Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic (original) (raw)

• Kessler, R.C., Chiu, W.T., Demler, O., Merikangas, K.R. & Walters, E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 617–627 (2005).
  PubMed PubMed Central Google Scholar
• Keller, M.B. et al. Time to recovery, chronicity, and levels of psychopathology in major depression. A 5-year prospective follow-up of 431 subjects. Arch. Gen. Psychiatry 49, 809–816 (1992).
  CAS PubMed Google Scholar
• Greenberg, P. et al. The economic burden of anxiety disorders in the 1990s. J. Clin. Psychiatry 60, 427–435 (1999).
  CAS PubMed Google Scholar
• Gorman, J.M. Comorbid depression and anxiety spectrum disorders. Depress. Anxiety 4, 160–168 (1996).
  PubMed Google Scholar
• Ressler, K.J. & Nemeroff, C.B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress. Anxiety 12, 2–19 (2000).
  PubMed Google Scholar
• Berton, O. et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311, 864–868 (2006).
  Article CAS PubMed Google Scholar
• Bornstein, S.R., Schuppenies, A., Wong, M.L. & Licinio, J. Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions. Mol. Psychiatry 11, 892–902 (2006).
  CAS PubMed Google Scholar
• Nestler, E.J. & Carlezon, W.A., Jr. The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 59, 1151–1159 (2006).
  CAS PubMed Google Scholar
• Tremblay, L.K. et al. Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch. Gen. Psychiatry 62, 1228–1236 (2005).
  PubMed Google Scholar
• Schlaepfer, T.E. et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology, advance online publication 11 April 2007 (doi: 10.1038/sj.npp.1301408).
  PubMed Google Scholar
• Mayberg, H.S. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br. Med. Bull. 65, 193–207 (2003).
  PubMed Google Scholar
• Mayberg, H.S. et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am. J. Psychiatry 156, 675–682 (1999).
  CAS PubMed Google Scholar
• Drevets, W.C. Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog. Brain Res. 126, 413–431 (2000).
  CAS PubMed Google Scholar
• Milad, M.R. et al. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol. Psychiatry, published online 9 January 2007 (doi:10.1016/j.biopsych.2006.10.011).
  PubMed Google Scholar
• Siegle, G.J., Carter, C.S. & Thase, M.E. Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy. Am. J. Psychiatry 163, 735–738 (2006).
  PubMed Google Scholar
• Furmark, T. et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch. Gen. Psychiatry 59, 425–433 (2002).
  PubMed Google Scholar
• Drevets, W.C. Neuroimaging studies of mood disorders. Biol. Psychiatry 48, 813–829 (2000).
  CAS PubMed Google Scholar
• Canli, T. & Lesch, K.-P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 10, 1103–1109 (2007).
  CAS PubMed Google Scholar
• Pezawas, L. et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat. Neurosci. 8, 828–834 (2005).
  CAS PubMed Google Scholar
• George, M.S. et al. Vagus nerve stimulation for the treatment of depression and other neuropsychiatric disorders. Expert Rev. Neurother. 7, 63–74 (2007).
  PubMed Google Scholar
• Henry, T.R. et al. Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: I. Acute effects at high and low levels of stimulation. Epilepsia 39, 983–990 (1998).
  CAS PubMed Google Scholar
• Ben-Menachem, E. et al. Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures. Epilepsy Res. 20, 221–227 (1995).
  CAS PubMed Google Scholar
• Krahl, S.E., Senanayake, S.S. & Handforth, A. Seizure suppression by systemic epinephrine is mediated by the vagus nerve. Epilepsy Res. 38, 171–175 (2000).
  CAS PubMed Google Scholar
• Walker, B.R., Easton, A. & Gale, K. Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. Epilepsia 40, 1051–1057 (1999).
  CAS PubMed Google Scholar
• Craig, A.D. How do you feel? Interoception: the sense of the physiological condition of the body. Nat. Rev. Neurosci. 3, 655–666 (2002).
  CAS PubMed Google Scholar
• Henry, T.R. Therapeutic mechanisms of vagus nerve stimulation. Neurology 59, S3–S14 (2002).
  PubMed Google Scholar
• Cox, C.L., Huguenard, J.R. & Prince, D.A. Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus. Proc. Natl. Acad. Sci. USA 94, 8854–8859 (1997).
  CAS PubMed PubMed Central Google Scholar
• Malow, B.A. et al. Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients. Neurology 57, 879–884 (2001).
  CAS PubMed Google Scholar
• Zobel, A. et al. Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: an exploratory approach. Psychiatry Res. 139, 165–179 (2005).
