Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator (original) (raw)
References
Cosby, K. et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat. Med.9, 1498–1505 (2003). ArticleCAS Google Scholar
Kinsella, J.P. & Abman, S.H. Inhaled nitric oxide: current and future uses in neonates. Semin. Perinatol.24, 387–395 (2000). ArticleCAS Google Scholar
Clark, R.H. et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N. Engl. J. Med.342, 469–474 (2000). ArticleCAS Google Scholar
Roberts, J.D., Jr. et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N. Engl. J. Med.336, 605–610 (1997). ArticleCAS Google Scholar
Doyle, M.P., Pickering, R.A., DeWeert, T.M., Hoekstra, J.W. & Pater, D. Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites. J. Biol. Chem.256, 12393–12398 (1981). CASPubMed Google Scholar
Nagababu, E., Ramasamy, S., Abernethy, D.R. & Rifkind, J.M. Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J. Biol. Chem.278, 46349–46356 (2003). ArticleCAS Google Scholar
Schreiber, M.D. et al. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N. Engl. J. Med.349, 2099–2107 (2003). ArticleCAS Google Scholar
Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group. N. Engl. J. Med.336, 597–604 (1997).
Martin, R.J. Nitric oxide for preemies—not so fast. N. Engl. J. Med.349, 2157–2149 (2003). ArticleCAS Google Scholar
Pierce, C.M., Peters, M.J., Cohen, G., Goldman, A.P. & Petros, A.J. Cost of nitric oxide is exorbitant. BMJ325, 336 (2002). ArticleCAS Google Scholar
Subhedar, N.V., Jauhari, P. & Natarajan, R. Cost of inhaled nitric oxide therapy in neonates. Lancet359, 1781–1782 (2002). Article Google Scholar
Kinsella, J.P., Griebel, J., Schmidt, J.M. & Abman, S.H. Use of inhaled nitric oxide during interhospital transport of newborns with hypoxemic respiratory failure. Pediatrics109, 158–161 (2002). Article Google Scholar
Gladwin, M.T. Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion. J. Clin. Invest.113, 19–21 (2004). ArticleCAS Google Scholar
Furchgott, R.F. & Bhadrakom, S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J. Pharmacol. Exp. Ther.108, 129–143 (1953). CASPubMed Google Scholar
Ignarro, L.J. et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J. Pharmacol. Exp. Ther.218, 739–749 (1981). CASPubMed Google Scholar
Kimura, H., Mittal, C.K. & Murad, F. Activation of guanylate cyclase from rat liver and other tissues by sodium azide. J. Biol. Chem.250, 8016–8022 (1975). CASPubMed Google Scholar
Lauer, T. et al. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc. Natl. Acad. Sci. USA98, 12814–12819 (2001). ArticleCAS Google Scholar
Pawloski, J.R. Hemoglobin and nitric oxide. N. Engl. J. Med.349, 402–5; author reply 402–405 (2003). Article Google Scholar
McMahon, T.J. Hemoglobin and nitric oxide. N. Engl. J. Med.349, 402–405; author reply 402–405 (2003). Article Google Scholar
Gladwin, M.T. et al. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc. Natl. Acad. Sci. USA97, 11482–11487 (2000). ArticleCAS Google Scholar
Zweier, J.L., Wang, P., Samouilov, A. & Kuppusamy, P. Enzyme-independent formation of nitric oxide in biological tissues. Nat. Med.1, 804–809 (1995). ArticleCAS Google Scholar
Hunter, C.J. et al. Cerebral blood flow and oxygenation during venoarterial and venovenous extracorporeal membrane oxygenation in the newborn lamb. Pediatr. Crit. Care. Med. in the press (2004).
Coates, A.L., Allen, P.D., MacNeish, C.F., Ho, S.L. & Lands, L.C. Effect of size and disease on estimated deposition of drugs administered using jet nebulization in children with cystic fibrosis. Chest119, 1123–1130 (2001). ArticleCAS Google Scholar
Clay, M.M., Pavia, D., Newman, S.P. & Clarke, S.W. Factors influencing the size distribution of aerosols from jet nebulisers. Thorax38, 755–759 (1983). ArticleCAS Google Scholar
Kinsella, J.P., Neish, S.R., Shaffer, E. & Abman, S.H. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet340, 819–820 (1992). ArticleCAS Google Scholar
Frostell, C., Fratacci, M.D., Wain, J.C., Jones, R. & Zapol, W.M. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation83, 2038–2047 (1991). ArticleCAS Google Scholar
Roberts, J.D., Jr. et al. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ. Res.72, 246–254 (1993). ArticleCAS Google Scholar
Gladwin, M.T. et al. S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. J. Biol. Chem.277, 27818–27828 (2002). ArticleCAS Google Scholar
Yang, B.K., Vivas, E.X., Reiter, C.D. & Gladwin, M.T. Methodologies for the sensitive and specific measurement of S-nitrosothiols, iron-nitrosyls, and nitrite in biological samples. Free Radic. Res.37, 1–10 (2003). ArticleCAS Google Scholar
Xu, X. et al. Measurements of nitric oxide on the heme iron and beta-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation. Proc. Natl. Acad. Sci. USA100, 11303–11308 (2003). ArticleCAS Google Scholar