Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA (original) (raw)

Nature Neuroscience volume 10, pages 1513–1514 (2007)Cite this article

Abstract

Both increases and decreases in methyl CpG–binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

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Acknowledgements

We thank Q. Zhang for the experiments examining CtBP. This work was supported by grants from the US National Institutes of Health and the Rett Syndrome Research Foundation.

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Authors and Affiliations

  1. Vollum Institute, Oregon Health & Science University L-474, 3181 SW Sam Jackson Rd., Portland, 97239, Oregon, USA
    Matthew E Klein, Daniel T Lioy, Lin Ma, Soren Impey, Gail Mandel & Richard H Goodman

Authors

  1. Matthew E Klein
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  2. Daniel T Lioy
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  3. Lin Ma
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  4. Soren Impey
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  5. Gail Mandel
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  6. Richard H Goodman
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Contributions

M.E.K., D.T.L. and R.H.G. designed the experiments. M.E.K., D.T.L. and L.M. carried out the experiments. M.E.K., D.T.L., L.M., S.I., G.M. and R.H.G. wrote the paper.

Corresponding author

Correspondence toRichard H Goodman.

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Klein, M., Lioy, D., Ma, L. et al. Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA.Nat Neurosci 10, 1513–1514 (2007). https://doi.org/10.1038/nn2010

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