  PubMed Google Scholar
• Bohning, D.E. et al. Feasibility of vagus nerve stimulation-synchronized blood oxygenation level-dependent functional MRI. Invest. Radiol. 36, 470–479 (2001).
  CAS PubMed Google Scholar
• Nahas, Z. et al. Serial vagus nerve stimulation functional MRI in treatment-resistant depression. Neuropsychopharmacology, 32, 1649–1660 (2007).
  CAS Google Scholar
• Sackeim, H.A. et al. Durability of antidepressant response to vagus nerve stimulation (VNSTM). Int. J. Neuropsychopharmacol., published online 9 February 2007 (doi:10.1017/S1461145706007425).
• Lisanby, S.H. et al. New developments in electroconvulsive therapy and magnetic seizure therapy. CNS Spectr. 8, 529–536 (2003).
  PubMed Google Scholar
• Sackeim, H.A. et al. Cognitive consequences of low-dosage electroconvulsive therapy. Ann. NY Acad. Sci. 462, 326–340 (1986).
  CAS PubMed Google Scholar
• Carpenter, L.L. Neurostimulation in resistant depression. J. Psychopharmacol. 20, 35–40 (2006).
  PubMed Google Scholar
• Epstein, C.M., Schwartzberg, D.G., Davey, K.R. & Sudderth, D.B. Localizing the site of magnetic brain stimulation in humans. Neurology 40, 666–670 (1990).
  CAS PubMed Google Scholar
• Barker, A.T., Jalinous, R. & Freeston, I.L. Non-invasive magnetic stimulation of human motor cortex. Lancet 1, 1106–1107 (1985).
  CAS PubMed Google Scholar
• Paus, T. & Barrett, J. Transcranial magnetic stimulation (TMS) of the human frontal cortex: implications for repetitive TMS treatment of depression. J. Psychiatry Neurosci. 29, 268–279 (2004).
  PubMed PubMed Central Google Scholar
• Pascual-Leone, A., Rubio, B., Pallardo, F. & Catala, M.D. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 348, 233–237 (1996).
  CAS PubMed Google Scholar
• George, M.S. et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial. Am. J. Psychiatry 154, 1752–1756 (1997).
  CAS PubMed Google Scholar
• Herrmann, L.L. & Ebmeier, K.P. Factors modifying the efficacy of transcranial magnetic stimulation in the treatment of depression: a review. J. Clin. Psychiatry 67, 1870–1876 (2006).
  PubMed Google Scholar
• Couturier, J.L. Efficacy of rapid-rate repetitive transcranial magnetic stimulation in the treatment of depression: a systematic review and meta-analysis. J. Psychiatry Neurosci. 30, 83–90 (2005).
  PubMed PubMed Central Google Scholar
• O'Reardon, J.P. et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol. Psychiatry, published online 14 June 2007 (doi:10.1016/j.biopsych.2007.01.018).
  PubMed Google Scholar
• Bohning, D.E. et al. Mapping transcranial magnetic stimulation (TMS) fields in vivo with MRI. Neuroreport 8, 2535–2538 (1997).
  CAS PubMed Google Scholar
• Kimbrell, T.A. et al. Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol. Psychiatry 46, 1603–1613 (1999).
  CAS PubMed Google Scholar
• Speer, A.M. et al. Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol. Psychiatry 48, 1133–1141 (2000).
  CAS PubMed Google Scholar
• Kim, E.J. et al. Repetitive transcranial magnetic stimulation protects hippocampal plasticity in an animal model of depression. Neurosci. Lett. 405, 79–83 (2006).
  CAS PubMed Google Scholar
• Kosel, M., Frick, C., Lisanby, S.H., Fisch, H.U. & Schlaepfer, T.E. Magnetic seizure therapy improves mood in refractory major depression. Neuropsychopharmacology 28, 2045–2048 (2003).
  PubMed Google Scholar
• Benabid, A.L. Deep brain stimulation for Parkinson's disease. Curr. Opin. Neurobiol. 13, 696–706 (2003).
  CAS PubMed Google Scholar
• Bejjani, B.P. et al. Transient acute depression induced by high-frequency deep-brain stimulation. N. Engl. J. Med. 340, 1476–1480 (1999).
  CAS PubMed Google Scholar
• Kopell, B.H., Greenberg, B. & Rezai, A.R. Deep brain stimulation for psychiatric disorders. J. Clin. Neurophysiol. 21, 51–67 (2004).
  PubMed Google Scholar
• Aouizerate, B. et al. Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression. Case report. J. Neurosurg. 101, 682–686 (2004).
  PubMed Google Scholar
• Brody, A.L. et al. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Arch. Gen. Psychiatry 58, 631–640 (2001).
