Methylation determines fibroblast activation and fibrogenesis in the kidney (original) (raw)

• Eddy, A.A. Molecular insights into renal interstitial fibrosis. J. Am. Soc. Nephrol. 7, 2495–2508 (1996).
  CAS PubMed Google Scholar
• Kuncio, G.S., Neilson, E.G. & Haverty, T. Mechanisms of tubulointerstitial fibrosis. Kidney Int. 39, 550–556 (1991).
  Article CAS PubMed Google Scholar
• Strutz, F. & Zeisberg, M. Renal fibroblasts and myofibroblasts in chronic kidney disease. J. Am. Soc. Nephrol. 17, 2992–2998 (2006).
  Article CAS PubMed Google Scholar
• Kalluri, R. & Zeisberg, M. Fibroblasts in cancer. Nat. Rev. Cancer 6, 392–401 (2006).
  Article CAS PubMed Google Scholar
• Müller, G.A. & Rodemann, H.P. Characterization of human renal fibroblasts in health and disease: I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis. Am. J. Kidney Dis. 17, 680–683 (1991).
  Article PubMed Google Scholar
• Rodemann, H.P. & Müller, G.A. Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. Am. J. Kidney Dis. 17, 684–686 (1991).
  Article CAS PubMed Google Scholar
• Weber, K.T. & Brilla, C.G. Factors associated with reactive and reparative fibrosis of the myocardium. Basic Res. Cardiol. 87, Suppl 1, 291–301 (1992).
  PubMed Google Scholar
• Hinz, B. et al. The myofibroblast: one function, multiple origins. Am. J. Pathol. 170, 1807–1816 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Lafyatis, R. Targeting fibrosis in systemic sclerosis. Endocr. Metab. Immune Disord. Drug Targets 6, 395–400 (2006).
  Article CAS PubMed Google Scholar
• Lin, J. et al. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat. Med. 11, 387–393 (2005).
  Article CAS PubMed Google Scholar
• Santini, V., Kantarjian, H.M. & Issa, J.P. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann. Intern. Med. 134, 573–586 (2001).
  Article CAS PubMed Google Scholar
• Bird, A.P. & Wolffe, A.P. Methylation-induced repression—belts, braces, and chromatin. Cell 99, 451–454 (1999).
  Article CAS PubMed Google Scholar
• Feinberg, A.P. & Vogelstein, B. Alterations in DNA methylation in human colon neoplasia. Semin. Surg. Oncol. 3, 149–151 (1987).
  Article CAS PubMed Google Scholar
• Herman, J.G. & Baylin, S.B. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349, 2042–2054 (2003).
  Article CAS PubMed Google Scholar
• Jones, P.A. & Baylin, S.B. The epigenomics of cancer. Cell 128, 683–692 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Clark, S.J., Statham, A., Stirzaker, C., Molloy, P.L. & Frommer, M. DNA methylation: bisulphite modification and analysis. Nat. Protoc. 1, 2353–2364 (2006).
  Article CAS PubMed Google Scholar
• Gius, D. et al. The epigenome as a molecular marker and target. Cancer 104, 1789–1793 (2005).
  Article CAS PubMed Google Scholar
• Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11–22 (2003).
  Article CAS PubMed Google Scholar
• Mitin, N., Rossman, K.L. & Der, C.J. Signaling interplay in Ras superfamily function. Curr. Biol. 15, R563–R574 (2005).
  Article CAS PubMed Google Scholar
• Walker, S.A. et al. Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. EMBO J. 23, 1749–1760 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Barbacid, M. Ras genes. Annu. Rev. Biochem. 56, 779–827 (1987).
  Article CAS PubMed Google Scholar
• Bos, J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49, 4682–4689 (1989).
  CAS PubMed Google Scholar
• Arun, D. & Gutmann, D.H. Recent advances in neurofibromatosis type 1. Curr. Opin. Neurol. 17, 101–105 (2004).
  Article CAS PubMed Google Scholar
• Kolfschoten, I.G. et al. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell 121, 849–858 (2005).
  Article CAS PubMed Google Scholar
• Jin, H. et al. Epigenetic silencing of a Ca2+-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc. Natl. Acad. Sci. USA 104, 12353–12358 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Gazin, C., Wajapeyee, N., Gobeil, S., Virbasius, C.M. & Green, M.R. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449, 1073–1077 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Lloyd, C.M. et al. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med. 185, 1371–1380 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Zeisberg, M. et al. BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 9, 964–968 (2003).
  Article CAS PubMed Google Scholar
• Witzgall, R., Brown, D., Schwarz, C. & Bonventre, J.V. Localization of proliferating cell nuclear antigen, vimentin, c-Fos and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J. Clin. Invest. 93, 2175–2188 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Oliver, J.A., Maarouf, O., Cheema, F.H., Martens, T.P. & Al-Awqati, Q. The renal papilla is a niche for adult kidney stem cells. J. Clin. Invest. 114, 795–804 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Hendry, B.M. & Sharpe, C.C. Targeting Ras genes in kidney disease. Nephron 93, e129–e133 (2003).
  CAS PubMed Google Scholar
• Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362–365 (1993).
  Article CAS PubMed Google Scholar
• Okano, M., Bell, D.W., Haber, D.A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247–257 (1999).
  Article CAS PubMed Google Scholar
• Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).
  Article CAS PubMed Google Scholar
• Bottinger, E.P. & Bitzer, M. TGF-β signaling in renal disease. J. Am. Soc. Nephrol. 13, 2600–2610 (2002).
  Article PubMed Google Scholar
• Border, W.A. & Noble, N.A. Targeting TGF-β for treatment of disease. Nat. Med. 1, 1000–1001 (1995).
  Article CAS PubMed Google Scholar
• Strutz, F. et al. TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int. 59, 579–592 (2001).
  Article CAS PubMed Google Scholar
• Basile, D.P. et al. Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure. Am. J. Physiol. Renal Physiol. 288, F953–F963 (2005).
  Article CAS PubMed Google Scholar
• Forbes, J.M., Leaker, B., Hewitson, T.D., Becker, G.J. & Jones, C.L. Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Kidney Int. 55, 198–208 (1999).
  Article CAS PubMed Google Scholar
• Villanueva, S., Cespedes, C. & Vio, C.P. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R861–R870 (2006).
  Article CAS PubMed Google Scholar
• Ding, M. et al. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat. Med. 12, 1081–1087 (2006).
  Article CAS PubMed Google Scholar
• Rothenpieler, U.W. & Dressler, G.R. Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development. Development 119, 711–720 (1993).
  CAS PubMed Google Scholar
• Khwaja, A., Sharpe, C.C., Noor, M., Kloog, Y. & Hendry, B.M. The inhibition of human mesangial cell proliferation by _S_-trans, trans-farnesylthiosalicylic acid. Kidney Int. 68, 474–486 (2005).
  Article CAS PubMed Google Scholar
• Zaidi, N. et al. A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles. FEBS J. 274, 3138–3149 (2007).
  Article CAS PubMed Google Scholar
• Zeisberg, E.M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952–961 (2007).
  Article CAS PubMed Google Scholar
• Zeisberg, E.M., Potenta, S.E., Sugimoto, H., Zeisberg, M. & Kalluri, R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J. Am. Soc. Nephrol. 19, 2282–2287 (2008).
  Article PubMed PubMed Central Google Scholar
• Chatterjee, P.K. et al. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59, 2073–2083 (2001).
  Article CAS PubMed Google Scholar