Do-all receptor takes on coagulation, inflammation (original) (raw)

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• Published: 01 May 2005

Nature Medicine volume 11, pages 475–477 (2005)Cite this article

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How many critical functions can be jammed into one receptor? New work on thrombomodulin explores the limits. This already overtaxed protein binds HMGB1, a molecule that contributes to sepsis and other inflammatory conditions.

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Figure 1: Multitasking molecule.

Katherine Ris

References

1. Abeyama, K. et al. J. Clin. Invest. 115, 1267–1274 (2005).
   Article CAS PubMed PubMed Central Google Scholar
2. Esmon, C.T. J. Exp. Med 196, 561–564 (2002).
   Article CAS PubMed PubMed Central Google Scholar
3. Myles, T. et al. J. Biol. Chem. 278, 51059–51067 (2003).
   Article CAS PubMed Google Scholar
4. Esmon, C.T. J. Biol. Chem. 264, 4743–4746 (1989).
   CAS PubMed Google Scholar
5. Bernard, G.R. et al. N. Engl. J. Med. 344, 699–709 (2001).
   Article CAS PubMed Google Scholar
6. Tracey, K.J. Nature 420, 853–859 (2002).
   Article CAS PubMed Google Scholar
7. Busch, C., Cancilla, P., DeBault, L., Goldsmith, J. & Owen, W. Lab. Invest. 47, 498–504 (1982).
   CAS PubMed Google Scholar
8. Maruyama, I. & Majerus, P.W. Blood 69, 1481–1484 (1987).
   CAS PubMed Google Scholar
9. Conway, E.M. et al. J. Exp. Med. 196, 565–577 (2002).
   Article CAS PubMed PubMed Central Google Scholar

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1. Howard Hughes Medical Institute at the Oklahoma Medical Research Foundation, Oklahoma City, 73104, Oklahoma, USA
   Charles Esmon

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Esmon, C. Do-all receptor takes on coagulation, inflammation.Nat Med 11, 475–477 (2005). https://doi.org/10.1038/nm0505-475

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• Issue Date: 01 May 2005
• DOI: https://doi.org/10.1038/nm0505-475

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