CREB modulates excitability of nucleus accumbens neurons (original) (raw)

Nature Neuroscience volume 9, pages 475–477 (2006)Cite this article

Abstract

Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.

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Acknowledgements

We thank E. Sura and W. Ju for technical assistance and J. Trimmer, R.C. Yu and R. Axel for providing constructs. This work was supported by grants from the National Institute on Drug Abuse and the US National Institute of Mental Health.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University, Palo Alto, 94304, California, USA
    Yan Dong, Daniel Saal, Helene Marie & Robert C Malenka
  2. Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, 75390, Texas, USA
    Thomas Green & Eric J Nestler
  3. Department of Genetics and McClean Hospital, Harvard University, Cambridge, 02478, Massachusetts, USA
    Rachael Neve

Authors

  1. Yan Dong
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  2. Thomas Green
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  3. Daniel Saal
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  4. Helene Marie
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  5. Rachael Neve
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  6. Eric J Nestler
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  7. Robert C Malenka
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Correspondence toRobert C Malenka.

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Dong, Y., Green, T., Saal, D. et al. CREB modulates excitability of nucleus accumbens neurons.Nat Neurosci 9, 475–477 (2006). https://doi.org/10.1038/nn1661

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