Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis (original) (raw)
Haass, C. & Steiner, H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders? Nat. Neurosci.4, 859–860 (2001). ArticleCAS Google Scholar
Hardy, J. Amyloid, the presenilins and Alzheimer's disease. Trends. Neurosci.20, 154–159 (1997). ArticleCAS Google Scholar
Selkoe, D.J. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature399, A23–31 (1999). ArticleCAS Google Scholar
Levy, E. et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science248, 1124–1126 (1990). ArticleCAS Google Scholar
Wattendorff, A.R., Bots, G.T., Went, L.N. & Endtz, L.J. Familial cerebral amyloid angiopathy presenting as recurrent cerebral haemorrhage. J. Neurol. Sci.55, 121–135 (1982). ArticleCAS Google Scholar
Bornebroek, M., Haan, J., Maat-Schieman, M.L., Van Duinen, S.G. & Roos, R.A. Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). I. A review of clinical, radiologic and genetic aspects. Brain. Pathol.6, 111–114 (1996). ArticleCAS Google Scholar
Maat-Schieman, M.L., van Duinen, S.G., Bornebroek, M., Haan, J. & Roos, R.A. Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). II. A review of histopathological aspects. Brain. Pathol.6, 115–120 (1996). ArticleCAS Google Scholar
Vinters, H.V. Cerebral amyloid angiopathy. A critical review. Stroke18, 311–324 (1987). ArticleCAS Google Scholar
Greenberg, S.M. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology51, 690–694 (1998). ArticleCAS Google Scholar
Fraser, P.E. et al. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid β-protein. Biochemistry31, 10716–10723 (1992). ArticleCAS Google Scholar
De Jonghe, C. et al. Flemish and Dutch mutations in amyloid β precursor protein have different effects on amyloid β secretion. Neurobiol. Dis.5, 281–286 (1998). ArticleCAS Google Scholar
Watson, D.J., Selkoe, D.J. & Teplow, D.B. Effects of the amyloid precursor protein Glu693ÆGln 'Dutch' mutation on the production and stability of amyloid β-protein. Biochem. J.340 (Pt 3), 703–709 (1999). ArticleCAS Google Scholar
Monro, O.R. et al. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-β peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol. Aging23, 405–412 (2002). ArticleCAS Google Scholar
Van Nostrand, W.E., Melchor, J.P. & Ruffini, L. Pathologic amyloid β-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells. J. Neurochem.70, 216–223 (1998). ArticleCAS Google Scholar
Klafki, H.W., Wiltfang, J. & Staufenbiel, M. Electrophoretic separation of βA4 peptides (1–40) and (1–42). Anal. Biochem.237, 24–29 (1996). ArticleCAS Google Scholar
Citron, M. et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med.3, 67–72 (1997). ArticleCAS Google Scholar
De Jonghe, C. et al. Evidence that Aβ42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype. Neurobiol. Dis.6, 280–287 (1999). ArticleCAS Google Scholar
Castano, E.M. et al. The length of amyloid-β in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-β 1–42 in Alzheimer's disease. J. Biol. Chem.271, 32185–32191 (1996). ArticleCAS Google Scholar
Prelli, F. et al. Expression of a normal and variant Alzheimer's β-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays. Biochem. Biophys. Res. Commun.170, 301–307 (1990). ArticleCAS Google Scholar
Jankowsky, J.L. et al. Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase. Hum. Mol. Genet.13, 159–170 (2004). ArticleCAS Google Scholar
Johnson-Wood, K. et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA94, 1550–1555 (1997). ArticleCAS Google Scholar
Richards, J.G. et al. PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J. Neurosci.23, 8989–9003 (2003). ArticleCAS Google Scholar
Hsiao, K. et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science274, 99–102 (1996). ArticleCAS Google Scholar
Nilsberth, C. et al. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation. Nat. Neurosci.4, 887–893 (2001). ArticleCAS Google Scholar
Tsubuki, S., Takaki, Y. & Saido, T.C. Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Aβ to physiologically relevant proteolytic degradation. Lancet361, 1957–1958 (2003). ArticleCAS Google Scholar
