The precision of remote context memories does not require the hippocampus (original) (raw)

Nature Neuroscience volume 12, pages 253–255 (2009)Cite this article

Abstract

Although the clarity of many memories fades with time, some memories may maintain their original precision. Here we used a context discrimination procedure to evaluate whether the hippocampus is important in maintaining precision as memories mature. Spared discrimination in hippocampal-lesioned mice indicated that precise, remote context memories may be supported by extra-hippocampal brain regions.

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Acknowledgements

We thank S. Josselyn, B. Wiltgen and A. Corvelo for comments on this manuscript. This work was supported by grants from the Canadian Institutes of Health Research (MOP-77561) and the EJLB Foundation (P.W.F.). C.M.T. and A.L.W. received support from the Ontario Ministry of Research and Innovation and the Ontario Mental Health Foundation, respectively.

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Author notes

  1. Szu-Han Wang
    Present address: Present address: Centre for Cognitive and Neural Systems, Edinburgh University, Edinburgh, EH8 9JZ, UK.,

Authors and Affiliations

  1. Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada
    Szu-Han Wang, Cátia M Teixeira, Anne L Wheeler & Paul W Frankland
  2. Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, Canada
    Szu-Han Wang, Cátia M Teixeira & Paul W Frankland
  3. Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, Canada
    Szu-Han Wang, Cátia M Teixeira, Anne L Wheeler & Paul W Frankland

Authors

  1. Szu-Han Wang
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  2. Cátia M Teixeira
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  3. Anne L Wheeler
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  4. Paul W Frankland
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Contributions

S.-H.W. and P.W.F. conceived and designed the experiments. S.-H.W., C.M.T. and A.L.W. performed the behavioral studies and carried out the statistical analyses. S.-H.W. conducted the lesions and histological analyses. P.W.F. supervised the project and wrote the paper with S.-H.W.

Corresponding author

Correspondence toPaul W Frankland.

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Wang, SH., Teixeira, C., Wheeler, A. et al. The precision of remote context memories does not require the hippocampus.Nat Neurosci 12, 253–255 (2009). https://doi.org/10.1038/nn.2263

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