A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth (original) (raw)

• Folkman, J. Addressing tumor blood vessels. Nature Biotechnol. 15, 510 (1997).
• Folkman, J. Angiogenesis and angiogenesis inhibition: An overview. EXS 79, 1–8 (1997).
  CAS PubMed Google Scholar
• Folkman, J. Antiangiogenic gene therapy. Proc. Natl. Acad. Sci. USA 95, 9064–9066 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• O'Reilly, M.S., Holmgren, L., Chen, C. & Folkman, J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Med. 2, 689–692 (1996).
  Article CAS PubMed Google Scholar
• O'Reilly, M.S. et al. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 88, 277–285 (1997).
  Article CAS PubMed Google Scholar
• Augustin, H.G. Antiangiogenic tumor therapy: Will it work? Trends Pharmacol. Sci. 19, 216–222 (1998).
  Article CAS PubMed Google Scholar
• Eberhard, A. et al. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res. 60, 1388–1393 (2000).
  CAS PubMed Google Scholar
• Folkman, J. Tumor angiogenesis and tissue factor. Nature Med. 2, 167–168 (1996).
  Article CAS PubMed Google Scholar
• Goede, V. et al. Prognostic value of angiogenesis in mammary tumors. Anticancer Res. 18, 2199–2202 (1998).
  CAS PubMed Google Scholar
• Folkman, J. Can mosaic tumor vessels facilitate molecular diagnosis of cancer? Proc. Natl. Acad. Sci. USA 98, 398–400 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Heidenreich, R., Kappel, A. & Breier, G. Tumor endothelium-specific transgene expression directed by vascular endothelial growth factor receptor-2 (FLK-1) promoter/enhancer sequences. Cancer Res. 60, 6142–6147 (2000).
  CAS PubMed Google Scholar
• Hicklin, D.J., Marincola, F.M. & Ferrone, S. HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story. Mol. Med. Today 5, 178–186 (1999).
  Article CAS PubMed Google Scholar
• Ruiter, D.J., Mattijssen, V., Broecker, E.B. & Ferrone, S. MHC antigens in human melanomas. Semin. Cancer Biol. 2, 35–45 (1991).
  CAS PubMed Google Scholar
• Cheng, W.F. et al. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J. Clin. Invest. 108, 669–678 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Wei, Y.Q. et al. Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nature Med. 6, 1160–1166 (2000).
  Article CAS PubMed Google Scholar
• Kisker, O. et al. Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model. Cancer Res. 61, 7669–7674 (2001).
  CAS PubMed Google Scholar
• Cross, M.J. & Claesson-Welsh, L. FGF and VEGF function in angiogenesis: signaling pathways, biological responses and therapeutic inhibition. Trends Pharmacol. Sci. 22, 201–207 (2001).
  Article CAS PubMed Google Scholar
• Dias, S. et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J. Clin. Invest. 106, 511–521 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Drake, C.J., LaRue, A., Ferrara, N. & Little, C.D. VEGF regulates cell behavior during vasculogenesis. Dev. Biol. 224, 178–188 (2000).
  Article CAS PubMed Google Scholar
• Ferrara, N. VEGF: An update on biological and therapeutic aspects. Curr. Opin. Biotechnol. 11, 617–624 (2000).
  Article CAS PubMed Google Scholar
• Folkman, J. & D'Amore, P.A. Blood vessel formation: what is its molecular basis? Cell 87, 1153–1155 (1996).
  Article CAS PubMed Google Scholar
• McMahon, G. VEGF receptor signaling in tumor angiogenesis. Oncologist 5 Suppl 1, 3–10 (2000).
  Article CAS PubMed Google Scholar
• Ortega, N., Hutchings, H. & Plouet, J. Signal relays in the VEGF system. Front Biosci. 4, D141–D152 (1999).
  CAS PubMed Google Scholar
• Strawn, L.M. et al. FLK-1 as a target for tumor growth inhibition. Cancer Res. 56, 3540–3545 (1996).
  CAS PubMed Google Scholar
• Taraboletti, G. & Margosio, B. Antiangiogenic and antivascular therapy for cancer. Curr. Opin. Pharmacol. 1, 378–384 (2001).
  Article CAS PubMed Google Scholar
• Ochsenbein, A.F. et al. Roles of tumor localization, second signals and cross priming in cytotoxic T-cell induction. Nature 411, 1058–1064 (2001).
  Article CAS PubMed Google Scholar
• Hata, Y., Rook, S.L. & Aiello, L.P. Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathway. Diabetes 48, 1145–1155 (1999).
  Article CAS PubMed Google Scholar
• St Croix, B. et al. Genes expressed in human tumor endothelium. Science 289, 1197–1202 (2000).
  Article CAS PubMed Google Scholar
• Niethammer, A.G. et al. An oral DNA vaccine against human carcinoembryonic antigen (CEA) prevents growth and dissemination of Lewis lung carcinoma in CEA transgenic mice. Vaccine 20, 421–429 (2001).
  Article CAS PubMed Google Scholar
• Niethammer, A.G. et al. Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma. Cancer Res. 61, 6178–6184 (2001).
  CAS PubMed Google Scholar
• Darji, A. et al. Oral somatic transgene vaccination using attenuated S. typhimurium. Cell 91, 765–775 (1997).
  Article CAS PubMed Google Scholar
• Lode, H.N. et al. Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma. Proc. Natl. Acad. Sci. USA 95, 2475–2480 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Schrama, D. et al. Targeting of lymphotoxin-α to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue. Immunity 14, 111–121 (2001).
  Article CAS PubMed Google Scholar
• Kaesler, S., Regenbogen, J., Durka, S., Goppelt, A. & Werner, S. The healing skin wound: A novel site of action of the chemokine c10. Cytokine 17, 157–163 (2002).
  Article CAS PubMed Google Scholar
• Werner, S. et al. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc. Natl. Acad. Sci. USA 89, 6896–6900 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Barlow, C. et al. Atm-deficient mice: A paradigm of ataxia telangiectasia. Cell 86, 159–171 (1996).
  Article CAS PubMed Google Scholar
• Paylor, R. et al. Alpha7 nicotinic receptor subunits are not necessary for hippocampal- dependent learning or sensorimotor gating: A behavioral characterization of Acra7-deficient mice. Learn. Mem. 5, 302–316 (1998).
  Article CAS PubMed PubMed Central Google Scholar