1992).
  Article CAS PubMed Google Scholar
• Jameson, S.C., Carbone, F.R. & Bevan, M.J. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177, 1541–1550 (1993).
  Article CAS PubMed Google Scholar
• Racioppi, L., Ronchese, F., Matis, L.A. & Germain, R.N. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177, 1047–1060 (1993).
  Article CAS PubMed Google Scholar
• Stotz, S.H., Bolliger, L., Carbone, F.R. & Palmer, E. T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs. J. Exp. Med. 189, 253–264 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Daniels, M.A., Schober, S.L., Hogquist, K.A. & Jameson, S.C. Cutting edge: a test of the dominant negative signal model for TCR antagonism. J. Immunol. 162, 3761–3764 (1999).
  CAS PubMed Google Scholar
• Robertson, J.M. & Evavold, B.D. Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities. J. Immunol. 163, 1750–1754 (1999).
  CAS PubMed Google Scholar
• Dittel, B.N., Štefanová, I., Germain, R.N. & Janeway, C.A., Jr. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11, 289–298 (1999).
  Article CAS PubMed Google Scholar
• Pani, G., Fischer, K.D., Mlinaric-Rascan, I. & Siminovitch, K.A. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J. Exp. Med. 184, 839–852 (1996).
  Article CAS PubMed Google Scholar
• Plas, D.R. et al. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272, 1173–1176 (1996).
  Article CAS PubMed Google Scholar
• Plas, D.R. et al. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. J. Immunol. 162, 5680–5684 (1999).
  CAS PubMed Google Scholar
• Rabinowitz, J.D. et al. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity 5, 125–135 (1996).
  Article CAS PubMed Google Scholar
• Wülfing, C. et al. Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med. 185, 1815–1825 (1997).
  Article PubMed PubMed Central Google Scholar
• Raab, M. & Rudd, C.E. Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor z chain. Biochem. Biophys. Res. Commun. 222, 50–57 (1996).
  Article CAS PubMed Google Scholar
• Chiang, G.G. & Sefton, B.M. Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase. J. Biol. Chem. 276, 23173–23178 (2001).
  Article CAS PubMed Google Scholar
• Lorenz, U. et al. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. Mol. Cell. Biol. 14, 1824–1834 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Songyang, Z. et al. SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767–778 (1993).
  Article CAS PubMed Google Scholar
• Winkler, D.G. et al. Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck. Proc. Natl. Acad. Sci. USA 90, 5176–5180 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Watts, J.D., Sanghera, J.S., Pelech, S.L. & Aebersold, R. Phosphorylation of serine 59 of p56lck in activated T cells. J. Biol. Chem. 268, 23275–23282 (1993).
  CAS PubMed Google Scholar
• Joung, I. et al. Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain. Proc. Natl. Acad. Sci. USA 92, 5778–5782 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Ding, Y.H., Baker, B.M., Garboczi, D.N., Biddison, W.E. & Wiley, D.C. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity 11, 45–56 (1999).
  Article CAS PubMed Google Scholar
• Robey, E. & Fowlkes, B.J. Selective events in T cell development. Annu. Rev. Immunol. 12, 675–705 (1994).
  Article CAS PubMed Google Scholar
• Sette, A. et al. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu. Rev. Immunol. 12, 413–431 (1994).
  Article CAS PubMed Google Scholar
• Sloan-Lancaster, J., Steinberg, T.H. & Allen, P.M. Selective activation of the calcium signaling pathway by altered peptide ligands. J. Exp. Med. 184, 1525–1530 (1996).
  Article CAS PubMed Google Scholar
• Matsui, K., Boniface, J.J., Steffner, P., Reay, P.A. & Davis, M.M. Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 91, 12862–12866 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Alam, S.M. et al. T-cell-receptor affinity and thymocyte positive selection. Nature 381, 616–620 (1996).
  Article CAS PubMed Google Scholar
• Lyons, D.S. et al. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53–61 (1996).
  Article CAS PubMed Google Scholar
• Koyasu, S. et al. Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains. Proc. Natl. Acad. Sci. USA 91, 6693–6697 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Gauen, L.K. et al. Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol. Cell. Biol. 14, 3729–3741 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, H. & Vignali, D.A. Differential CD3 ζ phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands. J. Immunol. 163, 599–602 (1999).
