Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques (original) (raw)

References

  1. Bangham, C.R.M. & McMichael, A.J. in T Cells (eds Feldmann, M., Lamb, J. & Owen, M. J.) 281–310 (Wiley, New York, 1989).
    Google Scholar
  2. Lukacher, A.E., Braciale, V.L. & Braciale, T.J. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J exp. Med. 160, 814–826 (1984).
    Article CAS Google Scholar
  3. McMichael, A.J. & Walker, B. Cytotoxic T lymphocyte epitopes: Implications for HIV vaccines. AIDS (suppl.) 8, S155–S173 (1994).
    Google Scholar
  4. Koup, R. et al. Temporal association of cellular immune responses with the initial control of viraemia in primary human immunodeficiency virus type 1 syndrome. J. virol. 68, 4650–4655 (1994).
    CAS PubMed PubMed Central Google Scholar
  5. Walker, C.M., Moody, D.J., Stites, D.P. & Levy, J.A. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234, 1563–1566 (1986).
    Article CAS Google Scholar
  6. Tsubota, H.C., Lord, C.I., Watkins, D.I., Morimoto, C. & Letvin, N.L. A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes. J. exp. Med. 169, 1421–1434 (1989).
    Article CAS Google Scholar
  7. Mackewicz, C.E., Ortega, H.W. & Levy, J.A. CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual. J. clin. Invest. 87, 1462–1466 (1991).
    Article CAS Google Scholar
  8. Kannagi, M., Chalifoux, L.V., Lord, C.I. & Letvin, N.L. Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes. J. Immun. 140, 2237–2242 (1988).
    CAS PubMed Google Scholar
  9. Rowland-Jones, S. et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nature Med. 1, 59–64 (1995).
    Article Google Scholar
  10. Chakrabarti, L. et al. Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature 328, 543–547 (1987).
    Article CAS Google Scholar
  11. Letvin, N. et al. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science 230, 71–73 (1985).
    Article CAS Google Scholar
  12. Kestler, H. et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651–662 (1991).
    Article CAS Google Scholar
  13. Rud, E. et al. Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants. J. Gen. Viral. 75, 529–543 (1994).
    Article CAS Google Scholar
  14. Rud, E. et al. Infectious molecular clones of SIVmac32H: Nef deletion controls ability to re-isolate virus from rhesus macaques. Vaccines 92: Modem Approaches to New Vaccines including AIDS (eds F. Brown, R.M. Chanock, H.S. Ginsberg, and R.A. Lerner) 239–245 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1992).
    Google Scholar
  15. Daniel, M.D., Kirchhoff, F., Czajak, S.C., Sehgal, P.K. & Desrosiers, R.C. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938–1941 (1992).
    Article CAS Google Scholar
  16. Robert-Guroff, M. et al. Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages. J. Viral. 64, 3391–3398 (1990).
    CAS Google Scholar
  17. Bachmann, M.-F. et al. Induction of protective cytotoxic T cells with viral proteins. Eur. J. Immun. 24, 2228–2236 (1994).
    Article CAS Google Scholar
  18. Cao, Y., Qin, L., Zhang, L., Safrit, J. & Ho, D. Virologic and immunologic characterisation of long-term survivors of human immunodeficiency virus type 1 infection. New Engl. J. Med. 332, 201–208 (1995).
    Article CAS Google Scholar
  19. Pantaleo, G. et al. Studies in subjects with Long-term nonprogressive human immunodeficiency virus infection. New Eng. J. Med. 332, 209–216 (1995).
    Article CAS Google Scholar
  20. Ariyoshi, K. et al. HIV-2-specific cytoxic T-lymphocyte activity is inversely related to proviral load. AIDS 9, 555–559 (1995).
    Article CAS Google Scholar
  21. Yasutomi, Y., Reimann, K.A., Lord, C.I., Miller, M.D. & Letvin, N.L. Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys. J. Virol. 67, 1707–1711 (1993).
