Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease (original) (raw)
Arendt, T. Synaptic degeneration in Alzheimer′s disease. Acta Neuropathol.118, 167–179 (2009). Article Google Scholar
Morrison, J.H. & Hof, P.R. Life and death of neurons in the aging brain. Science278, 412–419 (1997). ArticleCAS Google Scholar
Bookheimer, S.Y. et al. Patterns of brain activation in people at risk for Alzheimer′s disease. N. Engl. J. Med.343, 450–456 (2000). ArticleCAS Google Scholar
Elias, M.F. et al. The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham cohort. Arch. Neurol.57, 808–813 (2000). ArticleCAS Google Scholar
Zhou, Y. et al. Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment. Alzheimers Dement.4, 265–270 (2008). Article Google Scholar
Scheff, S.W., Price, D.A., Schmitt, F.A., DeKosky, S.T. & Mufson, E.J. Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology68, 1501–1508 (2007). ArticleCAS Google Scholar
Bourne, J.N. & Harris, K.M. Balancing structure and function at hippocampal dendritic spines. Annu. Rev. Neurosci.31, 47–67 (2008). ArticleCAS Google Scholar
Ferrer, I., Guionnet, N., Cruz-Sánchez, F. & Tuñón, T. Neuronal alterations in patients with dementia: a Golgi study on biopsy samples. Neurosci. Lett.114, 11–16 (1990). ArticleCAS Google Scholar
Lanz, T.A., Carter, D.B. & Merchant, K.M. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol. Dis.13, 246–253 (2003). ArticleCAS Google Scholar
Mattson, M.P., Keller, J.N. & Begley, J.G. Evidence for synaptic apoptosis. Exp. Neurol.153, 35–48 (1998). ArticleCAS Google Scholar
Hsiao, K. et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science274, 99–102 (1996). ArticleCAS Google Scholar
Jacobsen, J.S. et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer′s disease. Proc. Natl. Acad. Sci. USA103, 5161–5166 (2006). ArticleCAS Google Scholar
Kawarabayashi, T. et al. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer′s disease. J. Neurosci.21, 372–381 (2001). ArticleCAS Google Scholar
Irizarry, M.C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol.56, 965–973 (1997). ArticleCAS Google Scholar
Westerman, M.A. et al. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer′s disease. J. Neurosci.22, 1858–1867 (2002). ArticleCAS Google Scholar
Janus, C. et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer′s disease. Nature408, 979–982 (2000). ArticleCAS Google Scholar
Chen, G. et al. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer′s disease. Nature408, 975–979 (2000). ArticleCAS Google Scholar
Phillips, R.G. & LeDoux, J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci.106, 274–285 (1992). ArticleCAS Google Scholar
Lee, I. & Kesner, R.P. Differential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning. Hippocampus14, 301–310 (2004). Article Google Scholar
Lajtha, A., Perez-Polo, J.R. & Rossner, S. Handbook of Neurochemistry and Molecular Neurobiology (Springer, New York, 2008).
Li, S. et al. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron62, 788–801 (2009). ArticleCAS Google Scholar
Almeida, C.G. et al. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis.20, 187–198 (2005). ArticleCAS Google Scholar
Malinow, R. & Malenka, R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci.25, 103–126 (2002). ArticleCAS Google Scholar
Chapman, P.F. et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci.2, 271–276 (1999). ArticleCAS Google Scholar
Lee, H.K., Kameyama, K., Huganir, R.L. & Bear, M.F. NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron21, 1151–1162 (1998). ArticleCAS Google Scholar
van Engeland, M., Nieland, L.J., Ramaekers, F.C., Schutte, B. & Reutelingsperger, C.P. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry31, 1–9 (1998). ArticleCAS Google Scholar
Green, D.R. & Kroemer, G. The pathophysiology of mitochondrial cell death. Science305, 626–629 (2004). ArticleCAS Google Scholar
Schulze-Osthoff, K., Ferrari, D., Los, M., Wesselborg, S. & Peter, M.E. Apoptosis signaling by death receptors. Eur. J. Biochem.254, 439–459 (1998). ArticleCAS Google Scholar
Hsieh, H. et al. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron52, 831–843 (2006). ArticleCAS Google Scholar
Mukerjee, N., McGinnis, K.M., Park, Y.H., Gnegy, M.E. & Wang, K.K. Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. Arch. Biochem. Biophys.379, 337–343 (2000). ArticleCAS Google Scholar
Vicent, M.J. & Pérez-Payá, E. Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine. J. Med. Chem.49, 3763–3765 (2006). ArticleCAS Google Scholar
Santamaría, B. et al. A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury. PLoS ONE4, e6634 (2009). Article Google Scholar
Salvesen, G.S. & Dixit, V.M. Caspases: intracellular signaling by proteolysis. Cell91, 443–446 (1997). ArticleCAS Google Scholar
Bravarenko, N.I. et al. Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix. Eur. J. Neurosci.23, 129–140 (2006). ArticleCAS Google Scholar
Huesmann, G.R. & Clayton, D.F. Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation. Neuron52, 1061–1072 (2006). ArticleCAS Google Scholar
Li, Z. et al. Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell141, 859–871 (2010). ArticleCAS Google Scholar
Marín, N. et al. Beta-amyloid-induced activation of caspase-3 in primary cultures of rat neurons. Mech. Ageing Dev.119, 63–67 (2000). Article Google Scholar
Gervais, F.G. et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell97, 395–406 (1999). ArticleCAS Google Scholar
Stadelmann, C. et al. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am. J. Pathol.155, 1459–1466 (1999). ArticleCAS Google Scholar
Louneva, N. et al. Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer′s disease. Am. J. Pathol.173, 1488–1495 (2008). ArticleCAS Google Scholar
Kuida, K. et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature384, 368–372 (1996). ArticleCAS Google Scholar
Hakem, R. et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell94, 339–352 (1998). ArticleCAS Google Scholar
Kuida, K. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell94, 325–337 (1998). ArticleCAS Google Scholar
Cecconi, F., Alvarez-Bolado, G., Meyer, B.I., Roth, K.A. & Gruss, P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell94, 727–737 (1998). ArticleCAS Google Scholar
Takahashi, R.H. et al. Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J. Neurosci.24, 3592–3599 (2004). ArticleCAS Google Scholar
Manczak, M. et al. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol. Genet.15, 1437–1449 (2006). ArticleCAS Google Scholar
Cho, D.H. et al. S-nytrosylation of Drp1 mediates beta-amyloid–related mitochondrial fission and neuronal injury. Science324, 102–105 (2009). ArticleCAS Google Scholar
Marie, H., Morishita, W., Yu, X., Calakos, N. & Malenka, R.C. Generation of silent synapses by acute in vivo expression of CaMKIV and CREB. Neuron45, 741–752 (2005). ArticleCAS Google Scholar
Ferri, A. et al. Calcineurin activity is regulated both by redox compounds and by mutant familial amyotrophic lateral sclerosis-superoxide dismutase. J. Neurochem.75, 606–613 (2000). ArticleCAS Google Scholar