Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice (original) (raw)
The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis132, 182–5. (1985).
Shapiro, S.D. Vascular atrophy and VEGFR-2 signaling: old theories of pulmonary emphysema meet new data. J. Clin. Invest.106, 1309–1310 (2000). ArticleCAS Google Scholar
Kasahara, Y. et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest.106, 1311–1319 (2000). ArticleCAS Google Scholar
Tuder, R.M., Petrache, I., Elias, J.A., Voelkel, N.F. & Henson, P.M. Apoptosis and emphysema: the missing link. Am. J. Respir. Cell Mol. Biol.28, 551–554 (2003). ArticleCAS Google Scholar
Tuder, R.M. et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am. J. Respir. Cell Mol. Biol.29, 88–97 (2003). ArticleCAS Google Scholar
Rangasamy, T. et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest.114, 1248–1259 (2004). ArticleCAS Google Scholar
Hannun, Y.A. & Obeid, L.M. The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem.277, 25847–25850 (2002). ArticleCAS Google Scholar
Reunanen, N. et al. Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. J. Biol. Chem.273, 5137–5145 (1998). ArticleCAS Google Scholar
Hannun, Y.A. & Luberto, C. Ceramide in the eukaryotic stress response. Trends Cell Biol.10, 73–80 (2000). ArticleCAS Google Scholar
Kolesnick, R. & Fuks, Z. Radiation and ceramide-induced apoptosis. Oncogene22, 5897–5906 (2003). ArticleCAS Google Scholar
Luberto, C., Kraveka, J.M. & Hannun, Y.A. Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology. Neurochem. Res.27, 609–617 (2002). ArticleCAS Google Scholar
Zhang, Y. et al. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell89, 63–72 (1997). ArticleCAS Google Scholar
Chalfant, C.E. et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J. Biol. Chem.277, 12587–12595 (2002). ArticleCAS Google Scholar
Heinrich, M. et al. Ceramide as an activator lipid of cathepsin D. Adv. Exp. Med. Biol.477, 305–315 (2000). ArticleCAS Google Scholar
Gulbins, E. & Grassme, H. Ceramide and cell death receptor clustering. Biochim. Biophys. Acta1585, 139–145 (2002). ArticleCAS Google Scholar
Siskind, L.J., Kolesnick, R.N. & Colombini, M. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J. Biol. Chem.277, 26796–26803 (2002). ArticleCAS Google Scholar
Goggel, R. et al. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat. Med.10, 155–160 (2004). Article Google Scholar
Cuvillier, O. et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature381, 800–803 (1996). ArticleCAS Google Scholar
Payne, S.G., Milstien, S. & Spiegel, S. Sphingosine-1-phosphate: dual messenger functions. FEBS Lett.531, 54–57 (2002). ArticleCAS Google Scholar
Morita, Y. & Tilly, J.L. Sphingolipid regulation of female gonadal cell apoptosis. Ann. NY Acad. Sci.905, 209–220 (2000). ArticleCAS Google Scholar
Kasahara, Y. et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am. J. Respir. Crit. Care Med.163, 737–744 (2001). ArticleCAS Google Scholar
Norred, W.P., Voss, K.A., Riley, R.T. & Plattner, R.D. Fumonisin toxicity and metabolism studies at the USDA. Fumonisin toxicity and metabolism. Adv. Exp. Med. Biol.392, 225–236 (1996). ArticleCAS Google Scholar
Peng, X. et al. Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am. J. Respir. Crit. Care Med.169, 1245–1251 (2004). Article Google Scholar
Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science296, 346–349 (2002). ArticleCAS Google Scholar
Ravid, T. et al. Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells. Am. J. Physiol. Lung Cell Mol. Physiol.284, L1082–L1092 (2003). ArticleCAS Google Scholar
Hautamaki, R.D., Kobayashi, D.K., Senior, R.M. & Shapiro, S.D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science277, 2002–2004 (1997). ArticleCAS Google Scholar
