Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo (original) (raw)

• Risau, W. Mechanisms of angiogenesis. Nature 386, 671–674 (1997).
  Article CAS Google Scholar
• Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27–31 (1995).
  Article CAS Google Scholar
• Carmeliet, P. Angiogenesis in health and disease. Nat. Med. 9, 653–660 (2003).
  Article CAS Google Scholar
• Jiang, B.H., Zheng, J.Z., Aoki, M. & Vogt, P.K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA 97, 1749–1753 (2000).
  Article CAS Google Scholar
• Kandel, E.S. & Hay, N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210–229 (1999).
  Article CAS Google Scholar
• Chen, W.S. et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203–2208 (2001).
  Article CAS Google Scholar
• Peng, X.D. et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 17, 1352–1365 (2003).
  Article CAS Google Scholar
• O'neill, B.T. & Abel, E.D. Akt1 in the cardiovascular system: friend or foe? J. Clin. Invest. 115, 2059–2064 (2005).
  Article CAS Google Scholar
• Shiojima, I. et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115, 2108–2118 (2005).
  Article CAS Google Scholar
• Byzova, T.V. et al. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol. Cell 6, 851–860 (2000).
  CAS PubMed Google Scholar
• Ruoslahti, E. & Engvall, E. Integrins and vascular extracellular matrix assembly. J. Clin. Invest. 99, 1149–1152 (1997).
  Article CAS Google Scholar
• Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7, 575–583 (2001).
  Article CAS Google Scholar
• Byzova, T.V. et al. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Blood 99, 4434–4442 (2002).
  Article CAS Google Scholar
• Tammela, T., Enholm, B., Alitalo, K. & Paavonen, K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 65, 550–563 (2005).
  Article CAS Google Scholar
• Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511–2514 (1999).
  Article CAS Google Scholar
• Agah, A., Kyriakides, T.R., Lawler, J. & Bornstein, P. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am. J. Pathol. 161, 831–839 (2002).
  Article CAS Google Scholar
• Bornstein, P. Thrombospondins as matricellular modulators of cell function. J. Clin. Invest. 107, 929–934 (2001).
  Article CAS Google Scholar
• Chen, J. et al. Impaired platelet responses to thrombin and collagen in AKT-1 deficient mice. Blood 104, 1703–1710 (2004).
  Article CAS Google Scholar
• Ackah, E. et al. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Invest. 115, 2119–2127 (2005).
  Article CAS Google Scholar
• Mazure, N.M., Chen, E.Y., Laderoute, K.R. & Giaccia, A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90, 3322–3331 (1997).
  CAS PubMed Google Scholar
• Arsham, A.M., Plas, D.R., Thompson, C.B. & Simon, M.C. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 64, 3500–3507 (2004).
  Article CAS Google Scholar
• Yu, J. et al. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc. Natl. Acad. Sci. USA 102, 10999–11004 (2005).
  Article CAS Google Scholar
• van Hinsbergh, V.W., Collen, A. & Koolwijk, P. Role of fibrin matrix in angiogenesis. Ann. NY Acad. Sci. 936, 426–437 (2001).
  Article CAS Google Scholar
• Aicher, A. et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat. Med. 9, 1370–1376 (2003).
  Article CAS Google Scholar
• Hotary, K.B. et al. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 114, 33–45 (2003).
  Article CAS Google Scholar
• Puolakkainen, P.A., Brekken, R.A., Muneer, S. & Sage, E.H. Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol. Cancer Res. 2, 215–224 (2004).
  CAS PubMed Google Scholar
• Visse, R. & Nagase, H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 92, 827–839 (2003).
  Article CAS Google Scholar
• Simantov, R. & Silverstein, R.L. CD36: a critical anti-angiogenic receptor. Front. Biosci. 8, s874–s882 (2003).
  Article CAS Google Scholar
• Rodriguez-Manzaneque, J.C. et al. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc. Natl. Acad. Sci. USA 98, 12485–12490 (2001).
  Article CAS Google Scholar
• Armstrong, L.C. et al. Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. Mol. Biol. Cell 13, 1893–1905 (2002).
  Article CAS Google Scholar
• Lange-Asschenfeldt, B. et al. Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2–deficient mice. Blood 99, 538–545 (2002).
  Article CAS Google Scholar
• Bornstein, P., Agah, A. & Kyriakides, T.R. The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury. Int. J. Biochem. Cell Biol. 36, 1115–1125 (2004).
  Article CAS Google Scholar
• Shiojima, I. & Walsh, K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 90, 1243–1250 (2002).
  Article CAS Google Scholar
• Sun, J.F. et al. Microvascular patterning is controlled by fine-tuning the Akt signal. Proc. Natl. Acad. Sci. USA 102, 128–133 (2005).
  Article CAS Google Scholar
• Nagoshi, T. et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J. Clin. Invest. 115, 2128–2138 (2005).
  Article CAS Google Scholar
• Reynolds, L.E. et al. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat. Med. 8, 27–34 (2002).
  Article CAS Google Scholar
• Dong, Q.G. et al. A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Arterioscler. Thromb. Vasc. Biol. 17, 1599–1604 (1997).
  Article CAS Google Scholar
• Byzova, T.V., Kim, W., Midura, R.J. & Plow, E.F. Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein. Exp. Cell Res. 254, 299–308 (2000).
  Article CAS Google Scholar
• De, S. et al. Molecular pathway for cancer metastasis to bone. J. Biol. Chem. 278, 39044–39050 (2003).
  Article CAS Google Scholar
• Narizhneva, N.V. et al. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 19, 1158–1160 (2005).
  Article CAS Google Scholar
• De, S. et al. VEGF-integrin interplay controls tumor growth and vascularization. Proc. Natl. Acad. Sci. USA 102, 7589–7594 (2005).
  Article CAS Google Scholar
• Takahashi, T. et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. 5, 434–438 (1999).
  Article CAS Google Scholar
• Han, E.D., MacFarlane, R.C., Mulligan, A.N., Scafidi, J. & Davis, A.E., III. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J. Clin. Invest. 109, 1057–1063 (2002).
  Article CAS Google Scholar
• Stockton, R.A., Schaefer, E. & Schwartz, M.A. p21-activated kinase regulates endothelial permeability through modulation of contractility. J. Biol. Chem. 279, 46621–46630 (2004).
  Article CAS Google Scholar
• Soula-Rothhut, M. et al. The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells. Exp. Cell Res. 304, 187–201 (2005).
  Article CAS Google Scholar