Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system (original) (raw)

Nature Methods volume 3, page 767 (2006)Cite this article

To the editor:

The concomitant appearance of motor disability and cognitive deficits is very common in neurodegenerative disease1. Although progress in developing valuable mouse models for these diseases has been excellent, there are few cognitive tests suitable for animals with motor impairments. To tackle this problem, we used an automated touchscreen-based cognitive-testing system2 that can be used to test mice with motor impairments.

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Figure 1: Cognitive deficits in a two-choice discrimination task are detected in R6/2 mice using an interactive touchscreen system.

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Acknowledgements

This work was supported by a grant from the HighQ Foundation.

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Authors and Affiliations

  1. Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK
    A Jennifer Morton & Elizabeth Skillings
  2. Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 1PD, UK
    Timothy J Bussey & Lisa M Saksida

Authors

  1. A Jennifer Morton
  2. Elizabeth Skillings
  3. Timothy J Bussey
  4. Lisa M Saksida

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Morton, A., Skillings, E., Bussey, T. et al. Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system.Nat Methods 3, 767 (2006). https://doi.org/10.1038/nmeth1006-767

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