  CAS PubMed Google Scholar
• Micheletti, F. et al. Supra-agonist peptides enhance the reactivation of memory CTL responses. J. Immunol. 165, 4264–4271 (2000).
  Article CAS PubMed Google Scholar
• Wülfing, C. et al. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat. Immunol. 3, 42–47 (2002).
  Article PubMed CAS Google Scholar
• Ferrell, J.E., Jr. & Machleder, E.M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280, 895–898 (1998).
  Article CAS PubMed Google Scholar
• Bray, D., Levin, M.D. & Morton-Firth, C.J. Receptor clustering as a cellular mechanism to control sensitivity. Nature 393, 85–88 (1998).
  Article CAS PubMed Google Scholar
• Chan, C., George, A.J. & Stark, J. Cooperative enhancement of specificity in a lattice of T cell receptors. Proc. Natl. Acad. Sci. USA 98, 5758–5763 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Alberola-Ila, J., Forbush, K.A., Seger, R., Krebs, E.G. & Perlmutter, R.M. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373, 620–623 (1995).
  Article CAS PubMed Google Scholar
• Alberola-Ila, J., Hogquist, K.A., Swan, K.A., Bevan, M.J. & Perlmutter, R.M. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184, 9–18 (1996).
  Article CAS PubMed Google Scholar
• Sharp, L.L., Schwarz, D.A., Bott, C.M., Marshall, C.J. & Hedrick, S.M. The influence of the MAPK pathway on T cell lineage commitment. Immunity 7, 609–618 (1997).
  Article CAS PubMed Google Scholar
• Bommhardt, U., Basson, M.A., Krummrei, U. & Zamoyska, R. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus. J. Immunol. 163, 715–722 (1999).
  CAS PubMed Google Scholar
• Yasutomo, K., Doyle, C., Miele, L. & Germain, R.N. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature 404, 506–510 (2000).
  Article CAS PubMed Google Scholar
• Pages, G. et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 1374–1377 (1999).
  Article CAS PubMed Google Scholar
• Lin, F.T., Miller, W.E., Luttrell, L.M. & Lefkowitz, R.J. Feedback regulation of β-arrestin1 function by extracellular signal-regulated kinases. J. Biol. Chem. 274, 15971–15974 (1999).
  Article CAS PubMed Google Scholar
• Hughes, P.E. et al. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88, 521–530 (1997).
  Article CAS PubMed Google Scholar
• Loeb, D.M., Tsao, H., Cobb, M.H. & Greene, L.A. NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk. Neuron 9, 1053–1065 (1992).
  Article CAS PubMed Google Scholar
• Xu, R., Seger, R. & Pecht, I. Cutting edge: extracellular signal-regulated kinase activates syk: A new potential feedback regulation of Fcε receptor signaling. J. Immunol. 163, 1110–1114 (1999).
  CAS PubMed Google Scholar
• Seder, R.A., Paul, W.E., Davis, M.M. & Fazekas de St. Groth, B. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 176, 1091–1098 (1992).
  Article CAS PubMed Google Scholar
• Shinkai, Y. et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855–867 (1992).
  Article CAS PubMed Google Scholar
• Ding, L., Linsley, P.S., Huang, L.Y., Germain, R.N. & Shevach, E.M. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151, 1224–1234 (1993).
  CAS PubMed Google Scholar
• Utz, U., Banks, D., Jacobson, S. & Biddison, W.E. Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. J. Virol. 70, 843–851 (1996).
  CAS PubMed PubMed Central Google Scholar
• Yi, T.L., Cleveland, J.L. & Ihle, J.N. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol. Cell. Biol. 12, 836–846 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Abraham, N. & Veillette, A. Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation. Mol. Cell. Biol. 10, 5197–5206 (1990).
  Article CAS PubMed PubMed Central Google Scholar
• Van Parijs, L. et al. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11, 281–288 (1999).
  Article CAS PubMed Google Scholar
• Itoh, Y. & Germain, R.N. Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. J. Exp. Med. 186, 757–766 (1997).
  Article CAS PubMed PubMed Central Google Scholar