  CAS PubMed Google Scholar
• Seminowicz, D.A. et al. Limbic-frontal circuitry in major depression: a path modeling metanalysis. Neuroimage 22, 409–418 (2004).
  CAS PubMed Google Scholar
• Dougherty, D.D. et al. Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression. J. Neurosurg. 99, 1010–1017 (2003).
  PubMed Google Scholar
• Goldapple, K. et al. Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. Arch. Gen. Psychiatry 61, 34–41 (2004).
  PubMed Google Scholar
• Nobler, M.S. et al. Structural and functional neuroimaging of electroconvulsive therapy and transcranial magnetic stimulation. Depress. Anxiety 12, 144–156 (2000).
  CAS PubMed Google Scholar
• Mayberg, H.S. et al. Deep brain stimulation for treatment-resistant depression. Neuron 45, 651–660 (2005).
  CAS PubMed Google Scholar
• Davis, K.D. et al. Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms. Nat. Med. 3, 671–674 (1997).
  CAS PubMed Google Scholar
• Lozano, A.M., Dostrovsky, J., Chen, R. & Ashby, P. Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neurol. 1, 225–231 (2002).
  PubMed Google Scholar
• McIntyre, C.C., Savasta, M., Kerkerian-Le Goff, L. & Vitek, J.L. Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. Clin. Neurophysiol. 115, 1239–1248 (2004).
  PubMed Google Scholar
• Harbishettar, V., Pal, P.K., Janardhan Reddy, Y.C. & Thennarasu, K. Is there a relationship between Parkinson's disease and obsessive-compulsive disorder? Parkinsonism Relat. Disord. 11, 85–88 (2005).
  PubMed Google Scholar
• Nuttin, B., Cosyns, P., Demeulemeester, H., Gybels, J. & Meyerson, B. Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder. Lancet 354, 1526 (1999).
  CAS PubMed Google Scholar
• Greenberg, B.D. et al. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 31, 2384–2393 (2006).
  PubMed Google Scholar
• Pitman, R.K. & Delahanty, D.L. Conceptually driven pharmacologic approaches to acute trauma. CNS Spectr. 10, 99–106 (2005).
  PubMed Google Scholar
• Rothbaum, B.O. & Davis, M. Applying learning principles to the treatment of post-trauma reactions. Ann. NY Acad. Sci. 1008, 112–121 (2003).
  PubMed Google Scholar
• Myers, K.M. & Davis, M. Behavioral and neural analysis of extinction. Neuron 36, 567–584 (2002).
  CAS PubMed Google Scholar
• Walker, D.L., Ressler, K.J., Lu, K.T. & Davis, M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear- potentiated startle in rats. J. Neurosci. 22, 2343–2351 (2002).
  CAS PubMed PubMed Central Google Scholar
• Monahan, J.B., Handelmann, G.E., Hood, W.F. & Cordi, A.A. D-cycloserine, a positive modulator of the _N_-methyl-D-aspartate receptor, enhances performance of learning tasks in rats. Pharmacol. Biochem. Behav. 34, 649–653 (1989).
  CAS PubMed Google Scholar
• Lee, J.L., Milton, A.L. & Everitt, B.J. Reconsolidation and extinction of conditioned fear: inhibition and potentiation. J. Neurosci. 26, 10051–10056 (2006).
  CAS PubMed PubMed Central Google Scholar
• Botreau, F., Paolone, G. & Stewart, J. D-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference. Behav. Brain Res. 172, 173–178 (2006).
  CAS PubMed Google Scholar
• Ledgerwood, L., Richardson, R. & Cranney, J. Effects of D-cycloserine on extinction of conditioned freezing. Behav. Neurosci. 117, 341–349 (2003).
  CAS PubMed Google Scholar
• Yang, Y.L. & Lu, K.T. Facilitation of conditioned fear extinction by D-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala. Neuroscience 134, 247–260 (2005).
  CAS PubMed Google Scholar
• Otto, M. Learning and “unlearning” fears: preparedness, neural pathways, and patients. Biol. Psychiatry 52, 917–920 (2002).
  PubMed Google Scholar
• Ressler, K.J. et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch. Gen. Psychiatry 61, 1136–1144 (2004).
  PubMed Google Scholar
• Hofmann, S.G. et al. Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Arch. Gen. Psychiatry 63, 298–304 (2006).
  CAS PubMed Google Scholar
• Kushner, M.G. et al. D-Cycloserine augmented exposure therapy for obsessive compulsive disorder. Biol. Psychiatry, published online 22 June 2007 (doi:10.1016/j.biopsych.2006.12.020).
