Inflammatory arthritis requires Foxo3a to prevent Fas ligand–induced neutrophil apoptosis (original) (raw)

References

1. Firestein, G.S. & Zvaifler, N.J. How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end. Arthritis Rheum. 46, 298–308 (2002).
   Article CAS Google Scholar
2. Wipke, B.T. & Allen, P.M. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J. Immunol. 167, 1601–1608 (2001).
   Article CAS Google Scholar
3. Lee, D.M. & Weinblatt, M.E. Rheumatoid arthritis. Lancet 358, 903–911 (2001).
   Article CAS Google Scholar
4. Birkenkamp, K.U. & Coffer, P.J. FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J. Immunol. 171, 1623–1629 (2003).
   Article CAS Google Scholar
5. Medema, R.H., Kops, G.J., Bos, J.L. & Burgering, B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404, 782–787 (2000).
   Article CAS Google Scholar
6. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857–868 (1999).
   Article CAS Google Scholar
7. Dijkers, P.F. et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156, 531–542 (2002).
   Article CAS Google Scholar
8. Stahl, M. et al. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J. Immunol. 168, 5024–5031 (2002).
   Article CAS Google Scholar
9. Asselin-Labat, M.L. et al. GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin 2 withdrawal-induced apoptosis. Blood 104, 215–223 (2004).
   Article CAS Google Scholar
10. Lin, L., Hron, J.D. & Peng, S.L. Regulation of NF-κB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21, 203–213 (2004).
    Article CAS Google Scholar
11. Crossley, L.J. Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1. J. Leukoc. Biol. 74, 583–592 (2003).
    Article CAS Google Scholar
12. Yang, K.Y. et al. Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cell. Signal. 15, 225–233 (2003).
    Article CAS Google Scholar
13. Kouskoff, V. et al. Organ-specific disease provoked by systemic autoimmunity. Cell 87, 811–822 (1996).
    Article CAS Google Scholar
14. Ji, H. et al. Critical roles for interleukin 1 and tumor necrosis factor α in antibody-induced arthritis. J. Exp. Med. 196, 77–85 (2002).
    Article CAS Google Scholar
15. Matsumoto, I. et al. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat. Immunol. 3, 360–365 (2002).
    Article CAS Google Scholar
16. Lee, D.M. et al. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297, 1689–1692 (2002).
    Article CAS Google Scholar
17. Ji, H. et al. Arthritis critically dependent on innate immune system players. Immunity 16, 157–168 (2002).
    Article CAS Google Scholar
18. Matsumoto, I., Staub, A., Benoist, C. & Mathis, D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286, 1732–1735 (1999).
    Article CAS Google Scholar
19. Mayadas, T.N., Johnson, R.C., Rayburn, H., Hynes, R.O. & Wagner, D.D. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74, 541–554 (1993).
    Article CAS Google Scholar
20. Collart, M.A., Belin, D., Vassalli, J.D., de Kossodo, S. & Vassalli, P. a interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 164, 2113–2118 (1986).
    Article CAS Google Scholar
21. Li, P. et al. AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Mol. Cell. Biol. 23, 104–118 (2003).
    Article Google Scholar
22. Alvarez, B., Martinez-Alvarez, C., Burgering, B.M.T. & Carrera, A.C. Forkhead transcription factors contribute to execution of the mitotic programme in mammals. Nature 413, 744–747 (2001).
    Article CAS Google Scholar
23. Alvarado-Kristensson, M. et al. p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J. Exp. Med. 199, 449–458 (2004).
    Article CAS Google Scholar
24. Altznauer, F. et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J. Exp. Med. 199, 1343–1354 (2004).
    Article CAS Google Scholar
25. Norris, J.S. et al. The use of Fas Ligand, TRAIL and Bax in gene therapy of prostate cancer. Curr. Gene Ther. 1, 123–136 (2001).
    Article CAS Google Scholar
26. Villunger, A., O'Reilly, L.A., Holler, N., Adams, J. & Strasser, A. Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. J. Exp. Med. 192, 647–658 (2000).
    Article CAS Google Scholar
27. Gerth, A.J., Pham, C.T.N. & Peng, S.L. Nuclear factor of activated T cells regulates the symmetry and intensity of immune complex-mediated synovitis. Arthritis Rheum. 50, 3392–3395 (2004).
    Article CAS Google Scholar
28. Luo, Y. & Dorf, M.E. Unit 3.20. Isolation of Mouse Neutrophils. in Current Protocols in Immunology (eds. Coligan, J.E., Margulies, D.H., Shevach, E.M. & Strober, W.) (John Wiley & Sons, Inc., Philadelphia, 1997).
    Google Scholar
29. Gerth, A.J., Lin, L. & Peng, S.L. T-bet regulates T-independent IgG2a class switching. Int. Immunol. 15, 937–944 (2003).
    Article CAS Google Scholar
30. Wang, X. & Seed, B.A. PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res. 31, e154 (2003).
    Article Google Scholar

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