A novel dendritic cell subset involved in tumor immunosurveillance (original) (raw)
- Letter
- Published: 29 January 2006
- Nathalie Chaput1 na1,
- Cédric Ménard1 na1,
- Lionel Apetoh1,
- Evelyn Ullrich1,
- Mathieu Bonmort1,
- Marie Péquignot2,
- Noelia Casares2,
- Magali Terme1,
- Caroline Flament1,
- Paule Opolon1,
- Yann Lecluse3,
- Didier Métivier2,
- Elena Tomasello4,
- Eric Vivier4,
- François Ghiringhelli1,
- François Martin5,
- David Klatzmann6,
- Thierry Poynard7,
- Thomas Tursz1,
- Graça Raposo8,
- Hideo Yagita9,
- Bernard Ryffel10,
- Guido Kroemer2 &
- …
- Laurence Zitvogel1
Nature Medicine volume 12, pages 214–219 (2006)Cite this article
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Abstract
The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C− dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2 −/− Il2rg −/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.
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Acknowledgements
We thank F. Housseau for communicating his data on IKDCs and providing reagents, J. Tschopp (University of Lausanne) and G. Salvesen (Burnham Institute) for providing plasmids and M.L. Albert (Pasteur Institute) for providing reagents. J. Taieb is supported by a Poste d'accueil INSERM and AP-HP, and N. Chaput is supported by a European fellowship (QLRT-2001-00093) and by the Association for Research Against Cancer (ARC). E. Ullrich was supported by the Deutsche Forschungsgemeinschaft and M. Bonmort by the Poste d' Accueil INSERM. This work was also supported by EU grants (ALLOSTEM, DC THERA), ARC and the Ligue Nationale contre le Cancer (équipes labelisées de G.K. and L.Z).
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Author notes
- Julien Taieb, Nathalie Chaput and Cédric Ménard: These authors contributed equally to this work.
Authors and Affiliations
- ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
Julien Taieb, Nathalie Chaput, Cédric Ménard, Lionel Apetoh, Evelyn Ullrich, Mathieu Bonmort, Magali Terme, Caroline Flament, Paule Opolon, François Ghiringhelli, Thomas Tursz & Laurence Zitvogel - CNRS-UMR8125, Institut Gustave Roussy, Villejuif, France
Marie Péquignot, Noelia Casares, Didier Métivier & Guido Kroemer - Flow Cytometry Core Facility, IFR54, Institut Gustave Roussy, Villejuif, France
Yann Lecluse - Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS–Univ. Méditerranée, Campus de Luminy, Marseille, France
Elena Tomasello & Eric Vivier - Unité INSERM 517, Faculté de Médecine, Dijon, France
François Martin - Biologie et Thérapeutiques des Pathologies Immunitaires UMPC-CNRSUMR7087, Groupe Hospitalier Pitié Salpétrière, CERVI, Paris, France
David Klatzmann - Department of Gastroenterology, Hôpital Pitié Salpétrière, AH-HP, Paris, France
Thierry Poynard - CNRS-UMR144, Institut Curie, Paris, France
Graça Raposo - Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Hideo Yagita - IEM 2815, CNRS, Institut Transgénose, Orléans, France
Bernard Ryffel
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Taieb, J., Chaput, N., Ménard, C. et al. A novel dendritic cell subset involved in tumor immunosurveillance.Nat Med 12, 214–219 (2006). https://doi.org/10.1038/nm1356
- Received: 28 July 2005
- Accepted: 05 December 2005
- Published: 29 January 2006
- Issue Date: 01 February 2006
- DOI: https://doi.org/10.1038/nm1356