  CAS PubMed Google Scholar
• Guastella, A.J., Dadds, M.R., Lovibond, P.F., Mitchell, P. & Richardson, R. A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear. J. Psychiatr. Res. 41, 466–471 (2007).
  PubMed Google Scholar
• Guastella, A.J., Lovibond, P.F., Dadds, M.R., Mitchell, P. & Richardson, R. A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans. Behav. Res. Ther. 45, 663–672 (2007).
  PubMed Google Scholar
• McGaugh, J.L. Memory–a century of consolidation. Science 287, 248–251 (2000).
  CAS PubMed Google Scholar
• Ferry, B., Roozendaal, B. & McGaugh, J.L. Basolateral amygdala noradrenergic influences on memory storage are mediated by an interaction between β- and α1-adrenoceptors. J. Neurosci. 19, 5119–5123 (1999).
  CAS PubMed PubMed Central Google Scholar
• Quirarte, G.L., Roozendaal, B. & McGaugh, J.L. Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala. Proc. Natl. Acad. Sci. USA 94, 14048–14053 (1997).
  CAS PubMed PubMed Central Google Scholar
• Pitman, R.K. et al. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol. Psychiatry 51, 189–192 (2002).
  CAS PubMed Google Scholar
• Vaiva, G. et al. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol. Psychiatry 54, 947–949 (2003).
  CAS PubMed Google Scholar
• Yehuda, R. et al. Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder. Am. J. Psychiatry 152, 982–986 (1995).
  CAS PubMed Google Scholar
• Yehuda, R., Golier, J.A., Yang, R.K. & Tischler, L. Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol. Psychiatry 55, 1110–1116 (2004).
  CAS PubMed Google Scholar
• Borrell, J., De Kloet, E.R., Versteeg, D.H. & Bohus, B. Inhibitory avoidance deficit following short-term adrenalectomy in the rat: the role of adrenal catecholamines. Behav. Neural Biol. 39, 241–258 (1983).
  CAS PubMed Google Scholar
• Schelling, G. et al. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol. Psychiatry 50, 978–985 (2001).
  CAS PubMed Google Scholar
• Cai, W.H., Blundell, J., Han, J., Greene, R.W. & Powell, C.M. Postreactivation glucocorticoids impair recall of established fear memory. J. Neurosci. 26, 9560–9566 (2006).
  CAS PubMed PubMed Central Google Scholar
• Tronel, S. & Alberini, C.M. Persistent disruption of a traumatic memory by postretrieval inactivation of glucocorticoid receptors in the amygdala. Biol. Psychiatry 62, 33–39 (2007).
  CAS PubMed PubMed Central Google Scholar
• Schafe, G.E., Nader, K., Blair, H.T. & LeDoux, J.E. Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective. Trends Neurosci. 24, 540–546 (2001).
  CAS PubMed Google Scholar
• Guarraci, F.A., Frohardt, R.J., Falls, W.A. & Kapp, B.S. The effects of intra-amygdaloid infusions of a D2 dopamine receptor antagonist on Pavlovian fear conditioning. Behav. Neurosci. 114, 647–651 (2000).
  CAS PubMed Google Scholar
• Shimizu, E., Tang, Y.P., Rampon, C. & Tsien, J.Z. NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science 290, 1170–1174 (2000).
  CAS PubMed Google Scholar
• Nader, K., Schafe, G.E. & Le Doux, J.E. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406, 722–726 (2000).
  CAS PubMed Google Scholar
• Przybyslawski, J., Roullet, P. & Sara, S.J. Attenuation of emotional and nonemotional memories after their reactivation: role of beta adrenergic receptors. J. Neurosci. 19, 6623–6628 (1999).
  CAS PubMed PubMed Central Google Scholar
• Przybyslawski, J. & Sara, S.J. Reconsolidation of memory after its reactivation. Behav. Brain Res. 84, 241–246 (1997).
  CAS PubMed Google Scholar
• Debiec, J. & Ledoux, J.E. Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Neuroscience 129, 267–272 (2004).
  CAS PubMed Google Scholar
• Eisenberg, M. & Dudai, Y. Reconsolidation of fresh, remote, and extinguished fear memory in medaka: old fears don't die. Eur. J. Neurosci. 20, 3397–3403 (2004).
  PubMed Google Scholar
• Paulus, M.P., Feinstein, J.S., Castillo, G., Simmons, A.N. & Stein, M.B. Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing. Arch. Gen. Psychiatry 62, 282–288 (2005).
  CAS PubMed Google Scholar
• Dostrovsky, J.O. et al. Microstimulation-induced inhibition of neuronal firing in human globus pallidus. J. Neurophysiol. 84, 570–574 (2000).
  CAS PubMed Google Scholar