Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells (original) (raw)
- Brief Communication
- Published: 21 December 2003
- Yoichi Maekawa1,
- Daiji Iwakawa1,
- Hiroko Okada1,
- Kunisuke Himeno2,
- Kenji Kishihara1,
- Shin-ichi Tsukumo1 &
- …
- Koji Yasutomo1
Nature Medicine volume 10, pages 29–30 (2004)Cite this article
- 1395 Accesses
- 284 Citations
- 7 Altmetric
- Metrics details
Abstract
Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4+CD25+ regulatory T cells (Treg) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of Treg cells contributes to immune suppression during malaria infection, and helps malaria parasites to escape from host immune responses.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Richie, T.L. & Saul, A. Nature 415, 694–701 (2002).
Article CAS Google Scholar - Good, M.F., Kaslow, D.C. & Miller, L.H. Annu. Rev. Immunol. 16, 57–87 (1998).
Article CAS Google Scholar - Plebanski, M. et al. Immunity 10, 651–660 (1999).
Article CAS Google Scholar - Chen, Q. et al. Nature 394, 392–395 (1998).
Article CAS Google Scholar - Su, X.Z. et al. Cell 82, 89–100 (1995).
Article CAS Google Scholar - Baruch, D.I. et al. Cell 82, 77–87 (1995).
Article CAS Google Scholar - Urban, B.C. et al. Nature 400, 73–77 (1999).
Article CAS Google Scholar - Williamson, W.A. & Greenwood, B.M. Lancet 1, 1328–1329 (1978).
Article CAS Google Scholar - Viens, P., Tarzaali, A. & Quevillon, M. Am. J. Trop. Med. Hyg. 23, 846–849 (1974).
Article CAS Google Scholar - Ho, M. et al. J. Immunol. 141, 2755–2759 (1988).
CAS PubMed Google Scholar - Shevach, E.M., McHugh, R.S., Piccirillo, C.A. & Thornton, A.M. Immunol. Rev. 182, 58–67 (2001).
Article CAS Google Scholar - Shevach, E.M. J. Exp. Med. 193, F41–F46 (2001).
Article CAS Google Scholar - Sakaguchi, S. Cell 101, 455–458 (2000).
Article CAS Google Scholar - Belkaid, Y., Piccirillo, C.A., Mendez, S., Shevach, E.M. & Sacks, D.L. Nature 420, 502–507 (2002).
Article CAS Google Scholar - Yoeli, M., Hargreaves, B., Carter, R. & Walliker, D. Ann. Trop. Med. Parasitol. 69, 173–178 (1975).
Article CAS Google Scholar
Acknowledgements
We thank M. Tsubosaka, N. Kanbe, K. Ishii and S. Hamano for assistance with experiments, and J.R. Dorfman for helpful comments. This work was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology in Japan and the Industrial Technology Research Grant Program from NEDO of Japan (to K.Y.). The experiments were approved by the animal care committee of the University of Tokushima.
Author information
Authors and Affiliations
- Department of Immunology & Parasitology, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan
Hajime Hisaeda, Yoichi Maekawa, Daiji Iwakawa, Hiroko Okada, Kenji Kishihara, Shin-ichi Tsukumo & Koji Yasutomo - Department of Parasitology, Faculty of Medical Sciences, Kyushu University, 3 Maidashi, East Ward Fukuoka, 812-8582, Japan
Kunisuke Himeno
Authors
- Hajime Hisaeda
You can also search for this author inPubMed Google Scholar - Yoichi Maekawa
You can also search for this author inPubMed Google Scholar - Daiji Iwakawa
You can also search for this author inPubMed Google Scholar - Hiroko Okada
You can also search for this author inPubMed Google Scholar - Kunisuke Himeno
You can also search for this author inPubMed Google Scholar - Kenji Kishihara
You can also search for this author inPubMed Google Scholar - Shin-ichi Tsukumo
You can also search for this author inPubMed Google Scholar - Koji Yasutomo
You can also search for this author inPubMed Google Scholar
Corresponding author
Correspondence toKoji Yasutomo.
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Hisaeda, H., Maekawa, Y., Iwakawa, D. et al. Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells.Nat Med 10, 29–30 (2004). https://doi.org/10.1038/nm975
- Received: 24 September 2003
- Accepted: 03 December 2003
- Published: 21 December 2003
- Issue Date: 01 January 2004
- DOI: https://doi.org/10.1038/nm975