Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits (original) (raw)

Nature Neuroscience volume 6, pages 911–912 (2003)Cite this article

Abstract

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks1,2 is correlated with substantial changes in neuronal signal processing in the hippocampus3,4,5. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task6,7.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Houston, F.P., Stevenson, G.D., McNaughton, B.L. & Barnes, C.A. Learn. Mem. 6, 111–119 (1999).
    CAS PubMed PubMed Central Google Scholar
  2. Barnes, C.A., Nadel, L. & Honig, W.K. Can. J. Psychol. 34, 29–39 (1980).
    Article CAS Google Scholar
  3. Landfield, P.W., McGaugh, J.L. & Lynch, G. Brain Res. 150, 85–101 (1978).
    Article CAS Google Scholar
  4. Landfield, P.W. & Pitler, T.A. Science 226, 1089–1092 (1984).
    Article CAS Google Scholar
  5. Wu, W.W., Oh, M.M. & Disterhoft, J.F. Ageing Res. Rev. 1, 181–207 (2002).
    Article CAS Google Scholar
  6. McEchron, M.D., Bouwmeester, H., Tseng, W., Weiss, C. & Disterhoft, J.F. Hippocampus 8, 638–646 (1998).
    Article CAS Google Scholar
  7. Wallenstein, G.V., Eichenbaum, H. & Hasselmo, M.E. Trends Neurosci. 21, 317–323 (1998).
    Article CAS Google Scholar
  8. Storm, J.F. Prog. Brain Res. 83, 161–187 (1990).
    Article CAS Google Scholar
  9. Sah, P. Trends Neurosci. 19, 150–154 (1996).
    Article CAS Google Scholar
  10. Pedarzani, P. et al. J. Biol. Chem. 276, 9762–9769 (2001).
    Article CAS Google Scholar
  11. Schumacher, M. & Adelman, J.P. Nature 417, 501–502 (2002).
    Article CAS Google Scholar
  12. Tacconi, S. et al. Neuroscience 102, 209–215 (2001).
    Article CAS Google Scholar
  13. Moore, C.I., Browning, M.D. & Rose, G.M. Hippocampus 3, 57–66 (1993).
    Article CAS Google Scholar
  14. Lanahan, A., Lyford, G., Stevenson, G.S., Worley, P.F. & Barnes, C.A. J. Neurosci. 17, 2876–2885 (1997).
    Article CAS Google Scholar
  15. Blank, T., Nijholt, I., Eckart, K. & Spiess, J. J. Neurosci. 22, 3788–3794 (2002).
    Article CAS Google Scholar

Download references

Acknowledgements

This work was supported by the Max Planck Society. We thank Dr. John Disterhoft for fruitful discussions and his generous support in obtaining the animals for this study.

Author information

Authors and Affiliations

  1. Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, D-37075, Germany
    Thomas Blank, Ingrid Nijholt, Min-Jeong Kye, Jelena Radulovic & Joachim Spiess

Authors

  1. Thomas Blank
    You can also search for this author inPubMed Google Scholar
  2. Ingrid Nijholt
    You can also search for this author inPubMed Google Scholar
  3. Min-Jeong Kye
    You can also search for this author inPubMed Google Scholar
  4. Jelena Radulovic
    You can also search for this author inPubMed Google Scholar
  5. Joachim Spiess
    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toThomas Blank.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

About this article

Cite this article

Blank, T., Nijholt, I., Kye, MJ. et al. Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.Nat Neurosci 6, 911–912 (2003). https://doi.org/10.1038/nn1101

Download citation