Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation (original) (raw)

Nature Neuroscience volume 9, pages 602–604 (2006)Cite this article

Abstract

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs ∼25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

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Acknowledgements

Supported by the Wellcome Trust (A.T., G.L.C. and J.T.R.I.), the Medical Research Council UK (G.L.C. and J.T.R.I.), the National Institute of Neurological Disorders and Stroke Intramural Program (J.T.R.I.) and the National Institute of Child Health and Human Development Intramural Program (K.A.P. and C.J.M.)

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Author notes

  1. Karen Plant and Kenneth A Pelkey: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, Bristol, BS8 1TD, UK
    Karen Plant, Zuner A Bortolotto, Daiju Morita, Akira Terashima, Graham L Collingridge & John T R Isaac
  2. Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, 35 Convent Drive, Bethesda, 20892, Maryland, USA
    Kenneth A Pelkey & Chris J McBain
  3. Developmental Synaptic Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, 20892, Maryland, USA
    Daiju Morita & John T R Isaac

Authors

  1. Karen Plant
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  2. Kenneth A Pelkey
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  3. Zuner A Bortolotto
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  4. Daiju Morita
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  5. Akira Terashima
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  6. Chris J McBain
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  7. Graham L Collingridge
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  8. John T R Isaac
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Correspondence toJohn T R Isaac.

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The authors declare no competing financial interests.

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Plant, K., Pelkey, K., Bortolotto, Z. et al. Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation.Nat Neurosci 9, 602–604 (2006). https://doi.org/10.1038/nn1678

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