A novel dendritic cell subset involved in tumor immunosurveillance (original) (raw)

Nature Medicine volume 12, pages 214–219 (2006)Cite this article

Abstract

The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C− dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2 −/− Il2rg −/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.

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Dendritic cells in cancer immunology

Article Open access 03 September 2021

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Acknowledgements

We thank F. Housseau for communicating his data on IKDCs and providing reagents, J. Tschopp (University of Lausanne) and G. Salvesen (Burnham Institute) for providing plasmids and M.L. Albert (Pasteur Institute) for providing reagents. J. Taieb is supported by a Poste d'accueil INSERM and AP-HP, and N. Chaput is supported by a European fellowship (QLRT-2001-00093) and by the Association for Research Against Cancer (ARC). E. Ullrich was supported by the Deutsche Forschungsgemeinschaft and M. Bonmort by the Poste d' Accueil INSERM. This work was also supported by EU grants (ALLOSTEM, DC THERA), ARC and the Ligue Nationale contre le Cancer (équipes labelisées de G.K. and L.Z).

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Author notes

  1. Julien Taieb, Nathalie Chaput and Cédric Ménard: These authors contributed equally to this work.

Authors and Affiliations

  1. ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Julien Taieb, Nathalie Chaput, Cédric Ménard, Lionel Apetoh, Evelyn Ullrich, Mathieu Bonmort, Magali Terme, Caroline Flament, Paule Opolon, François Ghiringhelli, Thomas Tursz & Laurence Zitvogel
  2. CNRS-UMR8125, Institut Gustave Roussy, Villejuif, France
    Marie Péquignot, Noelia Casares, Didier Métivier & Guido Kroemer
  3. Flow Cytometry Core Facility, IFR54, Institut Gustave Roussy, Villejuif, France
    Yann Lecluse
  4. Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS–Univ. Méditerranée, Campus de Luminy, Marseille, France
    Elena Tomasello & Eric Vivier
  5. Unité INSERM 517, Faculté de Médecine, Dijon, France
    François Martin
  6. Biologie et Thérapeutiques des Pathologies Immunitaires UMPC-CNRSUMR7087, Groupe Hospitalier Pitié Salpétrière, CERVI, Paris, France
    David Klatzmann
  7. Department of Gastroenterology, Hôpital Pitié Salpétrière, AH-HP, Paris, France
    Thierry Poynard
  8. CNRS-UMR144, Institut Curie, Paris, France
    Graça Raposo
  9. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Hideo Yagita
  10. IEM 2815, CNRS, Institut Transgénose, Orléans, France
    Bernard Ryffel

Authors

  1. Julien Taieb
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  2. Nathalie Chaput
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  3. Cédric Ménard
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  4. Lionel Apetoh
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  5. Evelyn Ullrich
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  6. Mathieu Bonmort
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  7. Marie Péquignot
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  8. Noelia Casares
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  9. Magali Terme
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  10. Caroline Flament
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  11. Paule Opolon
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  12. Yann Lecluse
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  13. Didier Métivier
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  14. Elena Tomasello
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  15. Eric Vivier
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  16. François Ghiringhelli
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  17. François Martin
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  18. David Klatzmann
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  19. Thierry Poynard
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  20. Thomas Tursz
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  21. Graça Raposo
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  22. Hideo Yagita
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  23. Bernard Ryffel
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  24. Guido Kroemer
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  25. Laurence Zitvogel
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Corresponding author

Correspondence toLaurence Zitvogel.

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Taieb, J., Chaput, N., Ménard, C. et al. A novel dendritic cell subset involved in tumor immunosurveillance.Nat Med 12, 214–219 (2006). https://doi.org/10.1038/nm1356

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