Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis (original) (raw)

References

1. Rodriguez, M., Oleszak, E. & Leibowitz, J. Theiler's murine encephalomyelitis: A model of demyelination and persistence of virus. Crit. Rev. Immunol. 7, 325–365 (1987).
   CAS PubMed Google Scholar
2. Fiette, L., Aubert, C., Brahic, M. & Rossi, C.P. Theiler's virus infection of β2-mi-croglobulin-deficient mice. J. Virol. 67, 589–592 (1993).
   CAS PubMed PubMed Central Google Scholar
3. Pullen, L.C., Miller, S.D., Dal Canto, M.C. & Kim, B.S. Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination. Eur. J. Immunol. 23, 2287–2293 (1993).
   Article CAS PubMed Google Scholar
4. Rodriguez, M., et al. Abrogation of resistance to Theiler's-induced demyelination in H–2b mice deficient in β2-microglobulin. J. Immunol. 151, 266–276 (1993).
   CAS PubMed Google Scholar
5. Njenga, M.K., et al. Theiler's virus persistence and demyelination in major histo-compatibility complex class II-deficient mice. J. Virol. 70, 1729–1737 (1996).
   CAS PubMed PubMed Central Google Scholar
6. Rodriguez, M., Leibowitz, J. & David, C.S. Susceptibility to Theiler's virus-induced demyelination: Mapping of the gene within the H–2D region. J. Exp. Med. 163, 620–631 (1986).
   Article CAS PubMed Google Scholar
7. Rodriguez, M. & David, C.S. Demyelination induced by Theiler's virus: Influence of the H–2 haplotype. J. Immunol. 135, 2145–2148 (1985).
   CAS PubMed Google Scholar
8. Foster, R.E., Whalen, C.C. & Waxman, S.G. Reorganization of the axon membrane in demyelinated peripheral nerve fibers: Morphological evidence. Science 210, 661–663 (1980).
   Article CAS PubMed Google Scholar
9. Bostock, H., Hall, S.M. & Smith, K.J. Demyelinated axons can form ‘nodes’ prior to remyelination.). Physiol. (Lond.) 308, 21P–23P (1980).
   Google Scholar
10. Smith, K.J., Bostock, H. & Hall, S.M. Saltatory conduction precedes remyelination in axons demyelinated with lysophosphatidyl choline. J. Neurol. Sci. 54, 13–31 (1982).
    Article CAS PubMed Google Scholar
11. Waxman, S.G. Demyelination in spinal cord injury and multiple sclerosis: What can we do to enhance functional recovery? J. Neurotrauma 9, S105–S117 (1992).
    PubMed Google Scholar
12. Rodriguez, M. & Sriram, S. Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody. J. Immunol. 140, 2950–2955 (1988).
    CAS PubMed Google Scholar
13. Miller, D.J., Rivera-Quiñones, C., Njenga, M.K., Leibowitz, J. & Rodriguez, M. Spontaneous CNS remyelination in p2 microglobulin-deficient mice following virus-induced demyelination. J. Neurosci. 15, 8345–8352 (1995).
    Article CAS PubMed PubMed Central Google Scholar
14. Miller, D.J., Njenga, M.K., Murray, P.D., Leibowitz, J. & Rodriguez, M. A monoclonal natural autoantibody that promotes remyelination suppresses central nervous system inflammation and increases virus expression after Theiler's virus-induced demyelination. Int. Immunol. 8, 131–141 (1996).
    Article CAS PubMed Google Scholar
15. Brinkmeier, H., Kaspar, A., Wietholter, H. & Rudel, R. Interleukin-2 inhibits sodium currents in human muscle cells. Pfluegers Arch. 420, 621–623 (19??).
16. Black, J.A., Felts, P., Smith, K.J., Kocksis, J.D. & Waxman, S.C. Distribution of sodium channels in chronically demyelinated spinal cord axons: Immuno-structural localization and electrophysiological observations. Brain Res. 544, 59–70 (1991).
    Article CAS PubMed Google Scholar
17. McDonald, W.I. & Sears, T.A. Effect of demyelination on conduction in the central nervous system. Brain 93, 583–598 (1970).
    Article CAS PubMed Google Scholar
18. Filippi, M., et al. Correlations between changes in disability and T2-weighted brain MRI activity in multiple sclerosis: A follow-up study. Neurology 45, 255–260 (1995).
    Article CAS PubMed Google Scholar
19. Gilbert, J.J. & Sadler, M. Unsuspected multiple sclerosis. Arch. Neurol. 40, 533–536 (1983).
    Article CAS PubMed Google Scholar
20. Mackay, R.P. & Hirano, A. Forms of benign multiple sclerosis: Report of two “clinically silent” cases discovered at autopsy. Arch. Neurol. 17, 588–600 (1967).
    Article CAS PubMed Google Scholar
21. Moll, C., Mourre, C., Lazdunsky, M. & Ulrich, J. Increase of sodium channels in demyelinated lesions of multiple sclerosis. Brain Res. 556, 311–316 (1991).
    Article CAS PubMed Google Scholar
22. Hauser, S.L., et al. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19, 578–587 (1986).
    Article CAS PubMed Google Scholar
23. Sibley, W.A., Bamford, C.R. & Clark, K. Clinical viral infections and multiple sclerosis. Lancet 1, 1313–1315 (1985).
    Article CAS PubMed Google Scholar
24. The IFNβ Multiple Sclerosis Group. Interferon beta-1 b is effective in relapsing-re-mitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double blind, placebo-controlled trial. Neurology 43, 655–661 (1993).
25. Iuliano, B.A., Schmelzer, J.D., Thiemann, R.L., Low, P.A. & Rodriguez, M. Motor and somatosensory-evoked potentials in mice infected with Theiler's murine encephalomyelitis virus. J. Neurol. Sci. 123, 186–194 (1994).
    Article CAS PubMed Google Scholar
26. Dugandzija-Novakovic, S., Koszowski, A.G., Levinson, S.R. & Shrager, P. Clustering of Na+ channels and node of Ranvier formation in remyelinating axons. J. Neurosci. 15, 492–503 (1995).
    Article CAS PubMed PubMed Central Google Scholar
27. Mourre, C., Widmann, C. & Lazdunski, M. Saxitoxin-sensitive Na+ channels: Presynaptic localization in cerebellum and hippocampus of neurological mutant mice. Brain Res. 533, 196–202 (1990).
    Article CAS PubMed Google Scholar
28. Robb, R.A., et al. ANALYZE: A comprehensive, operator-interactive software package for multidimensional medical image display and analysis. Comput. Med. Imag. Graphics 13, 433–454 (1989).
    Article CAS Google Scholar

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