Snip-snip, kill-kill: truncated SDF-1 and HIV-associated neurodegeneration (original) (raw)

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• Published: 01 October 2003

Nature Neuroscience volume 6, pages 1009–1011 (2003)Cite this article

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HIV-associated neurodegeneration likely involves release of signals from activated glial cells. A new study reveals that matrix metalloproteinase from HIV-1-infected macrophages or microglia cleaves the chemokine SDF-1 to generate a potent neurotoxin.

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Figure 1: MMP-2 mediated cleavage of SDF-1 at the 4-5 position generates a neurotoxin.

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Authors and Affiliations

1. Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA
   Richard M. Ransohoff

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1. Richard M. Ransohoff
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Ransohoff, R. Snip-snip, kill-kill: truncated SDF-1 and HIV-associated neurodegeneration.Nat Neurosci 6, 1009–1011 (2003). https://doi.org/10.1038/nn1003-1009

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• Issue Date: 01 October 2003
• DOI: https://doi.org/10.1038/nn1003-1009

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