Neuronal activity determines the protein synthesis dependence of long-term potentiation (original) (raw)

Nature Neuroscience volume 9, pages 478–480 (2006)Cite this article

Abstract

Long-term potentiation (LTP) is generally divided into two phases, early (E-) and late (L-) LTP, of which only L-LTP is thought to depend on protein synthesis. Here we report that E-LTP can also be dependent on protein synthesis at higher levels of synaptic activation. Moreover, we show that the requirement for protein synthesis during L-LTP extends beyond the early induction phase and that it depends on synaptic stimulation. This suggests that the level of neuronal activity is a crucial determinant for the role of protein synthesis in E- and L-LTP.

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Acknowledgements

We thank R. Morris, R. Redondo and T. Mrsic-Flogel for comments on the manuscript. Funding was provided by the Max Planck Society (R.F., U.V.N. and T.B.), the National Research Council of Portugal (R.F.) and the Human Frontier Science Program (R.F. and T.B.).

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Authors and Affiliations

  1. Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, München-Martinsried, D-82152, Germany
    Rosalina Fonseca, U Valentin Nägerl & Tobias Bonhoeffer

Authors

  1. Rosalina Fonseca
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  2. U Valentin Nägerl
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  3. Tobias Bonhoeffer
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Correspondence toTobias Bonhoeffer.

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Fonseca, R., Nägerl, U. & Bonhoeffer, T. Neuronal activity determines the protein synthesis dependence of long-term potentiation.Nat Neurosci 9, 478–480 (2006). https://doi.org/10.1038/nn1667

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