Morelli, L. et al. Differential degradation of amyloid β genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme. J. Biol. Chem.278, 23221–23226 (2003). ArticleCAS Google Scholar
Borchelt, D.R. et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron19, 939–945 (1997). ArticleCAS Google Scholar
Holcomb, L. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med.4, 97–100 (1998). ArticleCAS Google Scholar
Natte, R. et al. Ultrastructural evidence of early non-fibrillar Aβ42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type. Acta Neuropathol. (Berl.)98, 577–582 (1999). ArticleCAS Google Scholar
Meyer-Luehmann, M. et al. Extracellular amyloid formation and associated pathology in neural grafts. Nat. Neurosci.6, 370–377 (2003). ArticleCAS Google Scholar
Shibata, M. et al. Clearance of Alzheimer's amyloid-β(1–40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest.106, 1489–1499 (2000). ArticleCAS Google Scholar
Weller, R.O. et al. Cerebral amyloid angiopathy: amyloid β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am. J. Pathol.153, 725–733 (1998). ArticleCAS Google Scholar
Pfeifer, M. et al. Cerebral hemorrhage after passive anti-Aβ immunotherapy. Science298, 1379 (2002). ArticleCAS Google Scholar
Das, P., Murphy, M.P., Younkin, L.H., Younkin, S.G. & Golde, T.E. Reduced effectiveness of Aβ1–42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol. Aging22, 721–727 (2001). ArticleCAS Google Scholar
Nicoll, J.A. et al. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report. Nat. Med.9, 448–452 (2003). ArticleCAS Google Scholar
Koller, M.F. et al. Active immunization of mice with an Aβ-Hsp70 vaccine. Neurodegenerative Dis.1, 20–28 (2004). ArticleCAS Google Scholar
Ferrer, I., Boada Rovira, M., Sánchez Guerra, M.L., Rey, M.J. & Costa-Jussá, F. Neuropathology and pathogenesis of encephalitis following amyloid-β immunization in Alzheimer's disease. Brain Pathol.14, 11–20 (2004). ArticleCAS Google Scholar
Natte, R. et al. Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. Ann. Neurol.50, 765–772 (2001). ArticleCAS Google Scholar
Greenberg, S.M. Cerebral amyloid angiopathy and dementia: two amyloids are worse than one. Neurology58, 1587–1588 (2002). Article Google Scholar
Christie, R., Yamada, M., Moskowitz, M. & Hyman, B. Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy. Am. J. Pathol.158, 1065–1071 (2001). ArticleCAS Google Scholar
Winkler, D.T. et al. Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. J. Neurosci.21, 1619–1627 (2001). ArticleCAS Google Scholar
Calhoun, M.E. et al. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc. Natl. Acad. Sci. USA96, 14088–14093 (1999). ArticleCAS Google Scholar
Van Dorpe, J. et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons. Am. J. Pathol.157, 1283–1298 (2000). ArticleCAS Google Scholar
Sturchler-Pierrat, C. et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. USA94, 13287–13292 (1997). ArticleCAS Google Scholar
Bodendorf, U. et al. Expression of human β-secretase in the mouse brain increases the steady-state level of β-amyloid. J. Neurochem.80, 799–806 (2002). ArticleCAS Google Scholar
Mehta, P.D. et al. Plasma and cerebrospinal fluid levels of amyloid β proteins 1–40 and 1–42 in Alzheimer disease. Arch. Neurol.57, 100–105 (2000). ArticleCAS Google Scholar
Ohsawa, K., Imai, Y., Kanazawa, H., Sasaki, Y. & Kohsaka, S. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J. Cell. Sci.113 (Pt 17), 3073–3084 (2000). CASPubMed Google Scholar
Janus, C. et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature408, 979–982 (2000). ArticleCAS Google Scholar
Rozmahel, R. et al. Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP. Neurobiol. Aging23, 187–194 (2002). ArticleCAS Google Scholar
Maat-Schieman, M.L., Yamaguchi, H., van Duinen, S.G., Natte, R. & Roos, R.A. Age-related plaque morphology and C-terminal heterogeneity of amyloid β in Dutch-type hereditary cerebral hemorrhage with amyloidosis. Acta Neuropathol. (Berl.)99, 409–419 (2000). ArticleCAS Google Scholar