Ogretmen, B. et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J. Biol. Chem.277, 12960–12969 (2002). ArticleCAS Google Scholar
Petrache, I. et al. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. FASEB J.17, 407–416 (2003). ArticleCAS Google Scholar
Soler, N. et al. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur. Respir. J.14, 1015–1022 (1999). ArticleCAS Google Scholar
Slowik, M.R., De Luca, L.G., Min, W. & Pober, J.S. Ceramide is not a signal for tumor necrosis factor-induced gene expression but does cause programmed cell death in human vascular endothelial cells. Circ. Res.79, 736–747 (1996). ArticleCAS Google Scholar
Kroesen, B.J. et al. BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J. Biol. Chem.278, 14723–14731 (2003). ArticleCAS Google Scholar
Haimovitz-Friedman, A. et al. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med.186, 1831–1841 (1997). ArticleCAS Google Scholar
Taraseviciene-Stewart, L. et al. An animal model of autoimmune emphysema. Am. J. Respir. Crit. Care Med.171, 734–742 (2005). Article Google Scholar
Pfeiffer, A. et al. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur. J. Immunol.31, 3153–3164 (2001). ArticleCAS Google Scholar
Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J. Clin. Invest.110, 3–8 (2002). ArticleCAS Google Scholar
Chavakis, E. & Dimmeler, S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler. Thromb. Vasc. Biol.22, 887–893 (2002). ArticleCAS Google Scholar
Pautz, A. et al. Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells. Kidney Int.61, 790–796 (2002). ArticleCAS Google Scholar
Lavrentiadou, S.N. et al. Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione. Am. J. Respir. Cell Mol. Biol.25, 676–684 (2001). ArticleCAS Google Scholar
Horinouchi, K. et al. Acid sphingomyelinase deficient mice: a model of types A and B Niemann- Pick disease. Nat. Genet.10, 288–293 (1995). ArticleCAS Google Scholar
Otterbach, B. & Stoffel, W. Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease). Cell81, 1053–1061 (1995). ArticleCAS Google Scholar
Ikegami, M., Dhami, R. & Schuchman, E.H. Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease. Am. J. Physiol. Lung Cell Mol. Physiol.284, L518–L525 (2003). ArticleCAS Google Scholar
Fletcher, C. & Peto, R. The natural history of chronic airflow obstruction. Br. Med. J.1, 1645–1648 (1977). ArticleCAS Google Scholar
Tilly, J.L. & Kolesnick, R.N. Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility. Biochim. Biophys. Acta1585, 135–138 (2002). ArticleCAS Google Scholar
Tuder, R.M., Wood, K., Taraseviciene, L., Flores, S.C. & Voekel, N.F. Cigarette smoke extract decreases the expression of vascular endothelial growth factor by cultured cells and triggers apoptosis of pulmonary endothelial cells. Chest117, 241S–242S (2000). ArticleCAS Google Scholar
Bligh, E.G. & Dyer, W.J. A rapid method of total lipid extraction and purification. Can. J. Med. Sci.37, 911–917 (1959). CAS Google Scholar
Dobrowsky, R.T. & Kolesnick, R.N. Analysis of sphingomyelin and ceramide levels and the enzymes regulating their metabolism in response to cell stress. Methods Cell Biol.66, 135–165 (2001). ArticleCAS Google Scholar
Perry, D.K., Bielawska, A. & Hannun, Y.A. Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol.312, 22–31 (2000). ArticleCAS Google Scholar
Tepper, A.D. & Van Blitterswijk, W.J. Ceramide mass analysis by normal-phase high-performance liquid chromatography. Methods Enzymol.312, 16–22 (2000). ArticleCAS Google Scholar
Sullards, M.C. & Merrill, A.H., Jr. Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Sci STKE2001, PL1 (2001). CASPubMed Google Scholar
Berdyshev, E.V., Gorshkova, I.A., Garcia, J.G.N., Natarajan, V. & Hubbard, W.C. Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal. Biochem.339, 129–136 (2005). ArticleCAS Google Scholar