Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection (original) (raw)

• Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B. & Papahadjopoulos, D. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol. Rev. 51, 691–743 (1999).
  CAS Google Scholar
• Duncan, R. Polymer conjugates as anticancer nanomedicines. Nature Rev. Cancer 6, 688–701 (2006).
  CAS Google Scholar
• Lee, C. C., MacKay, J. A., Frechet, J. M. & Szoka, F. C. Designing dendrimers for biological applications. Nature Biotechnol. 23, 1517–1526 (2005).
  Article CAS Google Scholar
• Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387–6392 (1986).
  CAS Google Scholar
• Brannon-Peppas, L. & Blanchette, J. O. Nanoparticle and targeted systems for cancer therapy. Adv. Drug Deliv. Rev. 56, 1649–1659 (2004).
  Article CAS Google Scholar
• Urry, D. W. Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers. J. Phys. Chem. B 101, 11007–11028 (1997).
  Article CAS Google Scholar
• Yamaoka, T. et al. Mechanism for the phase transition of a genetically engineered elastin model peptide (VPGIG)(40) in aqueous solution. Biomacromolecules 4, 1680–1685 (2003).
  Article CAS Google Scholar
• Cappello, J. et al. In situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs. J. Control. Release 53, 105–117 (1998).
  Article CAS Google Scholar
• Dreher, M. R. et al. Temperature triggered self-assembly of polypeptides into multivalent spherical micelles. J. Am. Chem. Soc. 130, 687–694 (2008).
  Article CAS Google Scholar
• Wright, E. R. & Conticello, V. P. Self-assembly of block copolymers derived from elastin-mimetic polypeptide sequences. Adv. Drug Deliv. Rev. 54, 1057–1073 (2002).
  Article CAS Google Scholar
• Megeed, Z., Cappello, J. & Ghandehari, H. Genetically engineered silk-elastinlike protein polymers for controlled drug delivery. Adv. Drug Deliv. Rev. 54, 1075–1091 (2002).
  Article CAS Google Scholar
• Urry, D. W., Parker, T. M., Reid, M. C. & Gowda, D. C. Biocompatibility of the bioelastic materials, poly(Gvgvp) and its gamma-irradiation cross-linked matrix—summary of generic biological test-results. J. Bioact. Compat. Polym. 6, 263–282 (1991).
  Article CAS Google Scholar
• Liu, W. et al. Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice. J. Control. Release 116, 170–178 (2006).
  Article CAS Google Scholar
• Chilkoti, A., Dreher, M. R. & Meyer, D. E. Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. Adv. Drug Deliv. Rev. 54, 1093–1111 (2002).
  Article CAS Google Scholar
• Meyer, D. E. & Chilkoti, A. Purification of recombinant proteins by fusion with thermally-responsive polypeptides. Nature Biotechnol. 17, 1112–1115 (1999).
  Article CAS Google Scholar
• Furgeson, D. Y., Dreher, M. R. & Chilkoti, A. Structural optimization of a ‘smart’ doxorubicin–polypeptide conjugate for thermally targeted delivery to solid tumors. J. Control. Release 110, 362–369 (2006).
  Article CAS Google Scholar
• Rodrigues, P. C. et al. Acid-sensitive polyethylene glycol conjugates of doxorubicin: Preparation, in vitro efficacy and intracellular distribution. Bioorg. Med. Chem. 7, 2517–2524 (1999).
  Article CAS Google Scholar
• Bae, Y. et al. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug. Chem. 16, 122–130 (2005).
  Article CAS Google Scholar
• Dreher, M. R. et al. Evaluation of an elastin-like polypeptide–doxorubicin conjugate for cancer therapy. J. Control. Release 91, 31–43 (2003).
  Article CAS Google Scholar
• Lopes de Menezes, D. E. & Mayer, L. D. Pharmacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts. Cancer Chemother. Pharmacol. 49, 57–68 (2002).
  Article CAS Google Scholar
• Singal, P. K. & Iliskovic, N. Doxorubicin-induced cardiomyopathy. N. Engl. J. Med. 339, 900–905 (1998).
  Article CAS Google Scholar
• Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. & Liu, L. F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 226, 466–468 (1984).
  Article CAS Google Scholar
• Nitiss, J. L. Targeting DNA topoisomerase II in cancer chemotherapy. Nature Rev. Cancer 9, 338–350 (2009).
  CAS Google Scholar
• Drummond, J. T., Anthoney, A., Brown, R. & Modrich, P. Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem. 271, 19645–19648 (1996).
  Article CAS Google Scholar
• Hao, X. Y., Bergh, J., Brodin, O., Hellman, U. & Mannervik, B. Acquired resistance to cisplatin and doxorubicin in a small cell lung cancer cell line is correlated to elevated expression of glutathione-linked detoxification enzymes. Carcinogenesis 5, 1167–1173 (1994).
  Article Google Scholar
• Kabanov, A. V. et al. Polymer genomics: Shifting the gene and drug delivery paradigms. J. Control. Release 101, 259–271 (2005).
  Article CAS Google Scholar
• Kabanov, A. V. Polymer genomics: An insight into pharmacology and toxicology of nanomedicines. Adv. Drug Deliv. Rev. 58, 1597–1621 (2006).
  Article CAS Google Scholar
• Batrakova, E. V. et al. Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: Pluronic P85. Mol. Pharmaceut. 3, 113–123 (2006).
  Article CAS Google Scholar
• Veronese, F. M. et al. PEG-doxorubicin conjugates: Influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity. Bioconjug. Chem. 16, 775–784 (2005).
  Article CAS Google Scholar
• Kwon, G. et al. Block copolymer micelles for drug delivery: Loading and release of doxorubicin. J. Control. Release 48, 195–201 (1997).
  Article CAS Google Scholar
• Kataoka, K., Kwon, G. S., Yokoyama, M., Okano, T. & Sakurai, Y. Block-copolymer micelles as vehicles for drug delivery. J. Control. Release 24, 119–132 (1993).
  Article CAS Google Scholar
• Kataoka, K., Harada, A. & Nagasaki, Y. Block copolymer micelles for drug delivery: Design, characterization and biological significance. Adv. Drug Deliv. Rev. 47, 113–131 (2001).
  Article CAS Google Scholar
• Ulbrich, K. et al. Polymeric anticancer drugs with pH-controlled activation. Int. J. Pharmaceut. 277, 63–72 (2004).
  Article CAS Google Scholar
• Chytil, P. et al. New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting. J. Control. Release 127, 121–130 (2008).
  Article CAS Google Scholar
• Anton, N., Benoit, J. P. & Saulnier, P. Design and production of nanoparticles formulated from nano-emulsion templates—a review. J. Control. Release 128, 185–199 (2008).
  Article CAS Google Scholar
• Huang, X., Jain, P. K., El-Sayed, I. H. & El-Sayed, M. A. Gold nanoparticles: Interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine 2, 681–693 (2007).
  Article CAS Google Scholar
• Martin, C. R. & Kohli, P. The emerging field of nanotube biotechnology. Nat. Rev. Drug Discov. 2, 29–37 (2003).
  Article CAS Google Scholar
• Nori, A. & Kopecek, J. Intracellular targeting of polymer-bound drugs for cancer chemotherapy. Adv. Drug Deliv. Rev. 57, 609–636 (2005).
  Article CAS Google Scholar
• Kratz, F. et al. Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates. Bioorg. Med. Chem. Lett. 11, 2001–2006 (2001).
  Article CAS Google Scholar