Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity (original) (raw)

• Simmons, D.L., Botting, R.M. & Hla, T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol. Rev. 56, 387–437 (2004).
  Article CAS Google Scholar
• Hata, A.N. & Breyer, R.M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103, 147–166 (2004).
  Article CAS Google Scholar
• Minghetti, L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J. Neuropathol. Exp. Neurol. 63, 901–910 (2004).
  Article CAS Google Scholar
• Chen, C. & Bazan, N.G. Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Prostaglandins Other Lipid Mediat. 77, 65–76 (2005).
  Article CAS Google Scholar
• Niwa, K., Araki, E., Morham, S.G., Ross, M.E. & Iadecola, C. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J. Neurosci. 20, 763–770 (2000).
  Article CAS Google Scholar
• FitzGerald, G.A. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat. Rev. Drug Discov. 2, 879–890 (2003).
  Article CAS Google Scholar
• Topol, E.J. Failing the public health—rofecoxib, Merck, and the FDA. N. Engl. J. Med. 351, 1707–1709 (2004).
  Article CAS Google Scholar
• Manabe, Y. et al. Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Ann. Neurol. 55, 668–675 (2004).
  Article CAS Google Scholar
• Carlson, N.G. Neuroprotection of cultured cortical neurons mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid. J. Neurosci. Res. 71, 79–88 (2003).
  Article CAS Google Scholar
• Bilak, M. et al. PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis. Ann. Neurol. 56, 240–248 (2004).
  Article CAS Google Scholar
• McCullough, L. et al. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J. Neurosci. 24, 257–268 (2004).
  Article CAS Google Scholar
• Ahmad, A.S., Ahmad, M., de Brum-Fernandes, A.J. & Dore, S. Prostaglandin EP4 receptor agonist protects against acute neurotoxicity. Brain Res. 1066, 71–77 (2005).
  Article CAS Google Scholar
• Suganami, T. et al. Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats. Hypertension 42, 1183–1190 (2003).
  Article CAS Google Scholar
• Hallinan, E.A. et al. Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs. J. Med. Chem. 39, 609–613 (1996).
  Article CAS Google Scholar
• Audoly, L.P. et al. Identification of specific EP receptors responsible for the hemodynamic effects of PGE2. Am. J. Physiol. 277, H924–H930 (1999).
  CAS PubMed Google Scholar
• Nogawa, S., Zhang, F., Ross, M.E. & Iadecola, C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 17, 2746–2755 (1997).
  Article CAS Google Scholar
• Caggiano, A.O. & Kraig, R.P. Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1β production. J. Neurochem. 72, 565–575 (1999).
  Article CAS Google Scholar
• Ladeby, R. et al. Microglial cell population dynamics in the injured adult central nervous system. Brain Res. Brain Res. Rev. 48, 196–206 (2005).
  Article CAS Google Scholar
• Iadecola, C. et al. Reduced susceptibility to ischemic brain injury and NMDA-mediated neurotoxicity in cyclooxygenase-2 deficient mice. Proc. Natl. Acad. Sci. USA 98, 1294–1299 (2001).
  Article CAS Google Scholar
• Sattler, R. & Tymianski, M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol. Neurobiol. 24, 107–129 (2001).
  Article CAS Google Scholar
• Choi, D.W. Neurodegeneration: cellular defences destroyed. Nature 433, 696–698 (2005).
  Article CAS Google Scholar
• Funk, C.D. et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J. Biol. Chem. 268, 26767–26772 (1993).
  CAS PubMed Google Scholar
• Randall, R.D. & Thayer, S.A. Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J. Neurosci. 12, 1882–1895 (1992).
  Article CAS Google Scholar
• Tymianski, M., Charlton, M.P., Carlen, P.L. & Tator, C.H. Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators. Brain Res. 607, 319–323 (1993).
  Article CAS Google Scholar
• Khodorov, B. Glutamate-induced deregulation of calcium homeostasis and mitochondrial dysfunction in mammalian central neurones. Prog. Biophys. Mol. Biol. 86, 279–351 (2004).
  Article CAS Google Scholar
• Bano, D. et al. Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell 120, 275–285 (2005).
  Article CAS Google Scholar
• Annunziato, L., Pignataro, G. & Di Renzo, G.F. Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol. Rev. 56, 633–654 (2004).
  Article CAS Google Scholar
• Khodorov, B. et al. On the origin of a sustained increase in cytosolic Ca2+ concentration after a toxic glutamate treatment of the nerve cell culture. FEBS Lett. 324, 271–273 (1993).
  Article CAS Google Scholar
• Kiedrowski, L. _N_-methyl-D-aspartate excitotoxicity: relationships among plasma membrane potential, Na+/Ca2+ exchange, mitochondrial Ca2+ overload, and cytoplasmic concentrations of Ca2+, H+, and K+. Mol. Pharmacol. 56, 619–632 (1999).
  Article CAS Google Scholar
• Cho, S. et al. The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J. Neurosci. 25, 2504–2512 (2005).
  Article CAS Google Scholar