Notch3 signaling promotes the development of pulmonary arterial hypertension (original) (raw)

• Owens, G.K., Kumar, M.S. & Wamhoff, B.R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev. 84, 767–801 (2004).
  Article CAS Google Scholar
• Yuan, J.X.-J. & Rubin, L.J. Pathogenesis of pulmonary arterial hypertension: the need for multiple hits. Circulation 111, 534–538 (2005).
  Article Google Scholar
• Hyduk, A. et al. Pulmonary hypertension surveillance—United States, 1980–2002. MMWR Surveill. Summ. 54, 1–28 (2005).
  PubMed Google Scholar
• Simonneau, G. et al. Clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 43, 5S–12S (2004).
  Article Google Scholar
• Alva, J.A. & Iruela-Arispe, M.L. Notch signaling in vascular morphogenesis. Curr. Opin. Hematol. 11, 278–283 (2004).
  Article CAS Google Scholar
• de la Pompa, J.L. et al. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124, 1139–1148 (1997).
  CAS Google Scholar
• Kopan, R., Nye, J.S. & Weintraub, H. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120, 2385–2396 (1994).
  CAS PubMed Google Scholar
• Proweller, A., Pear, W.S. & Parmacek, M.S. Notch signaling represses myocardin-induced smooth muscle cell differentiation. J. Biol. Chem. 280, 8994–9004 (2005).
  Article CAS Google Scholar
• Havrda, M.C., Johnson, M.J., O'Neill, C.F. & Liaw, L. A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells. Thromb. Haemost. 96, 361–370 (2006).
  Article CAS Google Scholar
• Wang, W., Prince, C.Z., Hu, X. & Pollman, M.J. HRT1 modulates vascular smooth muscle cell proliferation and apoptosis. Biochem. Biophys. Res. Commun. 308, 596–601 (2003).
  Article CAS Google Scholar
• Jin, S. et al. Notch regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. Circ. Res. 102, 1483–1491 (2008).
  Article CAS Google Scholar
• Roca, C. & Adams, R.H. Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 21, 2511–2524 (2007).
  Article CAS Google Scholar
• Campos, A.H., Wang, W., Pollman, M.J. & Gibbons, G.H. Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells—implications in cell-cycle regulation. Circ. Res. 91, 999–1006 (2002).
  Article CAS Google Scholar
• Morrow, D. et al. Notch-mediated CBF-1/RBP-Jk–dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am. J. Physiol. Cell Physiol. 289, C1188–C1196 (2005).
  Article CAS Google Scholar
• Domenga, V. et al. Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev. 18, 2730–2735 (2004).
  Article CAS Google Scholar
• Joutel, A. et al. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J. Clin. Invest. 105, 597–605 (2000).
  Article CAS Google Scholar
• Krebs, L.T. et al. Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis 37, 139–143 (2003).
  Article CAS Google Scholar
• Tuchscherer, H.A., Vanderpool, R.R. & Chesler, N.C. Pulmonary vascular remodeling in isolated mouse lungs: effects on pulsatile pressure-flow relationships. J. Biomech. 40, 993–1001 (2007).
  Article Google Scholar
• Chantemèle, E.J. et al. Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arterioscler. Thromb. Vasc. Biol. 28, 2216–2224 (2008).
  Article Google Scholar
• Hellström, M. et al. Dll4 signaling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445, 776–780 (2007).
  Article Google Scholar
• Real, P.J. et al. γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat. Med. 15, 50–58 (2009).
  Article CAS Google Scholar
• Eddahibi, S. et al. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J. Clin. Invest. 108, 1141–1150 (2001).
  Article CAS Google Scholar
• Du, L. et al. Signaling molecules in nonfamilial pulmonary hypertension. N. Engl. J. Med. 348, 500–509 (2003).
  Article CAS Google Scholar
• Hausmann, G. et al. An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J. Clin. Invest. 118, 1846–1857 (2008).
  Article Google Scholar
• Thomas, M. et al. Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am. J. Pathol. 174, 380–389 (2009).
  Article CAS Google Scholar
• Broughton, B.R., Walker, B.R. & Resta, T.C. Chronic hypoxia induces Rho kinase–dependent myogenic tone in small pulmonary arteries. Am. J. Physiol. Lung Cell Mol. Physiol. 294, L797–L806 (2008).
  Article CAS Google Scholar
• Sakata, Y. et al. Transcription factor CHF/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler. Thromb. Vasc. Biol. 24, 2069–2074 (2004).
  Article CAS Google Scholar
• Li, Y. et al. Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation 119, 2686–2692 (2009).
  Article CAS Google Scholar
• Morrow, D. et al. Notch and vascular smooth muscle phenotype. Circ. Res. 103, 1370–1382 (2008).
  Article CAS Google Scholar
• Deng, Z. et al. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am. J. Hum. Genet. 67, 737–744 (2000).
  Article CAS Google Scholar
• Lane, K.B. et al. Heterozygous germline mutations in BMPR2, encoding TGF-β receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat. Genet. 26, 81–84 (2000).
  Article CAS Google Scholar
• Blokzijl, A. et al. Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J. Cell Biol. 163, 723–728 (2003).
  Article CAS Google Scholar
• Bai, G. et al. Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev. Cell 13, 283–297 (2007).
  Article CAS Google Scholar
• Klüppel, M. & Wrana, J.L. Turning it up a notch: cross-talk between TGFβ and notch signaling. Bioessays 27, 115–118 (2005).
  Article Google Scholar
• Itoh, F. et al. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 23, 541–551 (2004).
  Article CAS Google Scholar
• Lin, Q., Lee, Y.J. & Yun, Z. Differentiation arrest by hypoxia. J. Biol. Chem. 281, 30678–30683 (2006).
  Article CAS Google Scholar
• Gustafsson, M.V. et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev. Cell 9, 617–628 (2005).
  Article CAS Google Scholar
• Sullivan, C.C. et al. Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Proc. Natl. Acad. Sci. USA 100, 12331–12336 (2003).
  Article CAS Google Scholar
• Yu, Y. et al. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc. Natl. Acad. Sci. USA 101, 13861–13866 (2004).
  Article CAS Google Scholar
• Zhang, L. et al. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J. Biol. Chem. 283, 4304–4313 (2008).
  Article CAS Google Scholar