Regulation of gene expression and cocaine reward by CREB and ΔFosB (original) (raw)
Nestler, E.J. Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci.2, 119–128 (2001). ArticleCAS Google Scholar
Berke, J.D. & Hyman, S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron25, 515–532 (2000). ArticleCAS Google Scholar
Mayr, B. & Montminy, M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol.2, 599–609 (2001). ArticleCAS Google Scholar
Lonze, B.E. & Ginty, D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron35, 605–623 (2002). ArticleCAS Google Scholar
Yin, J.C. & Tully, T. CREB and the formation of long-term memory. Curr. Opin. Neurobiol.6, 264–268 (1996). ArticleCAS Google Scholar
Mayford, M. & Kandel, E.R. Genetic approaches to memory storage. Trends Genet.15, 463–470 (1999). ArticleCAS Google Scholar
Impey, S. et al. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat. Neurosci.1, 595–601 (1998). ArticleCAS Google Scholar
Duman, R.S. Synaptic plasticity and mood disorders. Mol. Psychiatry7 (Suppl.) S29–34 (2002). ArticleCAS Google Scholar
Barrot, M. et al. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA99, 11435–11440 (2002). ArticleCAS Google Scholar
Terwilliger, R.Z., Beitner-Johnson, D., Sevarino, K.A., Crain, S.M. & Nestler, E.J. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res.548, 100–110 (1991). ArticleCAS Google Scholar
Unterwald, E.M., Cox, B.M., Kreek, M.J., Cote, T.E. & Izenwasser, S. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse15, 33–38 (1993). ArticleCAS Google Scholar
Turgeon, S.M., Pollack, A.E. & Fink, J.S. Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization. Brain Res.749, 120–126 (1997). ArticleCAS Google Scholar
Cole, R.L., Konradi, C., Douglass, J. & Hyman, S.E. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron14, 813–823 (1995). ArticleCAS Google Scholar
Self, D.W. et al. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J. Neurosci.18, 1848–1859 (1998). ArticleCAS Google Scholar
Carlezon, W.A. et al. Regulation of cocaine reward by CREB. Science282, 2272–2275 (1998). ArticleCAS Google Scholar
Pliakas, A.M. et al. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element binding protein expression in the nucleus accumbens. J. Neurosci.21, 7397–7403 (2001). ArticleCAS Google Scholar
Walters, C.L. & Blendy, J.A. Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. J. Neurosci.21, 9438–9444 (2001). ArticleCAS Google Scholar
Hope, B.T. et al. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron13, 1235–1244 (1994). ArticleCAS Google Scholar
Moratalla, R., Elibol, B., Vallejo, M. & Graybiel, A.M. Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron17, 147–156 (1996). ArticleCAS Google Scholar
Chen, J., Kelz, M.B., Hope, B.T., Nakabeppu, Y. & Nestler, E.J. Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J. Neurosci.17, 4933–4491 (1997). ArticleCAS Google Scholar
Nestler, E.J., Barrot, M. & Self, D.W. DeltaFosB: a sustained molecular switch for addiction. Proc. Natl. Acad. Sci. USA98, 11042–11046 (2001). ArticleCAS Google Scholar
Kelz, M.B. et al. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature401, 272–276 (1999). ArticleCAS Google Scholar
Colby, C.R., Whisler, K., Steffen, C., Nestler, E.J. & Self, D.W. Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J. Neurosci.23, 2488–2493 (2003). ArticleCAS Google Scholar
Peakman, M.C. et al. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res.970, 73–86 (2003). ArticleCAS Google Scholar
Ehrlich, M.E., Sommer, J., Canas, E. & Unterwald, E.M. Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine. J. Neurosci.22, 9155–9159 (2002). ArticleCAS Google Scholar
Simpson, J.N. & McGinty, J.F. Forskolin induces proenkephalin and preprodynorphin mRNA in rat striatum as demonstrated by in situ hybridization histochemistry. Synapse19, 151–159 (1995). ArticleCAS Google Scholar
