KIF5B-RET fusions in lung adenocarcinoma (original) (raw)

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Acknowledgements

This work was supported in part by the program for promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NiBio), Grants-in-Aid from the Ministry of Health, Labour and Welfare for the 3rd-term Comprehensive 10-year Strategy for Cancer Control, the National Cancer Center Research and Development Fund and the Norwegian Cancer Society. National Cancer Center Biobank is supported by the National Cancer Center Research and Development Fund, Japan. We thank T. Urushidate, S. Ohashi, S. Mitani, K. Yokozawa, S. Wakai, C. Otsubo and H. Isomura of the National Cancer Center and D. Suzuki and K. Nagase of the National Center for Global Health and Medicine for technical assistance. We also thank J.D. Minna and L. Girard of the University of Texas Southwestern Medical Center, K. Kumamoto of Saitama Medical University and A. Okamoto of Jikei University for RET fusion screening, N. Morii of the National Institute of Advanced Industrial Science and Technology (AIST) for thermodynamic characterization of the KIF5B protein and M. Maekawa of the GSP laboratory for rapid preparation of the FISH probes.

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Author notes

  1. Takashi Kohno and Hitoshi Ichikawa: These authors equally contributed to this work.

Authors and Affiliations

  1. Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.,
    Takashi Kohno, Yoko Shimada & Hideaki Ogiwara
  2. Division of Genetics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.,
    Hitoshi Ichikawa, Hiromi Sakamoto & Teruhiko Yoshida
  3. Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.,
    Yasushi Totoki, Yasuhito Arai & Tatsuhiro Shibata
  4. Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.,
    Kazuki Yasuda, Masaki Hiramoto & Takao Nammo
  5. Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.,
    Koji Tsuta, Koh Furuta & Hitoshi Tsuda
  6. Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.,
    Reika Iwakawa, Takahiro Oike, Hirokazu Okayama & Jun Yokota
  7. Division of Refractory Cancer Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.,
    Masato Enari
  8. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Aaron J Schetter, Hirokazu Okayama & Curtis C Harris
  9. Department of Chemical and Biological Working Environment, Section of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Aage Haugen & Vidar Skaug
  10. Science Solutions Division, Mizuho Information and Research Institute, Chiyoda-ku, Tokyo, Japan.,
    Suenori Chiku
  11. Statistical Genetics Analysis Division, StaGen, Taito-ku, Tokyo, Japan.,
    Itaru Yamanaka
  12. Division of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.,
    Shun-ichi Watanabe
  13. Division of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.,
    Ikuo Sekine
  14. Cancer Genomics Project, University of Tokyo, Bunkyo-ku, Tokyo, Japan.,
    Seishi Ogawa

Authors

  1. Takashi Kohno
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  2. Hitoshi Ichikawa
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  3. Yasushi Totoki
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  4. Kazuki Yasuda
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  5. Masaki Hiramoto
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  6. Takao Nammo
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  7. Hiromi Sakamoto
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  8. Koji Tsuta
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  9. Koh Furuta
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  10. Yoko Shimada
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  11. Reika Iwakawa
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  12. Hideaki Ogiwara
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  13. Takahiro Oike
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  14. Masato Enari
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  15. Aaron J Schetter
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  16. Hirokazu Okayama
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  17. Aage Haugen
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  18. Vidar Skaug
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  19. Suenori Chiku
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  20. Itaru Yamanaka
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  21. Yasuhito Arai
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  22. Shun-ichi Watanabe
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  23. Ikuo Sekine
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  24. Seishi Ogawa
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  25. Curtis C Harris
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  26. Hitoshi Tsuda
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  27. Teruhiko Yoshida
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  28. Jun Yokota
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  29. Tatsuhiro Shibata
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Contributions

RNA sequencing: H.I., K.Y., M.H., T.N. and H.S. Sequence data processing: Y.T., S.C. and I.Y. Molecular biological analyses: T.K., Y.S., R.I., H. Ogiwara, T.O., M.E., A.J.S., H. Okayama, A.H., Y.A. and S.O. Clinical and pathological analyses: K.T., K.F., V.S., S.W., I.S. and H.T. Manuscript writing: T.K., H.I. and T.S. Study design: T.K., H.I., C.C.H., T.Y., J.Y. and T.S.

Corresponding author

Correspondence toTatsuhiro Shibata.

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The authors declare no competing financial interests.

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Kohno, T., Ichikawa, H., Totoki, Y. et al. KIF5B-RET fusions in lung adenocarcinoma.Nat Med 18, 375–377 (2012). https://doi.org/10.1038/nm.2644

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