Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine (original) (raw)

Nature Neuroscience volume 8, pages 858–859 (2005)Cite this article

Abstract

Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg−1 increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors.

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Acknowledgements

This study was supported in part by grants-in-aid for scientific research from the Japan Society for the Promotion of Science (O.H., Z.-L.H.), the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN; Y.U.), Takeda Pharmaceutical Company Limited (O.H.) and Osaka City. This manuscript is dedicated to the late S. Fink to acknowledge his many scientific contributions to adenosine studies.

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Authors and Affiliations

  1. Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, 565-0874, Japan
    Zhi-Li Huang, Wei-Min Qu, Naomi Eguchi, Yoshihiro Urade & Osamu Hayaishi
  2. Department of Neurology, Boston University School of Medicine, Boston, 02118, Massachusetts, USA
    Jiang-Fan Chen
  3. Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston, 02129, Massachusetts, USA
    Michael A Schwarzschild
  4. Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, S-17177, Sweden
    Bertil B Fredholm

Authors

  1. Zhi-Li Huang
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  2. Wei-Min Qu
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  3. Naomi Eguchi
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  4. Jiang-Fan Chen
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  5. Michael A Schwarzschild
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  6. Bertil B Fredholm
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  7. Yoshihiro Urade
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  8. Osamu Hayaishi
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Correspondence toOsamu Hayaishi.

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Huang, ZL., Qu, WM., Eguchi, N. et al. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.Nat Neurosci 8, 858–859 (2005). https://doi.org/10.1038/nn1491

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