Klotho-induced insulin resistance: a blessing in disguise? (original) (raw)

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• Published: 01 January 2006

Nature Medicine volume 12, pages 56–57 (2006)Cite this article

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Insulin resistance can be good for your health when it is caused by klotho, a hormone that prolongs life. A reduction in insulin-stimulated intracellular glucose availability may prevent intracellular lipid overload and lipotoxicity, a proposed mechanism of hte life-shortening metabolic syndrome.

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Figure 1: How Klotho and other liporegulatory factors influence cellular lipid homeostasis.

Simon Fenwick

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Authors and Affiliations

1. Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, 75390-8854, Texas, USA
   Roger H Unger

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1. Roger H Unger
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Unger, R. Klotho-induced insulin resistance: a blessing in disguise?.Nat Med 12, 56–57 (2006). https://doi.org/10.1038/nm0106-56

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• Issue Date: 01 January 2006
• DOI: https://doi.org/10.1038/nm0106-56

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