Soluble endoglin contributes to the pathogenesis of preeclampsia (original) (raw)
Sibai, B., Dekker, G. & Kupferminc, M. Pre-eclampsia. Lancet365, 785–799 (2005). Article Google Scholar
Weinstein, L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am. J. Obstet. Gynecol.142, 159–167 (1982). ArticleCAS Google Scholar
Roberts, J.M. et al. Preeclampsia: an endothelial cell disorder. Am. J. Obstet. Gynecol.161, 1200–1204 (1989). ArticleCAS Google Scholar
Maynard, S.E. et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest.111, 649–658 (2003). ArticleCAS Google Scholar
Zhou, Y. et al. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am. J. Pathol.160, 1405–1423 (2002). ArticleCAS Google Scholar
Ahmad, S. & Ahmed, A. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ. Res.95, 884–891 (2004). ArticleCAS Google Scholar
Chaiworapongsa, T. et al. Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator Award. Am. J. Obstet. Gynecol.190, 1541–1547; discussion 1547–1550 (2004). ArticleCAS Google Scholar
Taylor, R.N. et al. Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies. Am. J. Obstet. Gynecol.188, 177–182 (2003). ArticleCAS Google Scholar
Levine, R.J. et al. Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med.350, 672–683 (2004). ArticleCAS Google Scholar
Chaiworapongsa, T. et al. Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia. J. Matern. Fetal Neonatal Med.17, 3–18 (2005). ArticleCAS Google Scholar
Hertig, A. et al. Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia. Clin. Chem.50, 1702–1703 (2004). ArticleCAS Google Scholar
Romero, R. et al. Clinical significance, prevalence, and natural history of thrombocytopenia in pregnancy-induced hypertension. Am. J. Perinatol.6, 32–38 (1989). ArticleCAS Google Scholar
Cheifetz, S. et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J. Biol. Chem.267, 19027–19030 (1992). CASPubMed Google Scholar
Gougos, A. et al. Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts. Int. Immunol.4, 83–92 (1992). ArticleCAS Google Scholar
St-Jacques, S., Forte, M., Lye, S.J. & Letarte, M. Localization of endoglin, a transforming growth factor-beta binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy. Biol. Reprod.51, 405–413 (1994). ArticleCAS Google Scholar
McAllister, K.A. et al. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat. Genet.8, 345–351 (1994). ArticleCAS Google Scholar
Bourdeau, A., Dumont, D.J. & Letarte, M. A murine model of hereditary hemorrhagic telangiectasia. J. Clin. Invest.104, 1343–1351 (1999). ArticleCAS Google Scholar
Li, D.Y. et al. Defective angiogenesis in mice lacking endoglin. Science284, 1534–1537 (1999). ArticleCAS Google Scholar
Toporsian, M. et al. A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ. Res.96, 684–692 (2005). ArticleCAS Google Scholar
Dimmeler, S., Dernbach, E. & Zeiher, A.M. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett.477, 258–262 (2000). ArticleCAS Google Scholar
Garcia-Cardena, G. et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature392, 821–824 (1998). ArticleCAS Google Scholar
Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B.E. & Busse, R. Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ. Res.88, E68–E75 (2001). CASPubMed Google Scholar
Brown, M.A., Zammit, V.C. & Lowe, S.A. Capillary permeability and extracellular fluid volumes in pregnancy-induced hypertension. Clin. Sci. (Lond.)77, 599–604 (1989). ArticleCAS Google Scholar
Inoue, N. et al. Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. Arterioscler. Thromb. Vasc. Biol.15, 1255–1261 (1995). ArticleCAS Google Scholar
Saura, M. et al. Smad2 mediates transforming growth factor-β induction of endothelial nitric oxide synthase expression. Circ. Res.91, 806–813 (2002). ArticleCAS Google Scholar
Bdolah, Y., Sukhatme, V.P. & Karumanchi, S.A. Angiogenic imbalance in the pathophysiology of preeclampsia: newer insights. Semin. Nephrol.24, 548–556 (2004). Article Google Scholar