Andersson, M., Konradi, C. & Cenci, M.A. cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum. J. Neurosci.21, 9930–9943 (2001). ArticleCAS Google Scholar
Ang, E. et al. Induction of nuclear factor-κB in nucleus accumbens by chronic cocaine administration. J. Neurochem.79, 221–224 (2001). ArticleCAS Google Scholar
Bibb, J.A. et al. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature410, 376–380 (2001). ArticleCAS Google Scholar
Chen, J. et al. Transgenic animals with inducible, targeted gene expression in the brain. Mol. Pharmacol.54, 495–503 (1998). ArticleCAS Google Scholar
Sakai, N. et al. Inducible and brain region-specific CREB transgenic mice. Mol. Pharmacol.61, 1453–1464 (2002). ArticleCAS Google Scholar
Newton, S.S. et al. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J. Neurosci.22, 10883–10890 (2002). ArticleCAS Google Scholar
Shaw-Lutchman, S.Z., Impey, S., Storm, D. & Nestler, E.J. Regulation of CRE-mediated transcription in mouse brain by amphetamine. Synapse8, 10–17 (2003). Article Google Scholar
Lloyd, A., Yancheva, N. & Wasylyk, B. Transformation suppressor activity of a Jun transcription factor lacking its activation domain. Nature352, 635–638 (1991). ArticleCAS Google Scholar
Brown, P.H., Kim, S.H., Wise, S.C., Sabichi, A.L. & Birrer, M.J. Dominant-negative mutants of cJun inhibit AP-1 activity through multiple mechanisms and with different potencies. Cell Growth Differ.7, 1013–1021 (1996). CASPubMed Google Scholar
Nakabeppu, Y. & Nathans, D. A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. Cell64, 751–759 (1991). ArticleCAS Google Scholar
Yen, J., Wisdom, R.M., Tratner, I. & Verma, I.M. An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins. Proc. Natl. Acad. Sci. USA88, 5077–5081 (1991). ArticleCAS Google Scholar
Dobrazanski, P. et al. Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts. Mol. Cell Biol.11, 5470–5478 (1991). ArticleCAS Google Scholar
Chen, J. et al. Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of deltaFosB. J. Neurosci.20, 8965–8971 (2000). ArticleCAS Google Scholar
Wu, X. & McMurray, C.T. Calmodulin kinase II attenuation of gene transcription by preventing cAMP response-element binding protein (CREB) dimerization and binding of the CREB-binding protein. J. Biol. Chem.276, 1735–1741 (2001). ArticleCAS Google Scholar
Korutla, L. et al. Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1. Neuroscience110, 421–429 (2002). ArticleCAS Google Scholar
Bannon, M.J. et al. Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers. Proc. Natl. Acad. Sci. USA99, 6382–6385 (2002). ArticleCAS Google Scholar
O'Donovan, K.J., Tourtellotte, W.G., Millbrandt, J. & Baraban J.M. The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci.22, 167–173 (1999). ArticleCAS Google Scholar
Yuferov, V. et al. Differential gene expression in the rat caudate putamen after “binge” cocaine administration: advantage of triplicate microarray analysis. Synapse48, 157–169 (2003). ArticleCAS Google Scholar
Freeman, W.M. et al. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. J. Neurochem.77, 542–549 (2001). ArticleCAS Google Scholar
Beinfeld, M.C., Connolly, K.J. & Pierce, R.C. Cocaine treatment increase extracellular cholecystokinin (CCK) in the nucleus accumbens shell of awake, freely moving rats, an effect that is enhanced in rats that are behaviorally sensitized to cocaine. J. Neurochem.81, 1021–1027 (2002). ArticleCAS Google Scholar
Tanganelli, S., Fuxe, K., Antonelli, T., O'Connor, W.T. & Ferraro, L. Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates. Peptides22, 1229–1234 (2001). ArticleCAS Google Scholar
Josselyn, S.A., Franco, V.P. & Vaccarino, F.J. PD-135158, A CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior. Neurosci. Lett.209, 85–88 (1996). ArticleCAS Google Scholar
Beurrier, C. & Malenka, R.C. Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine. J. Neurosci.22, 5817–5822 (2002). ArticleCAS Google Scholar