Gene transfer through the blood–nerve barrier: NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis (original) (raw)

References

  1. Linington, C. et al. A permanent rat T Cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J. Immun. 133, 1946–1950 (1984).
    CAS PubMed Google Scholar
  2. Hartung, H.-P., StoII, G. & Toyka, K.V. Immune reactions in the peripheral nervous system. in Peripheral Neuropathy, 3rd edn (eds Dyck, P. J., Thomas, P.K., Griffin, J.W., Low, P.A. & Poduslo, J.F.) 418–462 (Saunders, Philadelphia, (1993).
    Google Scholar
  3. Izumo, S., Linington, C., Wekerle, H. & Meyermann, R. Morphologic study of experimental allergic neuritis mediated by T-Cell line specific for bovine P2 protein in Lewis rats. Lab. Invest. 53, 209–218 (1985).
    CAS PubMed Google Scholar
  4. Heininger, K., Stoll, G., Linington, C., Toyka, K.V. & Wekerle, H. Conduction failure and nerve conduction slowing in experimental autoimmune neuritis induced by P2-specific T Cell lines. Ann. Neural. 19, 44–49 (1986).
    Article CAS Google Scholar
  5. Kawaja, M.D., Rosenberg, M.B., Yoshida, K. & Gage, F.H., Cell transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of of their axons in adult rats. J. Neurosci. 12, 2849–2864 (1992).
    Article CAS Google Scholar
  6. Cournoyer, D. & Caskey, C.T. Gene therapy of the immune system. Annu. Rev. Immun. 11, 297–329 (1993).
    Article CAS Google Scholar
  7. Wekerle, H., Linington, C., Lassmann, H. & Meyermann, R. Cellular immune reactivity within the CNS. Trends Neurosci. 9, 271–277 (1986).
    Article Google Scholar
  8. Hwu, P. et al. Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-cDNA for the gene therapy of cancer in humans. J. Immun. 150, 4104–4115 (1993).
    CAS PubMed Google Scholar
  9. Lampert, P.W., Garret, R. & Powell, H.C. Demyelination in allergic and Marek's disease induced neuritis: Comparative electron microscopic studies. Acta Neuropath. 40, 103–110 (1977).
    Article CAS Google Scholar
  10. Heininger, K. et al. The role of macrophages in experimental autoimmune neuritis induced by a P2-specific T-Cell line. Ann. Neurol. 23, 326–331 (1988).
    Article CAS Google Scholar
  11. Sebert, M.E. & Shooter, E.M. Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury. J. Neurosci. Res. 36, 357–367 (1993).
    Article CAS Google Scholar
  12. Ehrhard, P.B., Ganter, U., Bauer, J. & Otten, U. Expression of functional trk protooncogene in human monocytes. Proc. natn. Acad. Sci. U.S.A. 90, 5423–5427 (1993).
    Article CAS Google Scholar
  13. Ehrhard, P.B., Erb, P., Graumann, U. & Otten, U. Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-Cell clones. Proc. natn. Acad. Sci. U.S.A. 90, 10984–10988 (1993).
    Article CAS Google Scholar
  14. Linington, C. et al. T Cell specific for the myelin oligodendrocyte glycoprotein (MOG) mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immun. 23, 1364–1372 (1993).
    Article CAS Google Scholar
  15. Scott, J. et al. Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature 302, 538–540 (1983).
    Article CAS Google Scholar
  16. Miller, D. & Rosman, G. Improved retroviral vectors for gene transfer and expression. Bio Technique 7, 980–990 (1989).
    CAS Google Scholar
  17. Markowitz, D., Goff, S. & Bank, A. A safe packaging line for gene transfer: Separating viral genes on two different plasmids. J. Virol. 62, 1120–1124 (1988).
    CAS PubMed PubMed Central Google Scholar
  18. Chen, C. & Okayama, H. High-efficiency transformation of mammalian Cells by plasmid DNA. Molec. Cell Biol. 7, 2745–2752 (1987).
    Article CAS Google Scholar
  19. Korsching, S. & Thoenen, H. Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: Correlation with density of sympathetic innervation. Proc. natn. Acad. Sci. U.S.A. 80, 3513–3516 (1983).
    Article CAS Google Scholar
  20. Spranger, M. et al. Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: Comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo. Eur. J. Neurosci. 2, 69–76 (1990).
    Article Google Scholar
  21. Castrén, E., Zafra, F., Thoenen, H. & Lindholm, D. Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex. Proc. natn. Acad. Sci. U.S.A. 89, 9444–9448 (1992).
    Article Google Scholar
  22. Gehrmann, J. et al. Spinal cord microglia in experimental allergic neuritis: Evidence for fast and remote activation. Lab. Invest. 67, 100–113 (1992).
    CAS PubMed Google Scholar

Download references