TR(I)Pping towards treatment for ischemia (original) (raw)

Nature Neuroscience volume 12, pages 1215–1216 (2009)Cite this article

A study in this issue found that suppressing expression of TRPM7 in hippocampal CA1 neurons conferred resistance to ischemic cell death, preserved cell function and prevented ischemia-induced deficits in memory.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: The expression and activation mechanisms of TRPM channels.

References

  1. Sun, H.-S. et al. Nat. Neurosci. 12, 1300–1307 (2009).
    Article CAS Google Scholar
  2. Nilius, B. & Voets, T. Pflugers Arch. 451, 1–10 (2005).
    Article CAS Google Scholar
  3. Aarts, M. et al. Cell 115, 863–877 (2003).
    Article CAS Google Scholar
  4. Oancea, E., Wolfe, J.T. & Clapham, D.E. Circ. Res. 98, 245–253 (2006).
    Article CAS Google Scholar
  5. Reading, S.A. & Brayden, J.E. Stroke 38, 2322–2328 (2007).
    Article CAS Google Scholar
  6. Gerzanich, V. et al. Nat. Med. 15, 185–191 (2009).
    Article CAS Google Scholar
  7. Krapivinsky, G. et al. Neuron 52, 485–496 (2006).
    Article CAS Google Scholar
  8. Jin, J. et al. Science 322, 756–760 (2008).
    Article CAS Google Scholar
  9. Schmitz, C. et al. Cell 114, 191–200 (2003).
    Article CAS Google Scholar
  10. McNulty, S. & Fonfria, E. Pflugers Arch. 451, 235–242 (2005).
    Article CAS Google Scholar
  11. Fonfria, E. et al. J. Neurochem. 95, 715–723 (2005).
    Article CAS Google Scholar
  12. Olah, M.E. et al. J. Physiol. (Lond.) 587, 965–979 (2009).
    Article CAS Google Scholar
  13. Kraft, R. et al. Am. J. Physiol. Cell Physiol. 286, C129–C137 (2004).
    Article CAS Google Scholar
  14. Bond, C.E. & Greenfield, S.A. Glia 55, 1348–1361 (2007).
    Article Google Scholar
  15. Besancon, E. et al. Trends Pharmacol. Sci. 29, 268–275 (2008).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. David A. Rempe is in the Department of Neurology, and Takahiro Takano and Maiken Nedergaard are in the Department of Neurosurgery, University of Rochester, Rochester, New York, USA. maiken_nedergaard@urmc.rochester.edu or david_rempe@urmc.rochester.edu,
    David A Rempe, Takahiro Takano & Maiken Nedergaard

Authors

  1. David A Rempe
    You can also search for this author inPubMed Google Scholar
  2. Takahiro Takano
    You can also search for this author inPubMed Google Scholar
  3. Maiken Nedergaard
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Rempe, D., Takano, T. & Nedergaard, M. TR(I)Pping towards treatment for ischemia.Nat Neurosci 12, 1215–1216 (2009). https://doi.org/10.1038/nn1009-1215

Download citation

This article is cited by