Redman, C.W. & Sargent, I.L. Latest advances in understanding preeclampsia. Science308, 1592–1594 (2005). ArticleCAS Google Scholar
Li, C. et al. Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer. Int. J. Cancer89, 122–126 (2000). ArticleCAS Google Scholar
Velasco-Loyden, G., Arribas, J. & Lopez-Casillas, F. The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1. J. Biol. Chem.279, 7721–7733 (2004). ArticleCAS Google Scholar
Benian, A., Madazli, R., Aksu, F., Uzun, H. & Aydin, S. Plasma and placental levels of interleukin-10, transforming growth factor-β1, and epithelial-cadherin in preeclampsia. Obstet. Gynecol.100, 327–331 (2002). CASPubMed Google Scholar
Muy-Rivera, M. et al. Transforming growth factor-β1 (TGF-β1) in plasma is associated with preeclampsia risk in Peruvian women with systemic inflammation. Am. J. Hypertens.17, 334–338 (2004). ArticleCAS Google Scholar
Hennessy, A. et al. Transforming growth factor-β 1 does not relate to hypertension in pre-eclampsia. Clin. Exp. Pharmacol. Physiol.29, 968–971 (2002). ArticleCAS Google Scholar
Barbara, N.P., Wrana, J.L. & Letarte, M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J. Biol. Chem.274, 584–594 (1999). ArticleCAS Google Scholar
Shesely, E.G. et al. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA93, 13176–13181 (1996). ArticleCAS Google Scholar
Lowe, D.T. Nitric oxide dysfunction in the pathophysiology of preeclampsia. Nitric Oxide4, 441–458 (2000). ArticleCAS Google Scholar
Papapetropoulos, A., Garcia-Cardena, G., Madri, J.A. & Sessa, W.C. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Invest.100, 3131–3139 (1997). ArticleCAS Google Scholar
Predescu, D., Predescu, S., Shimizu, J., Miyawaki-Shimizu, K. & Malik, A.B. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am. J. Physiol. Lung Cell. Mol. Physiol.289, L371–L381 (2005). ArticleCAS Google Scholar
Tatsumi, M., Kishi, Y., Miyata, T. & Numano, F. Transforming growth factor-beta(1) restores antiplatelet function of endothelial cells exposed to anoxia-reoxygenation injury. Thromb. Res.98, 451–459 (2000). ArticleCAS Google Scholar
Ristimaki, A., Ylikorkala, O. & Viinikka, L. Effect of growth factors on human vascular endothelial cell prostacyclin production. Arteriosclerosis10, 653–657 (1990). ArticleCAS Google Scholar
He, H. et al. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. J. Biol. Chem.274, 25130–25135 (1999). ArticleCAS Google Scholar
Mills, J.L. et al. Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study. J. Am. Med. Assoc.282, 356–362 (1999). ArticleCAS Google Scholar
Darland, D.C. et al. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev. Biol.264, 275–288 (2003). ArticleCAS Google Scholar
Zhou, Y. et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J. Clin. Invest.99, 2139–2151 (1997). ArticleCAS Google Scholar
Zhou, Y., Damsky, C.H. & Fisher, S.J. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J. Clin. Invest.99, 2152–2164 (1997). ArticleCAS Google Scholar
Caniggia, I., Taylor, C.V., Ritchie, J.W., Lye, S.J. & Letarte, M. Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants. Endocrinology138, 4977–4988 (1997). ArticleCAS Google Scholar
Fonsatti, E., Altomonte, M., Arslan, P. & Maio, M. Endoglin (CD105): a target for anti-angiogenetic cancer therapy. Curr. Drug Targets4, 291–296 (2003). ArticleCAS Google Scholar
Holash, J. et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl. Acad. Sci. USA99, 11393–11398 (2002). ArticleCAS Google Scholar
ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet. Gynecol.99, 159–167 (2002).
Kuo, C.J. et al. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc. Natl. Acad. Sci. USA98, 4605–4610 (2001). ArticleCAS Google Scholar
Akiyoshi, S. et al. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J. Biol. Chem.274, 35269–35277 (1999). ArticleCAS Google Scholar