    CAS PubMed PubMed Central Google Scholar
  22. Brinchmann, J.E., Gaudernack, G. & Vartdal, F. CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells: Evidence for a soluble inhibitor. J. Immun. 144, 2961–2966 (1990).
    CAS PubMed Google Scholar
  23. Gotch, P.M., Nixon, D.F., Alp, N., McMichael, A.J. & Borysiewicz, L.K. High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals. Int. Immun. 2, 707–712 (1990).
    Article CAS Google Scholar
  24. Abimuku, A.G. et al. HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques. Nature Med. 1, 321–329 (1995).
    Article Google Scholar
  25. Culmann, B., Gomard, E. & Kieny, M.-P. Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 nef protein. J. Immun. 146, 1560–1565 (1991).
    CAS PubMed Google Scholar
  26. Culmann-Penciolelli, B. et al. Identification of multirestricted immunodominant regions recognised by cytolytic T lymphocytes in the human immunodeficiency virus type 1 nef protein. J. Virol. 68, 7336–7343 (1994).
    CAS PubMed PubMed Central Google Scholar
  27. Bourgault, I. et al. Simian immunodeficiency virus as a model for vaccination against HIV. J. Immun. 152, 2530–2537 (1994).
    CAS PubMed Google Scholar
  28. Lamhamedi-Cherradi, S.C. et al. Qualitative and quantitative analysis of human cytotoxic T lymphocyte responses to HIV-1 proteins. AIDS 6, 1249–1258 (1992).
    Article CAS Google Scholar
  29. Nowak, M.A. et al. Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature (in the press).
  30. Rowland-Jones, S. & McMichael, A.J. Cell-mediated immune responses in HIV-exposed individuals: Have they cleared the virus? Curr. Topics Immun. (in the press).
  31. Gotch, F., Hovell, R., Delchambre, M., Silvera, P. & McMichael, M., T-cell responses to simian immunodeficiency virus by cynomolgus macaque monkeys immunized with recombinant vaccinia virus. AIDS 5, 317–320 (1991).
    Article CAS Google Scholar
  32. Townsend, A. et al. Defective presentation to class 1 restricted cytotoxic T lymphocytes in vaccinia infected cells is overcome by enhanced degradation of antigen. J. exp. Med. 168, 1211–1224 (1988).
    Article CAS Google Scholar
  33. Norusis, M.J. SPSS/PC+ V2.0 (SPSS Inc., Chicago, Illinois, 1988).
    Google Scholar
  34. Lefkovits, I. & Waldmann, H. Limiting dilution analysis of cells in the immune system (Cambridge University Press, Cambridge, 1979).
    Google Scholar
  35. Rose, J., Silvera, P., Flanagan, B., Kitchin, P. & Almond, N. The development of PCR-based assays for the detection and differentiation of simian immunodeficiency virus in vivo. J. Virol. Methods 51, 229–239 (1995).
    Article CAS Google Scholar
  36. Bootman, J. & Kitchin, P. An international collaborative study to assess a set of reference reagents for HIV-1 PCR. J. Virol. Methods 37, 23–42 (1992).
    Article CAS Google Scholar
  37. Sambrook, J., Fritsch, E. & Maniatis, T. Molecular Cloning: A Laboratory Manual, 2nd edn (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1989).
    Google Scholar
  38. Saluz, H. & Jost, J.A. A simple high-resolution procedure to study DNA methylation and in vivo DNA-protein interactions on a single copy gene level in higher eukaryotes. Proc. natn. Acad. Sci. U.S.A. 86, 2602–2626 (1989).
    Article CAS Google Scholar
  39. An, S., Franklin, D. & Fleming, K. Generation of dioxygenin-labelled double-stranded probes using the polymerase chain reaction. Molec. Cell Probes 6, 193–200 (1992).
    Article CAS Google Scholar
  40. Bootman, J.S. & Kitchen, P.A. Reference preparations in the standardisation of HIV. l PCR: An international collaborative study. J. Virol. Methods 49, 1–8 (1994).
    Article CAS Google Scholar

Download references