Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions (original) (raw)

• Caspi, A. & Moffitt, T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 7, 583–590 (2006).
  Article CAS Google Scholar
• Caspi, A., Hariri, A.R., Holmes, A., Uher, R. & Moffitt, T.E. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 167, 509–527 (2010).
  Article Google Scholar
• Binder, E.B. et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. J. Am. Med. Assoc. 299, 1291–1305 (2008).
  Article CAS Google Scholar
• Heim, C. et al. Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front. Behav. Neurosci. 3, 41 (2009).
  Article Google Scholar
• Xie, P. et al. Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder 3. Neuropsychopharmacology 35, 1684–1692 (2010).
  Article CAS Google Scholar
• Pratt, W.B. & Toft, D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18, 306–360 (1997).
  CAS PubMed Google Scholar
• Binder, E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34 (suppl. 1), S186–S195 (2009).
  Article CAS Google Scholar
• Holsboer, F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23, 477–501 (2000).
  Article CAS Google Scholar
• Heim, C., Newport, D.J., Mletzko, T., Miller, A.H. & Nemeroff, C.B. The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33, 693–710 (2008).
  Article CAS Google Scholar
• Scammell, J.G., Denny, W.B., Valentine, D.L. & Smith, D.F. Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen. Comp. Endocrinol. 124, 152–165 (2001).
  Article CAS Google Scholar
• Wochnik, G.M. et al. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J. Biol. Chem. 280, 4609–4616 (2005).
  Article CAS Google Scholar
• Jääskeläinen, T., Makkonen, H. & Palvimo, J.J. Steroid up-regulation of FKBP51 and its role in hormone signaling 4. Curr. Opin. Pharmacol. 11, 326–331 (2011).
  Article Google Scholar
• Appel, K. et al. Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population. Neuropsychopharmacology 36, 1982–1991 (2011).
  Article Google Scholar
• Koenen, K.C. et al. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol. Psychiatry 10, 1058–1059 (2005).
  Article CAS Google Scholar
• Mehta, D. et al. Using polymorphisms in FKBP5 to define biologically distinct subtypes of post-traumatic stress disorder: evidence from endocrine and gene expression studies. Arch. Gen. Psychiatry 68, 901–910 (2011).
  Article CAS Google Scholar
• Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D. & Enoch, M.A. Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology 35, 1674–1683 (2010).
  Article CAS Google Scholar
• Zimmermann, P. et al. Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. Am. J. Psychiatry 168, 1107–1116 (2011).
  Article Google Scholar
• Binder, E.B. et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment 45. Nat. Genet. 36, 1319–1325 (2004).
  Article CAS Google Scholar
• 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061–1073 (2010).
• Paakinaho, V., Makkonen, H., Jaaskelainen, T. & Palvimo, J.J. Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol. Endocrinol. 24, 511–525 (2010).
  Article CAS Google Scholar
• Ising, M. et al. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur. J. Neurosci. 28, 389–398 (2008).
  Article Google Scholar
• McGowan, P.O. et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12, 342–348 (2009).
  Article CAS Google Scholar
• Murgatroyd, C. et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress 8. Nat. Neurosci. 12, 1559–1566 (2009).
  Article CAS Google Scholar
• Weaver, I.C. et al. Epigenetic programming by maternal behavior. Nat. Neurosci. 7, 847–854 (2004).
  Article CAS Google Scholar
• Thomassin, H., Flavin, M., Espinas, M.L. & Grange, T. Glucocorticoid-induced DNA demethylation and gene memory during development. EMBO J. 20, 1974–1983 (2001).
  Article CAS Google Scholar
• Lee, R.S. et al. Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. Endocrinology 151, 4332–4343 (2010).
  Article CAS Google Scholar
• Pace, T.W. et al. Increased peripheral NF-kappaB pathway activity in women with childhood abuse-related post-traumatic stress disorder. Brain Behav. Immun. 26, 13–17 (2011).
  Article Google Scholar
• Sommershof, A. et al. Substantial reduction of naive and regulatory T cells following traumatic stress 1. Brain Behav. Immun. 23, 1117–1124 (2009).
  Article CAS Google Scholar
• Anacker, C. et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol. Psychiatry 16, 738–750 (2011).
  Article CAS Google Scholar
• Klug, M. & Rehli, M. Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector. Epigenetics 1, 127–130 (2006).
  Article Google Scholar
• Kelder, T. et al. Mining biological pathways using WikiPathways web services 3. PLoS ONE 4, e6447 (2009).
  Article Google Scholar
• Danese, A. et al. Elevated inflammation levels in depressed adults with a history of childhood maltreatment 6. Arch. Gen. Psychiatry 65, 409–415 (2008).
  Article Google Scholar
• Pace, T.W. et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am. J. Psychiatry 163, 1630–1633 (2006).
  Article Google Scholar
• Attwood, B.K. et al. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature 473, 372–375 (2011).
  Article CAS Google Scholar
• Touma, C. et al. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior 1. Biol. Psychiatry 70, 928–936 (2011).
  Article CAS Google Scholar
• O'Leary, J.C. III et al. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS ONE 6, e24840 (2011).
  Article CAS Google Scholar
• Gillespie, C.F. et al. Trauma exposure and stress-related disorders in inner city primary care patients. Gen. Hosp. Psychiatry 31, 505–514 (2009).
  Article Google Scholar
• Bradley, R.G. et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch. Gen. Psychiatry 65, 190–200 (2008).
  Article CAS Google Scholar
• Ressler, K.J. et al. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 470, 492–497 (2011).
  Article CAS Google Scholar
• Fink, L.A., Bernstein, D., Handelsman, L., Foote, J. & Lovejoy, M. Initial reliability and validity of the childhood trauma interview: a new multidimensional measure of childhood interpersonal trauma. Am. J. Psychiatry 152, 1329–1335 (1995).
  Article CAS Google Scholar
• Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies 1. PLoS Genet. 5, e1000529 (2009).
  Article Google Scholar
• Birney, E. et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project 1. Nature 447, 799–816 (2007).
  Article CAS Google Scholar
• Huber, W., von, H.A., Sultmann, H., Poustka, A. & Vingron, M. Variance stabilization applied to microarray data calibration and to the quantification of differential expression 7. Bioinformatics 18 (suppl. 1), S96–S104 (2002).
  Article Google Scholar
• Hagège, H. et al. Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat. Protoc. 2, 1722–1733 (2007).
  Article Google Scholar
• DeRijk, R.H., Petrides, J., Deuster, P., Gold, P.W. & Sternberg, E.M. Changes in corticosteroid sensitivity of peripheral blood lymphocytes after strenuous exercise in humans 2. J. Clin. Endocrinol. Metab. 81, 228–235 (1996).
  CAS PubMed Google Scholar
• Miller, G.E., Rohleder, N., Stetler, C. & Kirschbaum, C. Clinical depression and regulation of the inflammatory response during acute stress 5. Psychosom. Med. 67, 679–687 (2005).
  Article CAS Google Scholar
• Sled, J.G., Zijdenbos, A.P. & Evans, A.C. A nonparametric method for automatic correction of intensity nonuniformity in MRI data 4. IEEE Trans. Med. Imaging 17, 87–97 (1998).
  Article CAS Google Scholar
• Collins, D.L., Neelin, P., Peters, T.M. & Evans, A.C. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J. Comput. Assist. Tomogr. 18, 192–205 (1994).
  Article CAS Google Scholar
• Pruessner, J.C. et al. Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb. Cortex 10, 433–442 (2000).
  Article CAS Google Scholar